Want to become a peer reviewer for the Academy's Ophthalmology journal at #aao2026? Aaki Shukla, MD, MSc (@AakiShuklaMD and Benjamin Xu, MD, PhD, highly experienced reviewers and authors for various journals, will lead this free interactive workshop. ow.ly/8x4K50ZIg57

A 70-year-old man presented with left periorbital pain. He had a history of frontal lobe meningioma resection 9 years prior. Examination revealed left proptosis, inferior globe displacement, and restricted upward motility. Computed tomography showed a mixed-density lesion in the superior left orbit, with a partial defect of the superior orbital wall. Magnetic resonance imaging demonstrated a cystic extraconal lesion, isointense on T1 (A), hyperintense on T2 (B), with peripheral enhancement (C) and inferior globe displacement. Intraoperatively, a large piece of bone wax (asterisk, D) and a cyst (red arrow) were observed. Histopathology showed surrounding chronic inflammation and fibrosis, without tumor recurrence. ow.ly/CJAm50ZIpRf #ophthalmology

New Ophthalmology Journal Podcast! @EdmundTsuiMD interviews a team of researchers from @nyugrossman: Galen Hu, @vjsriniv, and Nitish Mehta. The team discusses their case study which applied ultra-high resolution visible light optical coherence tomography towards acute and chronic lacquer cracks in a patient with pathologic myopia. Listen here: aao.org/education/audio/lacq… #ophthalmology #ophthalmologyjournal #podcast

A 43-year-old man presented with a 2-month history of progressive blurred vision in his left eye. Funduscopy showed diffuse choroidal thickening and a leopard-spotted retinal pigment epithelium (A). B-mode ultrasonography revealed flat, homogeneous, hypoechoic choroidal thickening with episcleral extension (B, outlined in red). Color Doppler imaging demonstrated prominent vascular flow perforating the sclera (C). Whole-body positron emission tomography–computed tomography showed no systemic involvement. Biopsy of the episcleral lesion confirmed primary uveal mucosa-associated lymphoid tissue lymphoma (D); immunohistochemistry demonstrated CD20/CD79a/CD5 positivity, with IGH gene rearrangement. Systemic rituximab and low-dose radiotherapy (24 Gy) achieved significant lesion regression and improved visual acuity at 6-month follow-up. aaojournal.org/article/S0161… #ophthalmology

An ex-30-week-old boy born at 1510 g was followed up for retinopathy of prematurity (ROP). Examination revealed morning glory disc anomaly of the left eye (OS) (B) and asymmetric ROP, with stage 3 OS (C) and minimal immature retina of the right eye (OD) (A). Given advancing postmenstrual age, fluorescein angiography was conducted, demonstrating late leakage at the ridge of OS (D) and no leakage in OD. Panretinal photocoagulation was performed in OS only, leading to resolution of disease. Morning glory disc anomaly has been associated with incomplete peripheral vascular development, which may have contributed to the asymmetric presentation of ROP. ow.ly/cIB850ZIXlX #ophthalmology

What are the most important papers published in Ophthalmology? Find out from our editors at “The Year in Literature” at #aao2026 in New Orleans! Attendees can claim 1 CME. Search SYM32 in the Mobile Meeting Guide for more info. We hope to see you there! aao.apprisor.org/apsSession.…

A 33-year-old man with a known history of gout presented with a 1-year history of a growing right medial canthus lesion. Examination revealed a 1.5-mm subepidermal nodule overlying the medial canthal tendon (A), initially suspected to be an epidermal inclusion cyst. Excision and histopathologic analysis confirmed a gouty tophus, demonstrating feathery clefts from dissolved urate crystals and multinucleated histiocytes (B and C, hematoxylin and eosin staining, 10× and 40×, respectively). The patient had never been on urate-lowering therapy. His most recent uric acid level was 6.6 mg/dL (reference range, 3.4–7.0 mg/dL). Periocular gouty tophi, although uncommon, should remain in the differential diagnosis of subepidermal periocular nodules, particularly in patients with a known history of gout. ow.ly/p74y50ZIpPJ #ophthalmology

