Developmental Cell@Dev_Cell

We love (and publish) cell biology, development, and everything in between. Tweets by Dev Cell scientific editors bit.ly/19EEUcT

 Cambridge, MA
cell.com/developmental-cell/
Joined December 2013
212 Photos and videos
New issue! We cover developmental tempo, cancer cell competition, cardiac organoids, immune cell fate, cellular senescence, embryonic diapause, and plant circadian & reproductive biology. short.do/NQPVQF
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Online now: Self-organizing human dual neural organoids model regional disease defects and teratogenicity dlvr.it/TVXzNF #biology #science

Self-organizing human dual neural organoids model regional disease defects and teratogenicity

Lu et al. develop human neural organoids that recapitulate self-organized peripheral and central neural co-development. This model reveals Wnt signaling’s bidirectional role in fate determination,...

cell.com
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Hear Professor Jijie Chai (@Westlake_Uni) share his latest findings on hypersensitive response (HR) cell death mediated by non-NLR immune receptors @CellPressEvents #CSCellDeath26 📍Hangzhou, China 📆October 22–24, 2026 🔗Register: hubs.li/Q04w28HR0
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Online now: Chromatin context shapes SPT5 regulation of promoter-proximal Pol II, fine-tuning gene expression changes during Drosophila embryogenesis dlvr.it/TVKnWr #biology #science

Chromatin context shapes SPT5 regulation of promoter-proximal Pol II, fine-tuning gene expression...

Using rapid SPT5 depletion, Dulja et al. uncover different molecular phenotypes at different embryonic stages. In early embryos, SPT5 depletion shifts Pol II from the pausing site to the +1 nucleos...

cell.com
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Online now: Natural variation in TOLS1 modulates salt tolerance via OsRacB-Ca2+ signaling pathway in rice dlvr.it/TVDkF5 #biology #science

Natural variation in TOLS1 modulates salt tolerance via OsRacB-Ca2+ signaling pathway in rice

Many salt-tolerance QTLs have been identified in rice, but only a few underlying genes have been cloned and mechanistically characterized. Feng et al. identify TOLS1, a major QTL gene encoding a...

cell.com
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Online now: Senescent cells maintain viability through adhesion-dependent fragmentation that promotes debris deposition dlvr.it/TVDXbc #biology #science

Senescent cells maintain viability through adhesion-dependent fragmentation that promotes debris...

Durik et al. show that senescent cells generate fragments, termed SCAFs, that support survival by shedding damaged intracellular material. SCAF rupture releases DAMPs, amyloid-like proteins, and...

cell.com
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Online now: Functional versatility of synergid cells in plant reproduction dlvr.it/TVD6XH #biology #science
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Online now: Postnatal Pax7-expressing limb cells are multipotent and generate non-myogenic lineages that persist into adulthood dlvr.it/TV6q3s #biology #science
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Online now: Tumors exploit interclonal Hedgehog-Wnt crosstalk to drive tumor-promoting cell competition dlvr.it/TV4HC8 #biology #science

Tumors exploit interclonal Hedgehog-Wnt crosstalk to drive tumor-promoting cell competition

Intratumoral heterogeneity fuels cancer progression through poorly understood cooperative mechanisms. Kong et al. reveal that tumors exploit interclonal Hedgehog-Wnt crosstalk to drive “tumor-promo...

cell.com
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Online now: A VHL-HIF signaling axis orchestrates invariant natural killer T cell development and fate decisions dlvr.it/TV3Qfz #biology #science

A VHL-HIF signaling axis orchestrates invariant natural killer T cell development and fate decisions

Li et al. show that the VHL-HIF axis controls invariant NKT cell development. VHL loss stabilizes HIF1α, which drives iNKT cell apoptosis and blocks iNKT2 fate via mitochondrial metabolism, and...

cell.com
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Online now: Proteasome-dependent protein degradation shapes developmental tempo in mouse and human neural progenitors dlvr.it/TV19fF #biology #science

Proteasome-dependent protein degradation shapes developmental tempo in mouse and human neural...

Why do mammalian species develop at different speeds? Nakanoh, Stamataki, et al. show that mouse neural progenitors have faster protein synthesis and proteasome-mediated degradation than human....

cell.com
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Last chance to register and save for @CellPressEvents #CSCellDeath26 (Oct 22–24, Hangzhou, China)! Join experts, including keynotes Douglas Green (@StJudeResearch) and Hao Wu (@WuLabHarvard), and help shape the future of cell death research. Register: hubs.li/Q04rDRPM0
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Online now: Systematic differences in protein stability underlie species-specific developmental tempo dlvr.it/TV0bk4 #biology #science

Systematic differences in protein stability underlie species-specific developmental tempo

Using dynamic SILAC proteomics, Matsuda et al. show that protein degradation is globally slower in human than in mouse segmentation clock cells. Glycolysis inhibition in mouse partially phenocopies...

cell.com
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Online now: Elongating human heart organoids recapitulate early cardiac morphogenesis and axial organization dlvr.it/TTyr4b #biology #science
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Online now: A thermoregulatory module for timekeeping in Arabidopsis dlvr.it/TTvw1C #biology #science
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Online now: The ARLA1A-NAC089 module coordinates ER phagy with the unfolded protein response to maintain cellular homeostasis in plants dlvr.it/TTs7my #biology #science
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Online now: Nodal/Smad2 signaling sustains developmental pausing by repressing Pparg-mediated lipid metabolism dlvr.it/TTrznY #biology #science
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Online now: Redox signaling in development: An emerging frontier dlvr.it/TTnwQ5 #biology #science
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Online now: Pulmonary cold sensing through Club cells triggers adipose thermogenesis to ameliorate obesity dlvr.it/TTkSrc #biology #science
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Online now: Longitudinal zone- and cell type-specific pattern-triggered immune responses in Arabidopsis roots dlvr.it/TThfdp #biology #science

Longitudinal zone- and cell type-specific pattern-triggered immune responses in Arabidopsis roots

Xu, Ortiz-Morea, and Kim et al. combine single-cell transcriptomics and live-cell imaging to map immune responses across Arabidopsis root cell types and developmental zones to different elicitors....

cell.com
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