Our new paper is out @Nature We report that fibrin drives toxic inflammation, impaired viral clearance & neuropathology in #SARSCoV2 infection treated by #fibrin antibody #LongCovid #Coagulation #Immunotherapy #fibrinogen #COVID19 nature.com/articles/s41586-0…

Aug 28, 2024 · 4:12 PM UTC

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Study led by @JaeKyuRyu @yan_zhaoqi Mauricio Montano, Elif Sozmen, Karuna Dixit, Rahul Suryawanshi In collaboration w/ the labs of Warner Greene @TheOttLab @DoctorBou @kristyredhorse @xanderpico @KroganLab Mark Ellisman @GladstoneInst @UCSF @UCLA @UCSanDiego @Stanford @QBI_UCSF @SDSC_UCSD @UCLAQCBio @MicrobioUcla nature.com/articles/s41586-0…
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Our study shows that coagulation serves as an apical driver of infection-induced inflammation and neuropathology, and fibrin-targeting immunotherapy may represent a therapeutic intervention for patients with Long COVID. Grateful to our funders @NIH @NIH_NINDS @NIHAging @NIAIDNews @RoddenberryFdn @BrightFocus @mssociety @NSF @HHMINEWS nature.com/articles/s41586-0…
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Press release “Discovery of How Blood Clots Harm Brain and Body in COVID-19 Points to New Therapy’ by Kelly Quigley @GladstoneInst gladstone.org/news/discovery…

Discovery of How Blood Clots Harm Brain and Body in COVID-19 Points to New Therapy | Gladstone...

A new study in Nature overturns the prevailing theory that blood clotting is merely a consequence of inflammation in COVID-19.

gladstone.org
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Sort replies: Relevant Recent Liked
Replying to @AkassoglouLab @Nature
Congratulations on a great study.
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Thank you very much for your kind words Dr. Costello. @globalhlthtwit
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Replying to @AkassoglouLab @Nature
Beautiful 💫 translational and impactful! Congratulations @AkassoglouLab and team!
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Thank you Fanny! @FannyElahi
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Replying to @AkassoglouLab @Nature
Really beautiful work. Many congratulations!
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Thank you so much Nicola! @nikmutch
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Replying to @AkassoglouLab @Nature
Congratulations on a well-done, truly innovative and incredibly important study.
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Thank you for your kind words @knityarn!
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Replying to @AkassoglouLab @Nature
Congrats Katerina & team!!
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Thank you so much Marta! @mcortescanteli
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Replying to @AkassoglouLab @Nature
Amazing work Katerina, congratulations to you and the team!
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Thank you very much Niccolo! @NiccoloTerrando
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Replying to @AkassoglouLab @Nature
Congratulations, @AkassoglouLab and team!
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Thank you so much Sonali!
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Replying to @AkassoglouLab @AxL_Montagne @Nature
Amazing work congratulations 👏
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Thank you @caromenard666!
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Replying to @AkassoglouLab @BeaGPerezNievas @Nature
Congrats @AkassoglouLab 👏🏻👏🏻👏🏻👏🏻
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Thank you Maria @MariAngelesMoro!
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Replying to @AkassoglouLab @Nature
Important work - congrats to you and your team!
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Thank you very much @JM_Castell!
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Replying to @AkassoglouLab
Congrats on such a beautiful work!👏👏👏
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Thank you Nannan @NannanLu3!
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Replying to @AkassoglouLab @Nature
Congrats Katerina and team 🤩
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Thank you Axel @AxL_Montagne!
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Replying to @AkassoglouLab @Nature
congratulations! Remarkable paper.
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Thank you very much Dr. Platanias @LeonidasPlatan1!
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Replying to @AkassoglouLab @Nature
What is the mechanism that drives the positive feedback loop that causes this to persist post infection? Is it possible that there are simply tissue bound viral reservoirs?
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Replying to @AkassoglouLab @Nature
Your publication is a landmark for Long COVID and Postviral syndromes. Your findings need more attention. The key therapy seems to be HELP apheresis.
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Replying to @AkassoglouLab @Nature
Thanks for your efforts. Layman's recap for anybody interested: gladstone.org/news/discovery…
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Replying to @AkassoglouLab @Nature
Amazing work. As a person w/ Long Covid I've been following the science and we're learning some incredible things. Hopefully it eventually translates into some therapeutics!
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Replying to @AkassoglouLab @Nature
I thought this AI summary from Eric Topol's page was interesting: x.com/BensenHsu/status/18288…
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Replying to @AkassoglouLab @Nature
And what's your take on the use of a fibrinogen regulator like Lumbrokinase?
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Replying to @AkassoglouLab @Nature
Beautiful research. Congrats to your team! I'd like to ask about the stage of the mAb clinical trial. My research unit is committed to developing trials in longCOVID; we were an active center in the 2 main ones in Europe. Contact me via DM for any comments. Thanks!
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