This account is no longer active. Please see our new department page @mgbpathology 🔬
Boston, MA
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We are officially transitioning to our joint department account @mgbpathology. The BWH-specific page will still exist for reference, but please see our new page for updates and interactions! 🙂
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If you missed our first open house, join us on September 12 at 7 pm US Eastern to learn about our @MGBpathology residency program. Los of info and awesome people to meet @MGHPathology here is the link to register partners.zoom.us/meeting/reg…
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Applicants to #pathmatch2025 : Join our first virtual open house session on Aug 19, 7 pm US Eastern!
Join our dept leaders, program directors and trainees for a friendly chat about the Mass General Brigham residency program @MGHPathology
Registration: partners.zoom.us/meeting/reg…
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We are heartbroken. Together we share our sorrow with the pathology and sarcoma communities, and with all who deeply admired and were inspired by Dr. Fletcher. In Memoriam: brighamandwomens.org/patholo…
#CDMF #Pathology #Pathologists #BSTPath #PathTwitter #PathX #Sarcoma
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Happy (slightly late) PA Day to all the amazing Pathologists’ Assistants out there from the BWH PA team! 🥼🩺
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Please join us on August 24th or September 21st for a virtual open house to learn more about the MGB Pathology Residency program and meet program leadership and residents. @MGHPathology
To register visit: education.mgbpathology.org/a…
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This is a case of metastatic high grade endometrial carcinoma to the ovary. The mass is solid to cystic, with areas of hemorrhage and necrosis.
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Welcome back to gross case of the week! This week we have a large mass received in the grossing room. Can you name the organ and pathology seen here?
#BWHGrossCOTW #PathAssist
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@BWHPath and @MGHPathology welcome 22 new residents to the Mass General Brigham Pathology Residency Program. We are thrilled that you will be joining us! Welcome to Boston.
Congratulations to everyone who matched in pathology today! 🍾🎉 #PathMatch2023
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This is an autopsy case of metastatic osteosarcoma. The mass is present as a tumor thrombus in the pulmonary artery. There is resulting surrounding parenchymal hemorrhage which also lead to blood clot within the bronchus.
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Welcome to the Gross Case of the Week! This week we have an autopsy case with interesting findings. #BWHgrossCOTW
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This is a case of papillary fibroelastoma of the heart! This lesion has a frond-like appearance that is like that of a sea anemone. This one has been floated in saline for the photograph to display how delicate the tissue strands can be.
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It is time for the Gross Case of the Week! This is a very distinct lesion. Can you name what is pictured here? #BWHgrossCOTW #PathAssist
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Happy Valentines Day from the BWH Pathology Twitter! Heart shaped lymph node courtesy of @pathnoob.
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This is total thyroidectomy with attached trachea for invasive papillary thyroid carcinoma. The mass has invaded through the trachea and encompasses most of the remaining right lobe of the thyroid.
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It is time for the gross case of the week! Here we have an extreme presentation. Can you name the resection and pathology demonstrated here? #GrossCOTW #PathAssist
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This is an example of a renal oncocytoma! These are very distinctive benign, well-circumscribed masses that often have a mahogany brown coloration. This example displays the mass pushing into the overlying soft tissue.
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We are back again with a Gross Case of the Week! This one is a very distinctive lesion. Can you name the resection and mass pictured here? #BWHgrossCOTW #PathAssist
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The pigmentation and extent of the tumor is best seen on a backlit section. The mass extends into the vitreous humor to abut the lens.
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This is a case of choroidal melanoma of the eye. The mass encompassed 270 degrees of the inner surface, detaching the retina and displaying perivascular invasion into the sclera.
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Hello and welcome to the Gross Case of the Week – Neuro Winter Edition! This week we have a rare surgical case. Can you guess what is pictured here? #GrossCOTW #NeuroWinter #PathAssist
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The third adrenal mass is a neuroblastoma! These can be ovoid to multilobulated and heterogenous in appearance with areas of hemorrhage. These have the worst prognosis of the three, with high risk cases having a 50% survival rate at 5 years.
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The second adrenal mass is a ganglioneuroblastoma! These are homogenous, chalky white ovoid masses and may have areas of cystic degeneration. These have a generally good prognosis and can even mature into ganglioneuromas.
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The first adrenal mass pictured is a ganglioneuroma! These are well circumscribed gray-white to tan-yellow masses that have a whorled appearance. These are benign and have the best prognosis of our trio of lesions.
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Hello and welcome to the Gross Case of the Week – Neuro Winter Edition! This week we have a trio of neuro cases that appear similar at first glance. #GrossCOTW #NeuroWinter
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H&Es show a cellular tumor with elongated nuclei, vacuolar chromatin, abundant cytoplasm, and mitoses. ALK, CD163, CD68, and Factor XIII were positive; S100 was patchy. Glial/neuronal markers were negative and INI1 and BRG1 were retained. What genetic alteration is present?
