Perplexed sceptic & genetic epidemiologist @mrc_ieu @MRC_BSU @BristolUniPsych. Tutor @LSHTM & @StEdmundsCam.
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Benji Woolf retweeted
New publication "What phases of the drug development framework can epidemiological studies emulate?" at Am J Epi led by me (!), with contributions from @ja_labrecque_, @BarWoolf, Emily, David R, and Sofia: academic.oup.com/aje/advance…
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Benji Woolf retweeted
New pre-print "Mendelian randomization in a multi-ancestry world: reflections and practical advice" led by @amymariemason - arxiv.org/abs/2510.17554
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Benji Woolf retweeted
Really important work (and delighted to help) using pulmonary hypertension as a disease exemplar. Applicable across all rare disease I expect.
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Benji Woolf retweeted
New manuscript led by @BarWoolf "A cautionary note on the naive use of general-population biobanks to study pulmonary arterial hypertension" is now published at Euro Respiratory Journal @ERSpublications: pubmed.ncbi.nlm.nih.gov/4096…. Summary follows:
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One of my students @StEdmundsCam has a really remarkable story of overcoming adversity to study @Cambridge_Uni. Sadly his scholarship can't fund the rest of his degree so he is trying crowdfunding. Any help would be really appreciated, thank you very much! gofundme.com/f/from-poverty-…
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Benji Woolf retweeted
New pre-print online: "Context-stratified Mendelian randomization: exploiting regional exposure variation to explore causal effect heterogeneity and non-linearity", arxiv.org/abs/2507.11088. We propose an alternative approach to assess non-linearity in Mendelian randomization.
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Benji Woolf retweeted
Forgot to add the link to the manuscript: academic.oup.com/ajeadvances….
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Benji Woolf retweeted
New paper published at AJE Advances: "The role of estimation in Mendelian randomization: should Mendelian randomization investigations provide estimates?" led by @BarWoolf and myself. Brief thread:
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Posting a tad late, but @jamesyrmsk and @dpsg108 and I have a new research letter in @intjepidemiol where we use negative controls to illustrate why drug use phenotypes should not be used as exposures in MR studies academic.oup.com/ije/article…
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Benji Woolf retweeted
🚨 New preprint awaiting feedback! 🚨 led by the lovely and talented @martaalcalde18 looking at the relationship between PDE5 inhibition and Alzheimer's disease using #mendelianrandomization (spolier: we found nada) medrxiv.org/content/10.1101/…
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And the accepted m/s is now out in the AJE! academic.oup.com/aje/advance… Thank you to @htcronje @dpsg108 @stevesphd @LoukasZagkos @LarssonSC Summary can be found
Had a lot of fun presenting our work (accepted this week at the AJE) on exposure miss-identification in MR, and how it results in directionally incorrect conclusions for studies of caffeine consumption at #mrconf24.
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Had a lot of fun presenting our work (accepted this week at the AJE) on exposure miss-identification in MR, and how it results in directionally incorrect conclusions for studies of caffeine consumption at #mrconf24.
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piped.video/watch?v=-8Gy0s3m… really enjoyed watching this seminar by @HarvardEpi on measurement error. Lots of food for thought.
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Our new study erj.ersjournals.com/content/… with James Perry, Charles Hong @mark_toshner, @stevesphd, @dpsg108, Martin Wilkins, and Chris Rhodes failed to find evidence supporting the use of IL6R inhibitors on pulmonary arterial hypertension.
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Benji Woolf retweeted
New Mendelian Randomization from @LoukasZagkos @htcronje @BarWoolf @stevesphd @Yuan_AS @LarssonSC @jotzou @dpsg108 et al.: Long-term increases in circulating #caffeine may reduce bodyweight and the risk of osteoarthrosis and osteoarthritis. shorturl.at/blySV
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Benji Woolf retweeted
**Flash Talks Event** Benjamin Woolf @BarWoolf shares his research "Comparison of caffeine consumption behavior with plasma caffeine levels as exposure measures in drug-target Mendelian randomization studies" Vote for your favourite talk: meg-uk.org/flash-talks-2024
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Benji Woolf retweeted
New paper: "A frequentist test of proportional colocalization after selecting relevant genetic variants": arxiv.org/abs/2402.12171 led by Ash Patel. We introduce a new test for colocalization in a frequentist paradigm. Thread follows!
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Really nice review by @htcronje and @stevesphd on the importance of sensible variant selection in MR
Our review "Incorporating biological and clinical insights into variant choice for Mendelian randomisation: examples and principles" written together with @htcronje and published at @eGastro_BMJ is now available at egastroenterology.bmj.com/co…. Brief thread:
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Benji Woolf retweeted
New study supports the potential for PDE5 inhibition to increase the number of children fathered by male patients, but finds no evidence of such an effect in female patients @BarWoolf #ChristmasBMJ
bmj.com/content/383/bmj-2023…
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Benji Woolf retweeted
Thanks to Benji (@BarWoolf) and Dipender (@dpsg108) for leading this work, and for Skanda, Toinét (@htcronje), James (@jamesyrmsk), and the BMJ editors for their willingness to engage with both the science and the humour of the article. /END
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