Cell Reports@CellReports

Cell Reports is an open-access journal at Cell Press, publishing weekly. Tweets by Cell Reports editors.

 Cambridge, MA, USA
cell.com/cell-reports/home
Joined July 2011
2,040 Photos and videos
Navigation strategies predict spatial memory and hippocampal recruitment dlvr.it/TVfM9h

Navigation strategies predict spatial memory and hippocampal recruitment

Patai, E.Z. et al. show via analyzing spontaneous navigation behavior that humans are idiosyncratic, flexibly adapt strategies to variable degrees to achieve learning, and that strategies do not...

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LiP-MS reveals a feedback loop of tomato UDP-glucosyltransferases managing bioactive jasmonate homeostasis dlvr.it/TVfHRw

LiP-MS reveals a feedback loop of tomato UDP-glucosyltransferases managing bioactive jasmonate...

Venegas-Molina et al. demonstrate the utility of limited proteolysis-coupled mass spectrometry (LiP-MS) for the discovery of plant metabolite-binding proteins by identifying enzymes that glycosylate...

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Myeloperoxidase and anti-MPO IgG synergistically enhance TLR9-mediated immune activation in ANCA-associated vasculitis dlvr.it/TVfFBh

Myeloperoxidase and anti-MPO IgG synergistically enhance TLR9-mediated immune activation in...

Anti-myeloperoxidase (MPO) IgG drives ANCA-associated vasculitis by activating neutrophils. Krollmann et al. demonstrate that, beyond neutrophil activation, anti-MPO IgG facilitates TLR9-dependent...

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DDX39A unwinds viral RNA G-quadruplexes to limit α-Synuclein amyloidogenesis dlvr.it/TVf7DH

DDX39A unwinds viral RNA G-quadruplexes to limit α-Synuclein amyloidogenesis

Jain et al. demonstrate that RNA helicase DDX39A regulates α-Synuclein amyloidogenesis by unwinding RNA G-quadruplexes (rG4s) and that viral rG4s accelerate this aggregation by perturbing α-Synucle...

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FluxAtlas is a pan-cancer metabolic flux atlas that identifies tumor-selective dependencies and prognostic biomarkers dlvr.it/TVf2kv

FluxAtlas is a pan-cancer metabolic flux atlas that identifies tumor-selective dependencies and...

Kohli et al. apply enzyme- and nutrient-constrained genome-scale modeling to more than 10,000 tumors across 28 cancer types, defining a pan-cancer metabolic-flux landscape. This analysis reveals...

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Increased extracellular fluid viscosity drives M2-like macrophage polarization to promote breast cancer progression and immunotherapy resistance dlvr.it/TVdznq

Increased extracellular fluid viscosity drives M2-like macrophage polarization to promote breast...

Zhang et al. demonstrate that increased extracellular fluid viscosity promotes immunosuppressive M2-like macrophage polarization through integrin/FAK-STAT3 signaling and cytoskeletal remodeling. This...

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A bifunctional ARHGEF17-AS1 locus encodes MSEP, a protein that supports mitotic spindle organization dlvr.it/TVdwNN

A bifunctional ARHGEF17-AS1 locus encodes MSEP, a protein that supports mitotic spindle organization

Mahale et al. identify MSEP, a protein encoded within the ARHGEF17-AS1 antisense locus, and show that it localizes to the mitotic spindle and supports spindle organization through a TPX2-associated...

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Biased connectivity shapes food odor categorization in the Drosophila mushroom body dlvr.it/TVdXxp

Biased connectivity shapes food odor categorization in the Drosophila mushroom body

Chan et al. show that individual Kenyon cell types in the Drosophila associative learning center, the mushroom body, encode odors according to different principles. Biased projection-neuron input...

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Cell volume regulation in metazoans involves phosphorylation of TSC22D proteins dlvr.it/TVdSsp

Cell volume regulation in metazoans involves phosphorylation of TSC22D proteins

Lee et al. describe a condensate-based signaling mechanism regulating cell volume homeostasis. TSC22D, WNK, and NRBP proteins form dynamic condensates that modulate WNK-SPAK/OSR1 signaling. WNK-dep...

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MCUB restricts mitochondrial calcium to support metabolic adaptation and homeostasis in glioblastoma dlvr.it/TVdQSs

MCUB restricts mitochondrial calcium to support metabolic adaptation and homeostasis in glioblastoma

Sun et al. find that hypoxia-induced MCUB promotes a restricted mitochondrial Ca2+ flux state that supports metabolic adaptation and mitochondrial homeostasis in glioblastoma. Targeting MCUB-depend...