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An infant presented w/an intra-axial frontal lobe lesion. A craniotomy for total resection was performed, and H&E of the brain lesion showed the following. What is your differential diagnosis? What stains would you get? #BWHPathCotW #BWHNeuroPathWinter
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This is a case of a brain with Pick’s Disease or Frontotemporal Dementia (FTD). There is markedly severe atrophy of the frontal lobe; usually asymmetric. Although not pictured here, the anterior third of the temporal lobs is also characteristically atrophic.
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Hello and welcome to the Gross Case of the Week – Neuro Winter Edition! This week we have another case from autopsy. Can you guess what is pictured here? #GrossCOTW #NeuroWinter
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This is a special case honoring all the participating patients of the First in Human study at BWH testing a novel genetically engineered oncolytic herpes simplex virus as a GBM viral immunotherapy. Below is an anti-HSV IHC showing the oHSV in abundant tumor necrosis.
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Molecular analysis shows an unmethylated MGMT promoter, TERT promoter C228T mutation, EGFR amplification, 7+/10- chromosome copy # changes, and is IDH1/2 wild-type. These results along with the histological findings are consistent with a diagnosis of glioblastoma.
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A pt presents w/an intracranial enhancing non-expansile mass in the parietal lobe and extending into the ipsilateral temporal lobe. Biopsies taken during a craniotomy show the following. What is your DDx? What additional studies would you do? #BWHPathCotW #BWHNeuroPathWinter
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This is a case of a brain with Parkinson’s Disease treated with deep brain stimulation (DBS) electrodes. The electrodes are inserted through the cerebral cortex, traverse through the internal capsule, and go medial to the subthalamic nucleus.
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Hello and welcome to the Gross Case of the Week – Neuro Winter Edition! This week we have a case from autopsy. Can you guess what is pictured here? #GrossCOTW #NeuroWinter
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On sectioning, a circumscribed yellow necrotic mass was seen in the right frontal lobe/insula spanning from the cortical surface to the basal ganglia. The lesion was diffuse and non expansile, and therefore, did not impact the size of the lateral ventricles.
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This is a case of Glioblastoma. The patient had multiple prior craniotomies for treatment, resulting in stitching and scarring of the dura, and various defects in the superficial lateral and anterior aspects of the frontal lobe.
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Hello and welcome to the Gross Case of the Week – Neuro Winter Edition! This week we have a case with lesion from autopsy. Can you guess the mass pictured here? #GrossCOTW #NeuroWinter
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Case contributed by: Dr. Andres Santos (@SantosMDPHD), and Dr. David M. Meredith (@NeuropathDM). @BWHNeuropath
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H&E stains show bland spindled cells arranged in a lamellar fashion around nerve fascicles and intraneural vasculature (aka pseudoonion bulbs). Cells stain with Claudin-1 and EMA and are S100 negative. These findings are consistent with a dx of an intraneural perineurioma.
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A pt w/a history of various carpal tunnel surgeries, presented w/wrist pain and nerve conduction studies showing severe median neuropathy. Pt underwent a nerve allograft and the resected nerve showed the following. What stains would you order? #BWHPathCotW #BWHNeuroPathWinter
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When looking at the radiographic correlation, the area of meningioma is growing off the dura and perfectly matches the shape and dimensions of what is seen at the grossing bench.
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This is a case of a meningioma! Meningiomas are rounded, well circumscribed masses connected to the dura, which was received still attached in this case.
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Hello and welcome to the Gross Case of the Week – Neuro Winter Edition! This week we have a case from the grossing bench. Can you guess what is pictured here? #GrossCOTW #NeuroWinter #PathAssist
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Molecular analyses revealed a MAP2K1 (Q56P) mutation. These histologic features along with the MAP2K1 variant are consistent with the dx of Multinodular and Vacuolating Neuronal Tumor.
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H&Es shows monomorphic neuron-like cells arranged in discrete loosely formed hypomyelinated nodules with fibrillar and vacuolated matrix. Neuron-like cells show cytoplasmic pericellular vacuolization. What mutations do you predict will be present in this lesion?
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A patient presented w/an ill-defined FLAIR hyperintensity/T1 hypointensity in the temporal lobe on MRI and new onset partial seizures. The lesion was resected through a craniotomy. What is your differential dx? #BWHPathCotW #BWHNeuroPathWinter #PathTwitter #Neuropathology
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This is a case of staining from methylene blue (MB) seen at autopsy. In this case the patient received MB in the perimortem period as a last resort to revert severe hypotension refractory to vasopressors and fluid resuscitation.
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Hello and welcome to the Gross Case of the Week – Neuro Winter Edition! This week we have a case from autopsy. Can you guess what is pictured here? #GrossCOTW #NeuroWinter
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