PAX8 positivity in lower urinary tract urothelial carcinoma (including different clones)! Seen in pTa & invasive alike.
Not just a peculiarity of upper tract urothelial Ca.
Important #IHCPath fact to be aware of imo
#GUPath#PathTwitter
#GUpath TURBT, prior high grade pTa PUC
yes there is some lovely PAX8 positive flat pattern nephrogenic adenoma, but you'll also notice background pTa PUC is ALSO PAX8 positive!
(NA was p63 neg; PUC was p63 pos)
⏬cont'd⏬
great Q! No minimum quant per say
I report any %, as long as it is def chorio (syncytios+admixed cytotrophs; often assoc w/hemm).
fortunately, per this paper limited chorio (<5%) likely not prognostic anyhow, but for completeness and to correlate with serum HCG I report any
This is as good an example of Crooke hyaline change as you'll ever see, from a patient with Cushing's disease. Note the concentric rings on CAM 5.2. #pathology#neuropath#PathTwitter