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Matrix viscoelasticity amplifies pro-fibrotic crosstalk between cardiac fibroblasts and macrophages dlvr.it/TVdCcn

Matrix viscoelasticity amplifies pro-fibrotic crosstalk between cardiac fibroblasts and macrophages

Matrix viscoelasticity governs cardiac fibroblast-macrophage crosstalk, with soft, viscous environments amplifying profibrotic signaling through dynamic paracrine feedback. Atcha et al. examine how...

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Placental trophoblasts exhibit iron dysregulation and ferroptosis signaling associated with SARS-CoV-2 restriction dlvr.it/TVd8T5

Placental trophoblasts exhibit iron dysregulation and ferroptosis signaling associated with...

McColl et al. demonstrate that SARS-CoV-2 impairs placental iron efflux, leading to persistent iron accumulation and impaired maternal-fetal iron transfer, and activates ferroptosis signaling, which...

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Topoisomerase I inhibition yields a CD74high/MHChigh human microglial subtype with enhanced Aβ uptake dlvr.it/TVd4hh

Topoisomerase I inhibition yields a CD74high/MHChigh human microglial subtype with enhanced Aβ...

Camptothecin and its analog Topotecan drive human microglia toward a CD74high/MHChigh state with enhanced amyloid-β phagocytosis and altered inflammatory signaling. Using cell, organoid, and zebraf...

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Role of the pulvinar in early visual cortical signaling in the macaque dlvr.it/TVccxp

Role of the pulvinar in early visual cortical signaling in the macaque

Using simultaneously recorded population spiking activity in the macaque pulvinar and early visual cortical areas V1 and V2, Xu et al. evaluate signaling motifs among these three structures. They...

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piRNA-mediated silencing of exogenous retrovirus in mouse spermatogonial stem cells dlvr.it/TVcZlT

piRNA-mediated silencing of exogenous retrovirus in mouse spermatogonial stem cells

Shiromoto et al. show that PIWI-interacting RNAs and TRP53 protect mouse spermatogonial stem cells from exogenous retroviral infection. Disruption of this pathway enhances viral expression and...

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Dietary α-ketoglutarate modulates lung adenocarcinoma growth and epigenetic remodeling in a sex-dependent fashion dlvr.it/TVcMbK

Dietary α-ketoglutarate modulates lung adenocarcinoma growth and epigenetic remodeling in a...

Alcaraz Jr. et al. show that dietary supplementation with calcium-αKG modulates lung cancer epigenetics and transcriptional programs in a sex-dependent way, resulting in reduced tumor growth in...

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Alternate day fasting attenuates metabolic dysfunction-associated arterial thrombotic risk via increasing indole-3-propionic acid dlvr.it/TVcJKZ

Alternate day fasting attenuates metabolic dysfunction-associated arterial thrombotic risk via...

Feng et al. show that alternate day fasting attenuates metabolic dysfunction-associated arterial thrombosis by gut microbiota reshaping. They identify the microbial metabolite indole-3-propionic acid...

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Structured and target-specific development of cortico-cortical connectivity in the mouse visual cortex dlvr.it/TVcDk5

Structured and target-specific development of cortico-cortical connectivity in the mouse visual...

Jacobs and Ratliff et al. show how V1 wiring to eleven higher visual areas develops in mouse cortex through directed, region-specific targeting: medial areas innervate early and refine gradually into...

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SDCBP competes with CBL to stabilize PES1 and promote c-Myc translation in ESCC tumorigenesis dlvr.it/TVbrhC

SDCBP competes with CBL to stabilize PES1 and promote c-Myc translation in ESCC tumorigenesis

Xiao et al. demonstrate that SDCBP drives esophageal squamous cell carcinoma progression by preventing CBL-mediated ubiquitination and degradation of PES1. Stabilized PES1 enhances pre-rRNA process...

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A USP28-BRD4 axis contributes to the acceleration of breast cancer growth by hyperglycemia dlvr.it/TVbkBK

A USP28-BRD4 axis contributes to the acceleration of breast cancer growth by hyperglycemia

How diabetes promotes cancer progression remains poorly understood. Li et al. show that high blood glucose stabilizes a cancer-promoting protein, BRD4, through a molecular switch involving USP28 and...

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