Collaborative #research center based @Cornell directed by @DrMaureenHanson encompassing a variety of projects on #MECFS. Visit our website below for more info.
🏆 Congrats to Center investigator Dr. Erin Wissink for winning 1st place Outstanding Oral Presentation Award at #YoungEMERG! Her talk "Cytotoxic T cell dysregulation in #MECFS" presented findings on T cell metabolism and mTOR signaling from our single-cell genomics research.
💡 Join the fight to understand ME/CFS! 💡
NYC study recruiting:
🩺 People with ME/CFS
💪 Healthy controls
⚠️ Don’t share personal/health info here. Contact us directly with questions.
🔗 Learn more: neuroimmune.cornell.edu/rese…
❤️ Spread the word! #MECFS#ResearchMatters
ALT Recruitment flyer: Join a study of muscle and cellular function in ME/CFS. Eligible: adults 18–70 with ME/CFS. Not eligible: ME/CFS onset on/after Jan 2020; lingering COVID 19; smoker/tobacco use; pregnant or breastfeeding; significant medical illness (e.g., severe asthma, uncontrolled hypertension, HIV, autoimmune disease, diabetes); current blood thinners; problematic alcohol or drug abuse; unwilling to avoid aspirin/NSAIDs 4 days, stop supplements 2 weeks, or stop cannabis 2 weeks; history of hospitalization for mental illness. Tasks: 15 min phone call; ~90 min health/medical history and physical activity questionnaires; clinic visit ~3 hrs with vitals, urine, EndoPAT, handgrip test, blood draw, muscle biopsy. Location: Hospital for Special Surgery, New York, NY. $400 upon completion; reports of blood circulation, handgrip strength, and metabolic and immune profiles. Total time ~4–4.5 hrs (excluding travel). Contact: 607 255 7244. More: neuroimmune.cornell.edu/research/.
ALT Recruitment flyer: Join a study of muscle and cellular function in healthy adults 18–70. Not eligible: lingering COVID 19; smoker/tobacco use; pregnant or breastfeeding; significant medical illness (e.g., severe asthma, uncontrolled hypertension, HIV, organic brain impairment, autoimmune disease, diabetes); blood thinners; alcohol or drug abuse; unwilling to avoid aspirin/NSAIDs 4 days, stop supplements 2 weeks, or stop cannabis 2 weeks; diagnosed with depression; hospitalization for mental illness; exercise 4+ days/week for 30+ min or a physically demanding job. Tasks: 15 min phone call; 90 min health/medical history and physical activity questionnaires; clinic visit 3 hrs with vitals, urine, EndoPAT, handgrip test, blood draw, muscle biopsy. Location: Hospital for Special Surgery, New York, NY. $400 upon completion; reports of blood circulation, handgrip strength, and metabolic & immune profiles. Contact: 607 255 7244; More information: neuroimmune.cornell.edu/research/
Center researchers performed longitudinal plasma proteomics (SomaScan7K ) in 79 #MECFS vs 53 controls around two maximal CPETs. Findings: Persistent immune & metabolic dysregulation in recovery, linked to PEM. Learn more on our website.
neuroimmune.cornell.edu/news…#PEM#Research
Today David Iu, a PhD student in Andrew Grimson's lab at the Cornell ME/CFS Center, passed his thesis exam. As well as co-authoring several published papers already, David will be completing another manuscript on immune cells in ME.
🔬 NEW from @CornellMECFS: Study reveals protein changes in #MECFS using blood-derived extracellular vesicles. First analysis in male patients shows altered EV cargo dynamics post-exercise.
🔓 Read: doi.org/10.1002/ctm2.70346
📊 Data: mapMECFS.org
Analysis shows impaired energy metabolism, upregulated complement system, and dysregulated protein folding. Proteomic changes were associated with ME/CFS patients’ post-exertional malaise, unrefreshing sleep, and functional capacity.
🔍 New study from Center examines role of autoantibodies in #MECFS. 🧪 Using advanced screening of 7,500+ antibody-antigen interactions in 172 participants, researchers found no significant differences between patients & controls. 📄 Read more: doi.org/10.3390/ijms26062799
📢 New insights into #MECFS: Research from our Center reveals how T cells become exhausted in ME/CFS patients. 🧬 Learn more about the study and its implications in the @CornellChronicle article: news.cornell.edu/stories/202…#TCells#Immunology
Check out our website's news feed (link below) for a post regarding the recent #MECFS#CPET paper by Betsy Keller et al. out in the Journal of Translational Medicine. 👉neuroimmune.cornell.edu/news…
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Cornell Center for Enervating NeuroImmune Disease retweeted
It was great to see former graduate student Jessica Maya at the InvestinME meeting. She is continuing ME/CFS research as a postdoctoral fellow at CDC in Atlanta. She participated in the Young EMERG meeting.
I hope our op-ed in The Hill will raise awareness of the need for substantial funding for pre-pandemic ME/CFS. Treatments are needed for all infection-associated chronic conditions. thehill.com/opinion/4615604-…
The Center has a new publication out on single-cell transcriptomics in #MECFS. Congrats to the Grenier and Grimson labs and everyone that contributed! The paper is open access in Cell Reports Medicine. doi.org/10.1016/j.xcrm.2023.…
Results of a collaboration between the Cornell and Columbia NIH ME/CFS Centers have now been published in JTM. Analysis of plasma proteins and extracellular vesicle cytokines distinguishes ME/CFS from healthy at 86% accuracy. tinyurl.com/2yjjavdj