A 67-year-old woman developed acute secondary angle closure shortly after high-dose adjuvant interferon alfa 2b therapy for acral melanoma, complicated by severe thrombocytopenia (57 × 109/L). Ultrasonography revealed spontaneous suprachoroidal hemorrhage in the right eye (A, yellow asterisk; B) and ciliochoroidal detachment in the fellow eye (A, blue triangle), causing anterior rotation of the ciliary body and angle closure. Severe thrombocytopenia, possible interferon-associated vascular injury, and underlying hypertension may have contributed to this hemorrhagic event. Complete resolution within 1 month was achieved with conservative management (C, D). This case highlights a rare but potentially sight-threatening ocular complication of interferon therapy. ow.ly/nQcO50ZIpNU #ophthalmology

Editorial: How Did We Get Here? Reframing Dry Eye Disease and Charting a Path Forward ow.ly/L2Bs50ZP6pq #ophthalmology

Editorial: What Does the US Food and Drug Administration Regulation of Portable Perimeters Mean? ow.ly/BeMl50ZP6p3 #ophthalmology #glaucoma

A 26-year-old woman with isolated microspherophakia and a posteriorly dislocated crystalline lens (A) was scheduled to undergo pars plana vitrectomy and lensectomy. On the day of surgery, she presented with acute, severe eye pain. Slit-lamp examination revealed anterior migration of the previously dislocated lens, resulting in pupillary block (B), corneal edema, a collapsed anterior chamber, and markedly elevated intraocular pressure. Anterior segment OCT demonstrated the spherical crystalline lens causing pupillary block, iris bombé, and angle closure (C). This case highlights the potential for a posteriorly dislocated microspherophakic lens to cause sight-threatening acute pupillary block. ow.ly/RaGN50ZAwlr #ophthalmology #glaucoma

The October issue of Ophthalmology is out now! Featuring articles on: ✅Ocular Inflammation as a Risk Factor for Anti-Adalimumab Antibodies in Patients with Autoimmune Diseases Treated with Adalimumab ✅Intravitreal Bevacizumab Improves Trabeculectomy Survival at 3 Years: Long-term Follow-up from The ‘Bevacizumab in Trabeculectomy Study’ ✅Semaglutide and Neovascular Age-Related Macular Degeneration Among Adults with Type 2 Diabetes: An OHDSI Network Study ✅Early Optic Nerve Head Swelling Rate is Associated with Worsening of Visual Outcomes in Nonarteritic Anterior Ischemic Optic Neuropathy And much more! aaojournal.org/issue/S0161-6… #ophthalmology

The September/October issue of Ophthalmology Glaucoma is out now! Featuring articles on: ✅Corneal Endothelial Keratoplasty Following Glaucoma Treatment: An American Academy of Ophthalmology IRIS® Registry (Intelligent Research in Sight) Analysis ✅The association between a pharmacy-based estimate of medication adherence and surgical and laser treatment in glaucoma patients ✅Ophthalmologist and Optometrist Co-management Model for Glaucoma: Outcomes from a Single Tertiary Care Health Center ✅Family Screening in Glaucoma: A Scoping Review And much more! ophthalmologyglaucoma.org/is… #ophthalmology #glaucoma

A 43-year-old man was referred for idiopathic central serous chorioretinopathy in his left eye with a visual acuity of 20/50. Five years earlier, he had undergone liver transplantation for hereditary transthyretin amyloidosis Val30Met mutation. (A) Color fundus photograph and (B) OCT showed subretinal fluid. (C) Fluorescein angiography disclosed a focal leakage point. Early-phase indocyanine green angiography (ICG) revealed concurrent intervortex anastomoses (not shown), followed by (D) late-phase ICG (30 min) demonstrating a characteristic bilateral “firework”-like pattern, with linear segments of ICG staining along the choroidal arteries, consistent with choroidal amyloid angiopathy. Adequate acquisition time (>12 min) is necessary to unmask this angiographic pattern, unsuspected on fundus exam, which correlates with systemic amyloid disease severity. ow.ly/Igcp50ZAwi3 #ophthalmology #retina

A 23-year-old man who presented with blurred vision after push-ups was found to have a white blood cell count of 120 000/mm3, hemoglobin level of 4.4 g/dL, and platelet count of 19 000/mm3. Bone marrow biopsy confirmed acute lymphoblastic leukemia, and brain/orbit magnetic resonance imaging showed no mass lesions. Vision was 20/30 right and 20/250 left. Fundus imaging (A, B) showed subinternal limiting membrane and intraretinal hemorrhages with white centers. OCT illustrated subinternal limiting membrane hemorrhage in the macula and posterior pole (C). His vision and examination improved with the administration of systemic pegaspargase/cytarabine/6-mercaptopurine/vincristine/rituximab/cyclophosphamide/methotrexate and observation over 4 months (D). White-centered multilayered hemorrhages represent a manifestation of leukemic retinopathy arising from anemia, thrombocytopenia, and hyperviscosity and warrant systemic evaluation. ophthalmologyretina.org/arti… #ophthalmology #retina

