Circulation: Heart Failure is a journal of the American Heart Association. Editor-in-Chief: Nancy Sweitzer, MD, PhD. RT/follows do not imply endorsement.
🫀↔️🫘Kidney injury in #CardiogenicShock is more than a consequence of low cardiac output
Venous congestion, microcirculatory dysfunction, inflammation, neurohormonal activation, &shock therapies contribute
A contemporary look at AKI as a heterogeneous component of shock biology
#CardiogenicShock may begin before hypotension becomes obvious
In acute HF, rising venous pressure, impaired microcirculation, inflammation, &progressive hypoperfusion can drive a gradual transition toward shock.
Recognizing this continuum early may be critical 🫀
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Health-related quality of life improved more after heart transplantation than after long-term mechanical circulatory support over time
ahajrnls.org/3T0BROz
Heart failure involves neurocognitive disorders via hypoperfusion and inflammation; multidisciplinary care helps. See State-of-the-Art @CircHFahajrnls.org/3UZ1aRI
📌Featured in the @CircHF Cardiogenic Shock Issue:
Cardiogenic shock mortality remains 40-50% despite modern care. The path forward isn't trials vs observational studies — it's building an integrated evidence ecosystem ahajournals.org/doi/full/10.…@ChristinaLalani@rwyeh@SmithBIDMC
What should a true regional #CardiogenicShock system look like?
A proposed node-based model gives each hospital a defined role, w/transfer driven by physiology, trajectory, and candidacy for an exit strategy—not geography alone
(Read More ⬇️)
Not all #CardiogenicShock is simply “low output”
Vasodilatory phenotype adds another layer of complexity w/reduced vascular resistance complicating hemodynamic assessment &mgmt
A focused review of this challenging &increasingly recognized shock phenotype bit.ly/3TcT73a
Read the recent @CircHF Editor's Perspective 📝by @DrNancySweitzer & Dr. James Fang introducing the journal's focus issue:
Cardiogenic Shock in Evolution: A Special Dedicated Issue of Circulation: Heart Failure Guest Edited by David A. Morrow, MD, MPH
🔗ahajournals.org/doi/full/10.…
📌The issue highlights the spectrum of cardiogenic shock, from preshock states to pts in extremis
📌Authors teased out nuances of current phenotypic classification, explored major complications of shock and described promising and emerging treatments and processes of shock care