Clinical Oncologist at Oxford Cancer Centre and Associate Professor at the University of Oxford. @ChelseaFC fan. Opinions are mine.
Oxford, UK
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It should certainly be factored into the risk assessment. That RR (x1.5) would be roughly equivalent to 3-4 Gy of breast irradiation (depending on age @ treatment). Women treated with 300 mg/m2 would have a higher expected risk than many now recommended screening due to RT alone.
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Kind of puts the favourite manuscript line in studies demonstrating PFS a difference: "but no statistically significant difference in overall survival was seen" into perspective doesn't it? Nice data... All that is needed is time and numbers and one~the other.
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Many congrats to our team @Oxford_NDPH (Carolyn Taylor, David Dodwell, Paul McGale, @jake_probert, @GurdeepMannu, Amanda Kerr and Sarah Darby) plus our collaborators, on the publication of this paper. 😀Good news for patients!
bmj.com/content/381/bmj-2022…
bbc.co.uk/news/health-658822…
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Delighted to be part of this new project! 😀
We are also looking for a Clinical Fellow to work within the team. See ads:
tinyurl.com/NATCANNHLCF1
tinyurl.com/NATCANNHLCF2
A great opportunity for a haematology specialist trainee! Please consider applying.
We are delighted to introduce the sixth of the new NATCAN audits - the National Non-Hodgkin Lymphoma Audit. Follow the team to find out more @NNHLA_NATCAN @DavidJCutter @BritSocHaem @LymphomaAction @bloodcancer_uk
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Calling all Clinical Oncology trainees!📡🚨If you are interested in joining our team @Oxford_NDPH as a Research Fellow within our @CRUKresearch funded programme that aims to quantify the benefits and risks of cancer treatments then please take a look: tinyurl.com/BARCRF2 👀
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Great to see a whole session at #ESTRO2023 dedicated to shared decision making #sdm! Kicked off by @ArwenPieterse. An important concept in Haematology and Oncology where choices are often complex and patients views critical. The right information at the right time is 🗝️.
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What are the actual 5 year PFSs? Great to see but underpowered as expected. Need to answer 'should' RT be omitted (when benefit and risks balanced) rather than 'can'... Does this? What was the assumed difference for the non-inferority p-value?
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Been quite a while since I've carried one of these...
#PayRestoration #JuniorDoctorStrike
#SupportTheStrikes ✊
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Maybe just because people add chemotherapy which increases the toxicity?
redjournal.org/article/S0360…
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Not even to allow dose escalation for tumours next to sensitive structures or allowing radical treatment of extensive volumes that would otherwise be undeliverable? I thought it was these 3 things rather than it just being about reducing toxicity?
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And is much more relevant for lower dose treatments (e.g. lymphoma) than for lung cancer, where maximising cure rather than concern over late effects should take priority
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That is certainly true. Admittedly my comment was aimed primarily at the second example rather than the first...
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Would also be nice to see the RBE uncertainty around the Bragg peak falling across the heart/coronary arteries. Reassuring dose washes from imperfect algorithms aren't the whole story...
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Well done @GurdeepMannu !! 🎉
Using large datasets, @UniofOxford's @GurdeepMannu will use a Clinician Scientist Fellowship to identify ways to prevent #BreastCancer, improve post-treatment surveillance, translate existing research into the #clinic & streamline #RandomisedTrials [6/10]
ALT Clinician Scientist Fellowship - picture of Dr Gurdeep Mannu, University of Oxford. Research title: Pre-invasive and invasive breast cancer: from risk factors to optimal treatment
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Completely agree. The same arguments are used for early stage Hodgkin lymphoma. As if 'radiotherapy avoidance' is an end point in it's self! The EBCTCG meta-analyses suggest that with enough follow-up this reduction in recurrence is likely to become a c.2% improvement in OS.
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🚨This post also now on the BMJ website 🚨- tinyurl.com/BMJCORF. Please take a look and contact me or Carolyn Taylor - tinyurl.com/CTCRF - to discuss if you're interested 😀
#oncology #research #opportunity
Calling all Clinical Oncology trainees!📡🚨
If you are interested in joining our team @Oxford_NDPH as a Research Fellow within our @CRUKresearch funded programme that aims to quantify the benefits and risks of cancer treatments then please take a look tinyurl.com/BARCRF 👀🚀
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