Four bispecific IgGs:
- Teclistamab (BCMA x CD3): recruits T cells
- Faricimab (VEGF-A x Ang-2): blocks two pathways
- Emicizumab-type (FIXa x FX): assembles an enzyme complex
- Zenocutuzumab (HER2 x HER3): blocks HER3 signaling
A format-based taxonomy groups them together.
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Sep 21, 2026 · 9:06 AM UTC
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We describe the difference with four primitives:
Sensor: reads an input
Gate: evaluates a permission condition
Processor: turns the decision into a physical molecular event
Actuator: produces the application-level output
Format and logic are separable axes.
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We mapped published technologies onto this vocabulary, from conventional antibodies to de novo switches.
Each assignment has an evidence status and a confidence level. Where evidence is thin, it says "uncertain" rather than inferring from marketing terms.
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The manuscript and the mapping table (Table S1) are open under CC BY 4.0. Not peer reviewed.
Disagreement with an assignment is the most useful feedback. Please open an issue.
DOI: doi.org/10.5281/zenodo.22868…
GitHub: github.com/sakakicr/protein-…
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