Investigative Ophthalmology & Visual Science (IOVS) is an open access, peer-reviewed online journal of the Association for Research in Vision in Ophthalmology.
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New Editorial by IOVS editors Subhabrata Chakrabarti, Anthony Khawaja, Jeremy A. Guggenheim & Janey L. Wiggs updates the journal's guidelines bit.ly/4wpr4eE for ophthalmic genetic studies.
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Katarzyna Ognik et at. from the University of Life Sciences in Lublin describe clinical and population-specific insights into inherited retinal dystrophies from whole-exome sequencing of the Polish cohort.
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Christopher L. Passaglia et al. from the University of South Florida investigate the role of norepinephrine (NE) in circadian rhythms of rat IOP and conventional outflow facility.
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Yalin Zheng, Sarah E. Coupland et al. from the University of Liverpool describe deep learning classification of uveal melanoma and metastatic carcinoma on cytology specimens.
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Rajeev H. Muni et al. from St. Michael's Hospital investigate the mechanical forces exerted by perfluorocarbon liquid (PFCL) during pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD) using a computational model of retinal dynamics.
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Ian Pitha et al. from The Johns Hopkins University School of Medicine use sparse cell labeling to reveal morphologic diversity among mouse scleral fibroblasts.
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Wolf Harmening et al. from the University of Bonn investigate differences in preferred retinal loci of fixation in binocular and monocular vision.
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Jin Yuan et al. from Beijing Tongren Eye Center find that T cell–derived IFN-γ activates ferroptosis in lacrimal luminal ductal cells via JAK-STAT signaling in Sjögren's disease-related dry eye.
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Review article by Ruihua Wei, Yankai Wei et al. from Tianjin Medical University Eye Hospital discusses the role of S100A8/A9 in autoimmune eye diseases, from pathogenesis to targeted therapy.
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Alexandra Zamitalo-Pomares & Christopher L. Passaglia from the University of South Florida investigate adrenergic receptor mechanisms underlying circadian intraocular pressure (IOP) regulation in rats.
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Edoardo Midena et al. from the University of Padova investigate the behavior of the external limiting membrane and ellipsoid zone in diabetic macular edema using artificial intelligence (AI)-based optical coherence tomography (OCT) quantification.
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Qingfeng Liang et al. from Beijing Tongren Hospital find that mycovirus infection attenuates A flavus pathogenicity & modulates host responses in fungal keratitis, suggesting a role for viral carriage in the clinical heterogeneity of disease severity.
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Kanmin Xue et al. from the University of Oxford find that apolipoprotein E2/2 (APOE2/2) genotype is associated with reduced choroidal thickness.
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Adrian V. Cioanca et al. from The Australian National University use a multiomics approach to reveal novel miRNA–mRNA–protein expression profiles in the aged female retina.
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Silvia Montaner et al. from the University of Maryland find that angiopoietin-like 4 induces upregulation of VEGF and sVCAM1 through JNK/c-Jun and JAK2/STAT5 signaling pathways.
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Amani A. Fawzi et al. from Cole Eye Institute find that outer retinal volume on macular OCT predicts two-year diabetic retinopathy progression.
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Feng Zhang et al. from Zhongshan Ophthalmic Center use long-read single-cell RNA sequencing to reveal dynamic Iisoform changes during corneal epithelial wound healing in cynomolgus monkeys.
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New article in the Nystagmus issue bit.ly/3T5ko7A by Fatema Ghasia et al. from Cole Eye Institute uses deep brain stimulation to provide a Window Into the Neural Mechanisms of Latent Nystagmus.
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Leopold Schmetterer et al. from the Singapore Eye Research Institute develop and externally validate an explainable artificial intelligence model integrating OCT and OCTA for mild primary open-angle glaucoma.
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Biao Yan et al. from Shanghai Jiao Tong University School of Medicine use integrated multi-tissue omics to identify acylcarnitine accumulation as shared metabolic marker of diabetic microangiopathy with cross-organ validation.
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Toco Y. P. Chui et al. from the New York Eye and Ear Infirmary of Mount Sinai characterize leukocyte crawling dynamics in the retinal vasculature of healthy volunteers & 3 patients with systemic diseases using adaptive optics scanning light ophthalmoscopy.
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