Ion Channel Biophysicist. Loves greasy proteins. Fluorescence spectroscopy, Single molecule dynamics, Electrophysiology, Thermodynamics.
St. Louis, MO, USA
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Calling all pre and postdoc trainees. Please consider applying for SGP Rising Star Travel awards. Follow the link for details
Announcing the second round of 2025 SGP Rising Star Travel Awards for students and postdocs. The $500 awards can be used for meetings held up to 1 year from notification. Apply today! Deadline: 31 December 2025 sgpweb.org/awards/risingstar
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Baron Chanda retweeted
Announcing the second round of 2025 SGP Rising Star Travel Awards for students and postdocs. The $500 awards can be used for meetings held up to 1 year from notification. Apply today! Deadline: 31 December 2025 sgpweb.org/awards/risingstar
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Baron Chanda retweeted
Our DeFrND approach is finally published. A simple trick to isolate membrane proteins with native lipids for structural and functional characterization. doi.org/10.1038/s41467-025-6…
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Our latest Excelsior awardee!! Congratulations, Jessica!
We are delighted to announce that Dr. Jessica Caldwell @JLCaldwellPhD has received the 2025 SGP Excelsior Award! Dr. Caldwell vividly exemplifies the mission of our Society and the future of physiology and biophysics. Learn more sgpweb.org/awards/excelsior.
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Baron Chanda retweeted
Tickets to the 12th JGP-SGP Mixer are going fast! Join us in LA to connect with fellow SGP members. There is no charge to attend, but you must be an SGP member and register at sgp-jgp2025mixer.eventbrite.…. To join SGP, please visit sgpweb.org/membership.
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Baron Chanda retweeted
SGP congratulates Dr. Huanghe Yang on receiving the 2025 Paul F. Cranefield Award for his outstanding paper, “Niclosamide potentiates TMEM16A and induces vasoconstriction” doi.org/10.1085/jgp.20231346…
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Baron Chanda retweeted
SGP congratulates Dr. Man Si on receiving the 2025 Cranefield Postdoctoral Fellow Award for her outstanding paper, “Epilepsy-associated Kv1.1 channel subunits regulate intrinsic cardiac pacemaking in mice” doi.org/10.1085/jgp.20241357…
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Baron Chanda retweeted
SGP congratulates Dr. Rachael Lucero on receiving the 2025 Cranefield Student Award for her outstanding paper, “Transport of metformin metabolites by guanidinium exporters of the small multidrug resistance family” doi.org/10.1085/jgp.20231346…
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1) Excited to share our latest research uncovering a novel conformation-specific binding site for propofol in the voltage sensor domain (VSD) of HCN1 ion channels.
science.org/doi/10.1126/scia…
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2) This work not only advances our understanding of HCN channel modulation but also lays the groundwork for developing isoform-specific analogs of propofol as targeted analgesics.
A huge thank you to the talented team of collaborators.
@AlexEversLab @veburts @johncowgill11
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Happy to introduce DeFrND: designer peptide scaffolds to enable detergent-free reconstitution of membrane proteins with native lipids into nanodiscs for biochemical and structural studies. Let me know if you would like to try it.
biorxiv.org/content/10.1101/…
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Jon Lorsch's blog post:
“One major barrier to entry into new markets is the requirement to see the future with clarity. It has been said that to foretell the future, one has to invent it. To be able to invent the future is the dividend that basic research pays.” Wong 1996
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Baron Chanda retweeted
Just 3 weeks until SGP 2024! You can still submit an abstract to present a poster if you🚨submit and register by 15 August at sgp2024.com🚨Join us to hear great talks by Rachelle Gaudet @RachelleGaudet, Josefina del Mármol @MarmolJosefina, and many more!
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One of the unforgettable moments at the 2024 Ion Channels GRC was the closing lecture by Fred Sigworth. If you missed it, here it is.. piped.video/db1afWzokOU?si=hyCJ…
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A timely meeting focused on molecular evolution of membrane receptors!
🚨Register for the 77th @sgpweb Meeting🚨, ⭐️"Molecular Evolution in the Membrane: Ion Channels, Transporters, and Receptors"⭐️ Want to be considered for a short talk? Submit your abstract by 🗓️1 August! For more info and to register, visit sgp2024.com.
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Structures of channels in Open conformation are rare. Thrilled to share our latest manuscript..
Structural basis for hyperpolarization-dependent opening of human HCN1 channel disq.us/t/4p78xec
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Perhaps the most unexpected feature of the structure is the helix-coil transition at the electromechanical coupling interface. Coincidentally, in the dark ages, before we had any structures of ion channels, such a model for voltage-dependent activation was considered!!
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