ODIA SCIENTIST AT THE FRONTIER OF #ALZHEIMER’S RESEARCH Dr. Satyabrata Kar — From Utkal University to the University of Alberta Dr. Satyabrata Kar, now a professor and neuroscientist at the University of #Alberta, is leading research that could open a new direction in the fight against Alzheimer’s disease. His team's latest study, published in the peer-reviewed journal Alzheimer’s & #Dementia, found that tiny biodegradable particles called PLGA nanoparticles reduced Alzheimer’s-related disease changes and improved cognitive and memory performance in mice. What makes the finding particularly interesting is that the #nanoparticles were not carrying another drug. The PLGA particles themselves appeared to have therapeutic effects. The research found reductions in the production and accumulation of beta-amyloid, a protein associated with Alzheimer’s plaques, along with improvements in several markers of brain health. The study suggests that PLGA may influence multiple disease-related pathways rather than targeting just one. And this achievement builds on years of work. Dr. Kar began investigating PLGA nanoparticles for Alzheimer’s around 2020, following earlier research showing their potential to protect neurons and interfere with protein aggregation. Why this is significant Dr. Kar has spent around three decades researching Alzheimer’s disease, according to the University of Alberta. He is now working with collaborators on the next major challenge: finding ways for these nanoparticles to cross the brain's protective blood-brain barrier and remain effective for longer periods. The important caveat is that this is still preclinical research in mice—not a proven treatment for people. Further testing, replication and development of a practical delivery method are needed before any human treatment could result. But for #Odisha, there is a particularly inspiring dimension: an academic journey connected to Utkal University has led to internationally recognized neuroscience research at one of Canada's major universities. Dr. Kar is also listed by the Canadian Academy of Health Sciences, which notes that his research has produced more than 115 peer-reviewed publications.