Aging Science News
@AgingBiology

Latest news in the biology and genetics of aging, covering longevity science, rejuvenation technologies and life-extension research. Tweets by @jpsenescence

senescence.info/
Joined November 2013
125 Photos and videos
New description of the Human Ageing Genomic Resources (HAGR) Since its inception 20 years ago, HAGR has become the leading online platform in ageing research. A brief thread on HAGR's databases 🧵 academic.oup.com/nar/article…

Human Ageing Genomic Resources: updates on key databases in ageing research

Abstract. Ageing is a complex and multifactorial process. For two decades, the Human Ageing Genomic Resources (HAGR) have aided researchers in the study of

academic.oup.com
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Extreme longevity revealed by 24-year genetic mark–recapture challenges conservation of endangered sea cucumbers cell.com/iscience/fulltext/S…

Extreme longevity revealed by 24-year genetic mark–recapture challenges conservation of endangered...

Marine organism; Nature conservation; Zoology

cell.com
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Young organs may not be a fountain of youth for recipients technologyreview.com/2026/09…

Young organs may not be a fountain of youth for recipients

New studies pour cold water on a prominent rejuvenation idea.

technologyreview.com
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Loss of killifish cGAS attenuates age-related signatures but does not affect organismal life span link.springer.com/article/10…

Loss of killifish cGAS attenuates age-related signatures but does not affect organismal life span

EMBO Reports - The cGAS/STING pathway is a central innate immune signaling pathway responsive to cytosolic DNA. Chronic activation of this pathway promotes numerous age-related pathologies, but its...

link.springer.com
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Biological aging clocks as biomarkers of human aging: Biological basis, methodological design, and epidemiological implications sciencedirect.com/science/ar…
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Senescence-directed nanotherapy ameliorates fibrosis and overcomes immune exclusion in cancer science.org/doi/10.1126/scie…

Senescence-directed nanotherapy ameliorates fibrosis and overcomes immune exclusion in cancer

Fibrotic remodeling of tissues and tumors establishes immunosuppressive microenvironments that drive organ dysfunction and, in cancer, limit response to immunotherapy. Senescent-like cells are...

science.org
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Mitochondrial Fusion and Fission in Age-Related Cardio-Cerebral Diseases: Mechanisms and Interventions onlinelibrary.wiley.com/doi/…

Mitochondrial Fusion and Fission in Age‐Related Cardio‐Cerebral Diseases: Mechanisms and Interven...

Mitochondrial fission-fusion imbalance contributes to age-related cardio-cerebral diseases like Alzheimer's disease, Parkinson's disease, Cerebral Infarction, Arteriosclerosis, Myocardial Infarctio...

onlinelibrary.wiley.com
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Nanotherapy against senescence science.org/doi/10.1126/scie…

Nanotherapy against senescence

Targeting senescence decreases fibrosis and boosts the response of cancer cells to immunotherapy

science.org
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The Role of EVs in the Aging Hematopoietic System onlinelibrary.wiley.com/doi/…

The Role of EVs in the Aging Hematopoietic System

Extracellular vesicles from aged bone marrow carry pro-inflammatory cargo that drives blood stem cell decline, while youthful vesicles restore or maintain stem cell function. Circulating vesicles...

onlinelibrary.wiley.com
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Mitochondrial Transplantation Rejuvenates Aging Heart by Restoring Mitophagy Flux via the HIF-3α-BNIP3 Axis onlinelibrary.wiley.com/doi/…

Mitochondrial Transplantation Rejuvenates Aging Heart by Restoring Mitophagy Flux via the HIF‐3α‐...

