Geneticist, TE/ERVist, chromatin nerd, embryology fanboy, repro bio, opera/schnauzer/brunch connoisseur. 🏳️🌈46XY. FIRBee2016 Mizzou-Stanford-Utah, now: UTSW
Dallas, Texas
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Excited to share our work on chromatin landscape remodeling in cloned embryos! 🐄🐄We started off w/ simple question: how does the somatic epigenome reprogram to prepare for the onset of transcription (EGA)? tinyurl.com/yc4wv76p
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TWiV 1361: Ancient Viral Sword and Shield 🗡️🛡️ TWiV explains discovery of a previously unknown mechanism of RNA-guided DNA recognition for genetic control that possibly predates the emergence of CRISPR pathways, & more. 📺 bit.ly/4z0J40j
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Edward Grow, PhD retweeted
ed sheeran, your silence on greenfield lesbian bar is deafening
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Spoiler alert: you have two brains. The front of your brain and the back of your brain were never the same organ. They start as two different cells, in two different places, and they have been separate lineages for something like 550 million years.
doi.org/10.1038/s41593-026-0…
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Nail in the coffin of the DNA:cytoplasmic ratio as a control of ZGA timing in mammals.
DNA replication is dispensable for developmental progression, but required for heterochromatin organization at mouse zygotic genome activation biorxiv.org/content/10.64898…
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Edward Grow, PhD retweeted
I'm going to start a licensing program for bio dooming where we march applicants into a lab and force them to stitch together a 10kb construct from oligos with only a chatbot as a coach.
To make it realistic we'll employ jaded postdocs as proctors to belittle them ruthlessly.
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Edward Grow, PhD retweeted
SWI/SNF associates with RNAPII PIC, Mediator, and nucleosome to form a 7 MDa complex:
Structural basis of a SWI/SNF-associated transcription pre-initiation complex sciencedirect.com/science/ar…
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Edward Grow, PhD retweeted
Join us at @biohub NY to develop new spatiotemporal technologies together by combining synthetic biology with imaging-based multi-omics!
(New) We are looking for a Postdoctoral Fellow/Scientist I (Imaging Technology) to join our growing team @biohub NY and develop and apply spatiotemporal multi-omics technologies for resolving cell state dynamics!
job-boards.greenhouse.io/bio…
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Edward Grow, PhD retweeted
The vast majority of immigrants with U.S. STEM PhDs use the OPT program to stay in the country. The world has a shortage of people with these skills. It is our advantage that they're drawn to our university STEM programs--which are the best in the world.
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Edward Grow, PhD retweeted
No one in the upper administration is requiring this. And it not required by law or demanded by the board of regents.
Just to be safe we want to go above and beyond when it comes to compliance!
Proudly, this college has always been about overachieving on rules & regulations!
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Edward Grow, PhD retweeted
Online today @ScienceMagazine Noncoding transcription controls the developmental dynamics of long-range gene regulation | Science science.org/doi/10.1126/scie…
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Edward Grow, PhD retweeted
We are hiring! Please apply and spread the word!
🔔 We are hiring! 🔔 We are looking for great colleagues doing curiosity driven research at the molecular level across broad areas of science. Please consider applying and spread the word!
recruit.apo.ucla.edu/JPF1130…
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Edward Grow, PhD retweeted
Cool, its finally out. Base editing in human embryos! nature.com/articles/s41586-0…
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Edward Grow, PhD retweeted
🔥Does academia stifle creativity? This new perspective argues that academia is currently structured to select against creativity, intellectual risk-taking and bold ideas. Young scientists – who may be best positioned for new ideas – are particularly incentivized to play it safe.
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Edward Grow, PhD retweeted
Really enjoyed reading this excellent and thought-provoking new review on long-range enhancer-mediated gene regulation:
nature.com/articles/s41588-0…
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Cool finding re: many protein coding AA changes result in fitness costs due to likely disrupting protein/protein interaction surfaces. Wonder if this hold true in a more buffered (complex) system?
this is such a beautifully humbling experiment. phage ϕx174 has just 5,386 bases encoding 11 proteins—about as small and well-studied a biological system as you could ask for. mutate every nucleotide and ask what happens. even here, ~25% of damaging mutations have no mechanistic explanation. and ai predictors didn’t do particularly well. we can read biology. we can increasingly perturb biology. but we are still a long way from understanding biology.
science.org/content/blog-pos…
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Edward Grow, PhD retweeted
I'd like to take this opportunity to thank all of the individuals who have published bogus, incorrect, misleading and incomplete data sets, wrecking the biology literature. This is very helpful in keeping the AI Agents from rendering me obsolete. Much appreciated.
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Edward Grow, PhD retweeted
(New) We are looking for a Postdoctoral Fellow/Scientist I (Imaging Technology) to join our growing team @biohub NY and develop and apply spatiotemporal multi-omics technologies for resolving cell state dynamics!
job-boards.greenhouse.io/bio…
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