Circulation Research@CircRes

Circulation Research is an AHA journal focusing on basic science & translational cardiovascular research. instagram.com/CircRes/ facebook.com/CircRes

ahajournals.org/journal/res
Joined October 2009
2,934 Photos and videos
Wang & colleagues found that #colitis-associated gut #microbiota-derived LPS reprograms immune cells to release GBP2b/GBP1-containing #exosomes that promote #CardiacHypertrophy. Learn more at ahajrnls.org/3V7wU7f
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ICYMI: the latest episode of #DiscoverCircRes is out! ahajrnls.org/4yqSJx2 @StHilaireLab chats with @ImmunologyAU about their study, "Increased Autoreactive CD8+ T Cells to Apolipoprotein B Epitopes in Patients with Severe Coronary Artery Disease" bit.ly/4gT2TPB@MCG_AU
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@CircRes Sept 25th Issue is Out! ahajrnls.org/3wPOBJJ Cover: Illustration of the gut-heart axis in chronic colitis, showing how microbiota-derived signals reprogram circulating immune cells & promote immune-cell and exosome-mediated communication with the heart.
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Wei & colleagues found that loss of #desmoplakin (DSP) in fibroblasts leads to exaggerated #fibrogenesis in DSP-cardiomyopathy. Learn more about the role of #autophagy in plaque formation at ahajrnls.org/478ertJ @DrJMarine @ASaguner
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1/5 New @CircRes podcast #DiscoverCircRes linkly.link/2tapA @StHilaireLab chats with @ImmunologyAU about their study, “Increased Autoreactive CD8+ T Cells to Apolipoprotein B Epitopes in Patients with Severe Coronary Artery Disease” bit.ly/4gT2TPB@MCG_AU
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4/5 Mast Cell St8sia1 Is a Glyco-Epigenetic Checkpoint Driving Cardiac Remodeling by Zhou et al bit.ly/3UZ8wEA

Mast Cell St8sia1 Is a Glyco-Epigenetic Checkpoint Driving Cardiac Remodeling | Circulation Research

BACKGROUND: Pathogenic immune-cardiac crosstalk underlies maladaptive remodeling in chronic heart failure, yet therapies directly targeting this axis are lacking. Glycoconjugates, which are crucial...

ahajournals.org
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5/5 Natural ERRα Activator Formononetin Ameliorates Anthracycline Cardiotoxicity via Metabolic Improvement by Wang et al bit.ly/4gQ6f5W

Natural ERRα Activator Formononetin Ameliorates Anthracycline Cardiotoxicity via Metabolic Improv...

BACKGROUND: Anthracycline-induced cardiotoxicity (AIC) limits life-saving chemotherapy and is driven by early metabolic remodeling. The nuclear receptor ERRα (estrogen-related receptor α) is a master...

ahajournals.org
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Wang & colleagues found a natural #isoflavone protects the heart from chemotherapy induced cardiotoxicity & enhances #doxorubicin's #antitumor activity. Learn more at ahajrnls.org/3Vf4Hex
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Peng & colleagues identified a protein that clears clogged transport routes to #mitochondria, offering a promising new strategy to restrain pathological #CardiacHypertrophy & the progression of #HF. Learn more at ahajrnls.org/4hm5gMh @dutlai
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Zhou & colleagues found that mast cell restricted ganglioside #GD3 synthase functions as a glycol-epigenetic checkpoint driving maladaptive cardiac remodeling. Learn more about preventing #HeartFailure at ahajrnls.org/46VP1iW
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@CircRes Sept 11th Issue is Out! ahajrnls.org/3wPOBJJ Cover: Mast cell ganglioside GD3 serves as a glyco epigenetic checkpoint, binding H2A.Z/H3.3C to drive adverse cardiac inflammatory & fibrotic remodeling.
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Li & colleagues found in a longitudinal #metabolomic study blood metabolites associated with future #HF, with changes detectable up to 20 years before diagnosis & varying across metabolic disorders. Learn more at ahajrnls.org/4yqr3Z1
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The study by Roy et al reveals how the immune system contributes to #atherosclerosis. These findings may enable new antigen-specific approaches for treatment of #CVD. Learn more at ahajrnls.org/4ytxeeV @ImmunologyAU @MCG_AU @IrLeBar
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The study by Zheng et al reveals that tertiary lymphoid structures form in brain #aneurysm walls & are associated with rupture. Blocking #CXCL13 signaling pathway reduced aneurysm formation & rupture in a mouse model. Learn more at ahajrnls.org/4gM4U1r
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Guo & colleagues found that plasma soluble #TREM2 promotes pro-atherogenic #myeloid recruitment & inflammatory #macrophage activation. Learn more about targeting #HSP90β for therapy at ahajrnls.org/45YP7WK
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Thürmann et al found in teenagers diastolic high #BP was linked to a distinct #inflammatory protein pattern in urine, which may signal early changes related to future #CV or #kidney disease. Learn more at ahajrnls.org/4xvBWbJ
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ICYMI: the latest episode of #DiscoverCircRes is out! ahajrnls.org/4gu7Gbu @StHilaireLab chats with Drs. @jonathankirk, Laura A. Sherer, and @abbynagle about their study "Contractility Drives Cardiomyocyte Maturation and the Response to Nanopatterns" bit.ly/4xlPSF1
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Men et al found in #HFpEF stressed cardiomyocytes release small #EVs enriched with #miR-200c-3p that travel to the #hypothalamus, where they activate microglia & trigger #neuroinflammation & excessive sympathetic outflow. Learn more at ahajrnls.org/46fy42V
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