Aging heart shows mitophagy flux congestion and mitochondrial dysfunction. Aberrant activation of the HIF-3α-BNIP3 axis induces mitophagy flux congestion in the aging heart. Mitochondrial transplan...

onlinelibrary.wiley.com
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Transplanted hearts assimilate the recipient’s biological age biorxiv.org/content/10.64898…

Transplanted hearts assimilate the recipient’s biological age

Background Despite the growing demand for transplantation, a shortage of donor organs persists, limiting access to this lifesaving procedure. To meet the increasing demand, organs are frequently...

biorxiv.org
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Extracellular Vesicles From Senescent Cancer Cells Are Necessary and Sufficient to Drive Paracrine Senescence onlinelibrary.wiley.com/doi/…

Extracellular Vesicles From Senescent Cancer Cells Are Necessary and Sufficient to Drive Paracrine...

Senescent cancer cells exhibit a secretory phenotype, known as SASP, capable of inducing paracrine senescence. However, the main factors within the SASP triggering this process are unknown. Here, we...

onlinelibrary.wiley.com
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Twisting the End Game: How Telomere Chromatin Modifications Shape Telomere Maintenance onlinelibrary.wiley.com/doi/…

Twisting the End Game: How Telomere Chromatin Modifications Shape Telomere Maintenance

Chromatin modifications on telomeres are linked to the mode of telomere DNA replication. A coupled feedforward loop model is proposed based on these to lock the ALT cancer cells in this alternative...

onlinelibrary.wiley.com
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NAD+ augmentation in brain aging: hype, hope, or emerging reality? cell.com/trends/endocrinolog…

NAD+ augmentation in brain aging: hype, hope, or emerging reality?

Restoring NAD+ to physiological levels shows promise for countering brain aging and neurodegeneration, backed by preclinical and growing clinical evidence. Key challenges remain: measurement validi...

cell.com
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Cysteine excess triggers a mitochondrial iron-dependent cell death nature.com/articles/s42255-0…

Cysteine excess triggers a mitochondrial iron-dependent cell death

Nature Metabolism - Using a genome-wide CRISPR screen, the authors demonstrate that excess cysteine drives mitochondrial iron accumulation and iron–sulfur cluster failure, triggering a...

nature.com
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All the ways a cell can die — and why the variety matters nature.com/articles/d41586-0…

All the ways a cell can die — and why the variety matters

Nature - Scientists are poking holes in established ideas about how cells live and die, and are harnessing these discoveries to fight diseases from cancer to autoimmune conditions.

nature.com
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Cytotoxic CD4+ T cells induce age-associated myelopoiesis through CCL5–CCR5 signaling nature.com/articles/s43587-0…

Cytotoxic CD4+ T cells induce age-associated myelopoiesis through CCL5–CCR5 signaling

Nature Aging - Gabandé-Rodríguez, Soto-Heredero and colleagues identify an accumulation of cytotoxic CD4+ T cells producing CCL5 in the bone marrow during aging, linked to age-associated...

nature.com
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Multiparametric in vivo mapping reveals tissue-specific mitochondrial aging trajectories biorxiv.org/content/10.64898…

Multiparametric in vivo mapping reveals tissue-specific mitochondrial aging trajectories

Mitochondrial dysfunction is a hallmark of aging, yet how mitochondrial states are remodeled across tissues and subcellular compartments in vivo remains elusive. Progress has been limited, in part,...

biorxiv.org
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The chemical fingerprint of cellular senescence nature.com/articles/s43587-0…

The chemical fingerprint of cellular senescence

Nature Aging - Senescence has traditionally been studied largely on the basis of changes in gene expression, but senescent cells also undergo profound biochemical remodeling. Zhang and colleagues...

nature.com
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Meal timing and eating window with all-cause and cardiovascular mortality and life expectancy: population-based cohort study nature.com/articles/s41430-0…

Meal timing and eating window with all-cause and cardiovascular mortality and life expectancy:...

European Journal of Clinical Nutrition - Meal timing and eating window with all-cause and cardiovascular mortality and life expectancy: population-based cohort study

nature.com
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European Innovation Council support for healthy aging biotechnology nature.com/articles/s43587-0…

European Innovation Council support for healthy aging biotechnology

Nature Aging - European Innovation Council support for healthy aging biotechnology

nature.com
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