The 5th universal definition of MI invokes the concept of "regional ST-segment depression" due to supply-demand imbalance.🤦♂️
This concept is incorrect and misleading, because subendocardial ischemia DOESN'T localize to any region.
There are really just TWO possible patterns of acute myocardial ischemia on an ECG:
[#1] Subendocardial ischemia (diffuse STD).
[#2] Transmural ischemia (which often causes regional STE and regional ST depression due to reciprocal changes).
The concept of "regional ST-segment depression due to supply-demand mismatch" is misleadingly dangerous, because this is often *incorrectly* invoked to explain regional reciprocal STD. This causes clinicians to *miss* the true diagnosis of transmural infarction (e.g., posterior transmural ischemia causing anterior STD).
It would be safest to eliminate the myth of "regional ST-segment depression due to supply-demand mismatch" in order to force ECG readers to choose between the only two real ECG manifestations of ischemia: subendocardial ischemia or transmural ischemia.