DiscoverMedNews@DiscMedNews

News and major stories from evidence-based medical research and published peer-reviewed medical studies.

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Joined March 2023
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This study presented clinical, radiological, and laboratory features of cytotoxic lesions of the corpus callosum (CLOCCs) in COVID-19 patients. The corpus callosum connects the cortical zones of the left and right hemispheres. discovermednews.com/cytotoxi… #brain #COVID19
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Interestingly, some previous papers indicated changes in the domain of brain lateralization in COVID19 and post-COVID patients. The CC is associated with functional cortical lateralization at the level of interhemispheric inhibition but also contributes to brain symmetry.
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Spatial gene expression analysis revealed SARS-CoV-2-related #inflammation in the epipharynx of patients with #longCOVID, suggesting the therapeutic potential of epipharyngeal abrasive therapy. discovermednews.com/epiphary…
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Epipharyngeal lymphoid tissue and palatine tonsils are the main lymphatic organs of Waldeyer’s ring, the innate immune system of the upper respiratory tract.
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Up to 245 days after vaccination, the persistence of vaccine-derived S1 protein in CD16+ #monocytes and an altered cytokine profile were found in SARS-CoV-2-negative individuals with post-COVID-19 #vaccination syndrome. #spike discovermednews.com/the-pers…
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It seems that the persistence of vaccine-derived S1 protein in CD16+ monocytes for months can maintain inflammation and contribute to post-COVID-19 vaccination syndrome in SARS-CoV-2-negative individuals.
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A case series of 30 newly diagnosed or relapsed glomerular diseases after COVID-19 mRNA vaccination. The most common glomerular disease was immunoglobulin A nephropathy (IgAN). discovermednews.com/glomerul… #mRNAvaccine #kidney
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The absolute risk of glomerular disease increased after the second or third vaccination. Although rare, relatively severe diseases, such as PGNMID, TAFRO syndrome, and anti-GBM nephritis, occurred after vaccination.
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#SARSCoV2 spike and nucleocapsid proteins were detected in extracellular vesicles or as free proteins in the bronchoalveolar lavage fluids from post-COVID patients up to two years after acute COVID-19. #lungs discovermednews.com/sars-cov…
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Interestingly, most S and N proteins were contained in the extracellular vesicles in the BAL fluids of patients with post-COVID lung disease. In contrast, most HIV-GP120 proteins were present as free proteins in the BAL fluids from HIV-positive subjects.
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HIV-GP120 protein was also detected in extracellular vesicles or as free proteins in the bronchoalveolar lavage fluids from HIV-positive subjects on HAART therapy with undetectable blood viral load.
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SARS-CoV-2 #spike protein could exacerbate #stroke: In a mouse model of transient focal brain ischemia, the SARS-CoV-2 spike protein increased infarct volume, inflammation, and coagulation and reduced cerebral blood flow. discovermednews.com/sars-cov…
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The RAAS imbalance increased coagulation and decreased fibrinolysis, which worsened ischemic stroke outcomes, as evidenced by increased infarct size, reduced cerebral blood flow, and increased cognitive impairment.
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This study provides new evidence that SARS-CoV-2 S protein injection given to hACE2 KI mice seven days before transient focal brain ischemia disrupted the RAAS balance by increasing Ang II/AT1R signaling in the brain’s cells at the expense of the Ang II/AT2R protective arm.
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#Perimenopause (2 years prior and 2 years after the final menstrual period) is a period of increased risk of first-onset #psychiatric disorders major depressive disorder and mania. discovermednews.com/perimeno…
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Intussusceptive angiogenesis could be the main driver for a specific cardiac injury induced by SARS-CoV-2. #heart #COVID19 #angiogenesis discovermednews.com/intussus…
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Ackermann et al., who examined the lungs of seven people who died from COVID-19, were the first to describe intussusceptive angiogenesis in the pathogenesis of COVID-19.
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The most remarkable finding in the cardiac remodeling triggered by the SARS-CoV-2 was a marked neovascularization in the form of intussusceptive angiogenesis, associated with significant infiltration of CD11b+/TIE2+ macrophages, which are drivers of intussusceptive angiogenesis.
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An in vitro study, which investigated the effect of #macrolides on #bronchial epithelial cells and the integrity of the #respiratory barrier showed that #Azithromycin is superior to other macrolides in improving the respiratory epithelial barrier. discovermednews.com/azithrom…
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#Azithromycin treatment was distinct in terms of enhancement of the epithelial barrier, retention of phospholipids, vesicle build-up, and its effect on gene sets related to keratinocyte differentiation and establishment of the skin barrier.
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