An 80-year-old woman presented with 4-mm relative left-sided proptosis over several years. Approximately 30 years previously, a pleomorphic adenoma of the left lacrimal gland had been excised via lateral orbitotomy with intraoperative frozen section. Computed tomography showed multiple discrete nodules involving the left orbital roof, lateral wall, and temporal fossa (arrows) with bony remodeling and focal defects of the frontal sinus and anterior cranial fossa (A–D). The multifocal distribution was attributed to seeding secondary to violation of the original tumor’s capsule. Given the risk of malignant transformation of the presumed recurrent pleomorphic adenoma, magnetic resonance imaging surveillance was recommended. ow.ly/Cjyn50ZAwb6 #ophthalmology

The September issue of Ophthalmology September is out now! Featuring articles on: ✅Vision-Related Patient-Reported Outcomes in Randomized Controlled Trials of Age-Related Macular Degeneration: A Systematic Review ✅Machine Learning Prediction of Strabismus With and Without Amblyopia from Fixation Eye Movements ✅Quantification of ocular gene therapy-related inflammation using the VRMACS grading system ✅Fusing Structural Phenotypes with Functional Data for Early Prediction of Primary Angle-Closure Glaucoma Progression And much more! ophthalmologyscience.org/iss… #ophthalmology

A 49-year-old man presented with a left upper eyelid mass that had rapidly enlarged over the past month. It originated as a pimple-like lesion that he had scratched, resulting in intermittent bleeding. Examination revealed a ∼2 × 2 cm, firm, reddish mass of vascular appearance and excoriations at its apex (white arrow). The mass was attached near the lash line at its base (A), causing mechanical ptosis (B). After excisional biopsy, histopathology (C, D) demonstrated polypoid lobulated growth of capillary-sized vessels (inset) with intervening myxoid connective tissue and occasional mitotic figures (black arrow). The diagnosis was an atypically large pyogenic granuloma, most likely originating from a hordeolum. aaojournal.org/article/S0161… #ophthalmology

A 24-year-old man complaining of nyctalopia had best-corrected visual acuity of 20/400 in the right eye (OD) and 20/40 in the left eye. Fundus showed disc pallor, arteriolar attenuation, midperipheral bone spicule pigments, predominantly nasally in both eyes (OU), with macular excavation OD (A). Fundus autofluorescence demonstrated punctate hypoautofluorescent lesions OU (B), with a sharply demarcated hypoautofluorescent foveal lesion OD. OCT showed outer retinal atrophy OU with a large choroidal excavation OD (C, D). Genetic testing revealed a homozygous pathogenic deletion in the CDHR1 gene (c.616del). CDHR1-associated retinopathy typically shows macular alteration and outer retinal loss. The excavation likely reflects a severe effect of the variant early in embryogenesis. ow.ly/lL4k50Zz13x #ophthalmology #retina

New Ophthalmology Journal Podcast! @EmSchehMD is joined by Dr. Clara C. Chan and @AndrewMihalache to discuss their report that showed individuals with Fuchs’ endothelial corneal dystrophy exhibited a higher burden of cardiometabolic disease than matched controls. Listen here: aao.org/education/audio/fuch… #ophthalmology #ophthalmologyjournal #podcast

A 33-year-old man presented with reduced vision and mild nyctalopia. Anterior segment examination was unremarkable, with no evidence of inflammation. Dilated fundus examination revealed a striking golden-yellow retinal sheen or tapetal reflex, which was most prominent in the temporal periphery (A and B). OCT demonstrated outer retinal degeneration with juxtafoveal cysts (C and D), and full-field electroretinogram was electronegative. Molecular testing identified a novel hemizygous RS1 variant (c.616T>A; p.W206R), supporting a diagnosis of X-linked retinoschisis. The Mizuo phenomenon could not be demonstrated after 2 hours of monocular patching. ow.ly/XzPu50Zz12h #ophthalmology #retina