accelerating science for a healthier world
Seattle, WA
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What if the next breakthrough for human health, climate resilience, or clean energy isn’t waiting to be found in nature, but is waiting to be designed?
Today, we’re launching AI BioDesign, a bold endeavor to explore the uncharted design space of life.
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SON is our cell line of the week! SON and its associated plasmid illuminates nuclear speckles, a real science word for proteins in the nucleus involved in gene expression.
Thanks to our partners at @Coriell_Science and @addgene for helping us make our cell lines accessible.
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"What else is possible, and how can we test it?"
David Baker on AI BioDesign — the new $95M Allen Institute, UW & Fred Hutch effort to design proteins nature never made, with all data shared freely.
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Could this new brain map help fight diseases like ALS and dementia?
Our scientists and collaborators have created the most detailed map yet of the mouse motor cortex, identifying 16 distinct subregions with their own patterns of connections.
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Using 547 experiments and the Allen Institute’s foundational connectivity atlas, the map shows how motor cortex regions connect with areas involved in movement, planning, and decision-making. bit.ly/3V6sm0R
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This precision map gives researchers a shared reference for studying the motor cortex, and could help advance understanding of diseases such as ALS and frontotemporal dementia. The study was published today in Cell: bit.ly/4rpKaA0
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Nature has been inventing proteins for billions of years, but it hasn't tried everything. David Baker co-leads AI BioDesign, our new accelerator in collaboration with @uwmedicine and @fredhutch, to design molecules that could break down plastic and target cancer with precision.
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Read Jorge Garay's coverage of AI BioDesign for @WIRED: bit.ly/4drEwrm
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A big thank you to @biolamina for sponsoring our Stem Cell and Developmental Biology Early Career Symposium! Support like this is what makes it possible to bring together the next generation of researchers to share their science, build connections, and launch what comes next.
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1 in 3 people lives with a neurological or brain condition such as Alzheimers, depression, or addiction. We need to speed up our understanding of how the human brain works to accelerate progress toward new treatments.
We launched the Brain Health Accelerator to do just that.
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In partnership with the Bezos family, Amazon Web services, Everything.ALS and a global network of collaborators, we aim to understand what drives brain disease starting with Alzheimer's, Parkinson's, ALS, Huntington's, and Lewy Body Dementia.
#WorldAlzheimersDay #EndAlz
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Our #CellLineOfTheWeek is mitochondrial transcription factor A or TFAM! 🧫✨
This cell line and its associated plasmid illuminates mitochondrial nucleoids - clusters of DNA within the mitochondria.
📦 Distributed by @Coriell_Science & @Addgene
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Deep in the brain’s “blue place,” our scientists found something surprising: a tiny brain region once thought to broadcast one signal actually sends targeted messages through distinct routes, including via the longest neuron ever measured in a mouse.
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Read our story: bit.ly/3UT5ge5
Explore the Nature study: go.nature.com/4AeoISx
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allen institute retweeted
Science moves faster when knowledge is shared openly.
From the time I entered graduate school, I became fascinated by what open sharing of data could do in fields as disparate as physics, art, and coding. Total strangers helping each other go further.
Sharing knowledge openly is part of the ethos of the @AllenInstitute. Every year, millions of people use our open data and tools to power their research, to learn, and even to make art. We take on foundational projects that are needed and are too big for any single lab to tackle, and build them from day one to be shared. We need to share and work together to accelerate science for a healthier world.
This #OpenScienceWeek, join me in celebrating the scientists and organizations everywhere who share their data, tools, and knowledge to accelerate discovery.
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“That’s a big proof of concept, saying it’s possible to create this kind of human-dominated cortex in a mouse.” Executive Vice President and Director of Brain Science, @HongkuiZeng, weighs in on a new study by researchers at Stanford.
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