Cell Chemical Biology@CellChemBiol

Insights that drive innovation. Cell Chemical Biology is a #chemicalbiology journal from @CellPressNews. Editor-in-Chief @DeyMishtu

 Cambridge, MA
cell.com/cell-chemical-biolo…
Joined April 2014
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Online now! Chemoproteomic profiling of itaconate-derived protein modifications dlvr.it/TVf69p #chembiol

Chemoproteomic profiling of itaconate-derived protein modifications

Wang et al. herein review recent progress in the systematic identification of post-translational modifications and non-covalent interactions mediated by the immunomodulatory metabolite itaconate...

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Online now! Crk/Crk-L-mediated Rapgef1 recruitment couples MuSK signaling to AChR anchoring at the neuromuscular junction dlvr.it/TVcRN5 #chembiol

Crk/Crk-L-mediated Rapgef1 recruitment couples MuSK signaling to AChR anchoring at the neuromuscu...

Using proximity labeling, Barresi et al. defined the MuSK signaling network at the neuromuscular junction (NMJ) and identified 74 associated proteins. Crk-L emerged as an early signaling hub, while...

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Online now! G protein diffusion states reveal receptor binding dynamics at single-molecule scale dlvr.it/TVbZW5 #chembiol

G protein diffusion states reveal receptor binding dynamics at single-molecule scale

Mathiasen et al. provide a diffusion-based single-molecule approach for studying how G protein-coupled receptors engage G proteins in living cells. Native interactions are not resolved at 15 ms, but...

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Online now! A STING inhibitor suppresses ferroptosis through radical-trapping antioxidant activity dlvr.it/TVZkmN #chembiol

A STING inhibitor suppresses ferroptosis through radical-trapping antioxidant activity

(Cell Chemical Biology 33, ▪▪–▪▪.e1–e6, December 17, 2026)

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Oncogene activation mechanism determines the limits of targeted protein degradation dlvr.it/TVXDct

Oncogene activation mechanism determines the limits of targeted protein degradation

Gudauskaitė et al. show that the mechanism driving oncogenic protein overexpression influences the effectiveness of targeted protein degradation. While stabilizing mutations do not limit protein...

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A designer saxitoxin-engineered sodium channel pair as a general tool for subtype-selective inhibition dlvr.it/TVXD4b

A designer saxitoxin-engineered sodium channel pair as a general tool for subtype-selective...

Park et al. describe a high precision, small molecule tool patterned after a natural toxin for acute, selective, and reversible inhibition of an engineered voltage-gated sodium channel. By combining...

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Quantitative profiling of RNA modifications enriched in non-membrane-bound cellular structures using APEX-RNA-MS dlvr.it/TVXCMl

Quantitative profiling of RNA modifications enriched in non-membrane-bound cellular structures...

Seo et al. develop APEX-RNA-MS, a strategy integrating proximity labeling and nucleoside mass spectrometry, to characterize the spatial distribution of modified RNAs within human cells. They profile...

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Mechanistic dissection of SMARCA2/4 molecular glues reveals programmable switching between DCAF16 and FBXO22 dlvr.it/TVXBjc

Mechanistic dissection of SMARCA2/4 molecular glues reveals programmable switching between DCAF16...

Rouhimoghadam et al. demonstrate that single-atom chemical edits can reprogram E3 ligase selection by molecular glue degraders. By revealing that only specific ternary complex geometries drive...

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GLP-1R and GIPR crosstalk modulates insulinotropic signaling pathways dlvr.it/TVX9tZ

GLP-1R and GIPR crosstalk modulates insulinotropic signaling pathways

Lindquist et al. show that GLP-1 and semaglutide, but not exendin 4 or GIP, selectively drive GLP-1R-GIPR heterodimerization, altering receptor trafficking and signaling. These findings uncover a...

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Dual-function PROTAC suppresses ferroptosis and restores neuronal function via brain-targeted delivery dlvr.it/TVX957

Dual-function PROTAC suppresses ferroptosis and restores neuronal function via brain-targeted...

Ma et al. develop a dual-function PROTAC that degrades ACSL4 to reduce PUFA-containing membrane phospholipids while activating the PPARγ antioxidant pathway to enhance cellular antioxidant defense....

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Nitrated fatty acids form membrane biochemical capacitors that restrain inflammation dlvr.it/TVX88y

Nitrated fatty acids form membrane biochemical capacitors that restrain inflammation

Endogenous mechanisms that restrain inflammation remain incompletely understood. Colussi et al. identify membrane phospholipids as reservoirs of endogenous nitrated fatty acids that are rapidly...

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N-acetyltransferase 10 regulates chemokine expression in keratinocytes and promotes atopic dermatitis dlvr.it/TVX7JW

N-acetyltransferase 10 regulates chemokine expression in keratinocytes and promotes atopic dermat...

Shao et al. identified NAT10-mediated RNA acetylation as a key epitranscriptomic regulator of atopic dermatitis. NAT10 stabilized RELB mRNA to coordinate a pro-inflammatory checkpoint in keratinocy...

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NAT10 promotes keratinocyte-neutrophil crosstalk in atopic dermatitis dlvr.it/TVX6GG
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Signaling of glycoRNAs to Siglec-11 protects neurons by suppressing NF-κB dlvr.it/TVX5Rj

Signaling of glycoRNAs to Siglec-11 protects neurons by suppressing NF-κB

Excessive and sustained neuroinflammation can cause neuronal damage. Wang et al. show that neuronal glycoRNAs bind Siglec-11 on immune cells, suppressing NF-κB and inflammatory cytokines and protec...

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Cell-surface glycoRNAs put the brakes on neuroinflammation dlvr.it/TVX4LN

Cell-surface glycoRNAs put the brakes on neuroinflammation

Cell-surface glycoRNAs are emerging as neuroimmune signals. In this issue of Cell Chemical Biology, Wang et al. showed in co-culture that neuronal glycoRNAs engaged microglial Siglec-11, increased...

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The September issue of Cell Chemical Biology is live! Check out the latest advances in targeted protein degradation, RNA biology, inflammation, neurobiology, signaling, and more. dlvr.it/TVX23p
September issue cover of Cell Chemical Biology, mountains

ALT September issue cover of Cell Chemical Biology, mountains
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Online now! Rapamycin targetome mining identifies RBBP7 as a druggable epigenetic vulnerability in hepatocellular carcinoma dlvr.it/TVVBMy #chembiol

Rapamycin targetome mining identifies RBBP7 as a druggable epigenetic vulnerability in hepatocell...

Gao et al. identify RBBP7 as a rapamycin target that regulates histone H4 acetylation. Guided by this mechanism, they develop RBBP7-targeting peptides that suppress tumor growth and enhance the...

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Join keynote Craig Crews, @Yale University, and an exceptional international group of scientists at #CPSUndruggable2027 in Oxford, UK. Explore the science redefining what’s possible in drug discovery. hubs.li/Q04xpTFw0
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Online now! Neuronal translational control in physiology, infection, and inflammation dlvr.it/TVTHMK #chembiol

Neuronal translational control in physiology, infection, and inflammation

Neurons rely on local translational control to rapidly adapt protein synthesis across their complex architecture. Fischbach and Grosshans et al. highlight how the integrated stress response maintains...

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Online now! DPP3 restrains the non-canonical inflammasome through PEBP1 cleavage dlvr.it/TVPQhl #chembiol

DPP3 restrains the non-canonical inflammasome through PEBP1 cleavage

Li et al. identify DPP3 as a natural brake on the non-canonical inflammasome. DPP3 cleaves PEBP1 to produce a fragment that directly inhibits caspase-4/11. Zinc chelators block DPP3 to potentiate...

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