This is the first of multiple manuscripts that use our patented approach to increase protein production in gene specific way from a wild type allele in happloinsufficiencies using antisense oligonucleotides (ASOs). Great collaboration with @MillerLabNeuro and funded by @CZI. Many more manuscripts and ASOs to come in the near future. Protein expression is amplified by stabilizing mRNA using gene-specific antisense oligonucleotides biorxiv.org/content/10.64898…

Sam Snyder from @DjuranovicLab and Hugh Notman from @slavicaPD lab delivered great scientific talks at CSHL Translational Control and Molecular Parasitology meeting in Woods Hole this month. You'll hear more about peptidyl-tRNA drop-off and functional prion like domains soon.

Starting strong with seminars this school year. Today (Sep 8th) we have Hani Zaher from WashU as the Giuliani RNA Center Seminar guest. Tomorrow (Sep 9th) we have Jody Puglisi from Stanford University as the MCBGP speaker and guest. Come and join us.

Another publication from our collaboration in DARPA project is out today in Nature Communications. This study shows that transgenic schistosomes expressing SARS-Cov2-antibody in guts of mice can prevent viral infection of mice. Thanks to all people that contributed to this study. nature.com/articles/s41467-0…

Great news this morning, Amir Orian's lab and @DjuranovicLab received BSF funds for collaborative project on post-transcriptional control of cell identity in the next 4 years. Looking forward to this collaboration and joint project between Technion and Brown University.

NOA for @DjuranovicLab from NIGMS for our R35 application on "Mechanisms of Translational control" is here. Great way to celebrate one year of lab being at @BrownUniversity and Giuliani RNA Center. Thanks to NIGMS and reviewers from last (June '25) and this year (June '26) for providing support to our studies. This is continuation of two of our R01 grants that were in place for 10 and 5 years, respectively.

It is a great privilege to be named Mencoff Family RNA Research Professor of Molecular Biology, Cell Biology and Biochemistry at Brown University. I am grateful to Samuel M Mencoff and Mencoff Family, Brown University, Department of Molecular Biology, Cell Biology, and Biochemistry and Guiliani RNA Center at Brown for this honor. Djuranovic lab will soon celebrate their first year at Brown University.

Fresh out of the press today. Great colaboration with @slavicaPD and @Mak_Mitreva labs as well as multiple other ones involved in this project. nature.com/articles/s41467-0…

10 days of RNA science in Montreal. RNA Society Meeting and Codon Usage Meeting one after other.

Our polyA track and splicing story is out today. More on Zcrb1 and it's role in U12 splicing, cilia, centrosome and l coming soon from Stratman and Djuranovic labs. Loss of U11/U12 spliceosome gene ZCRB1 leads to aberrant ciliogenesis and WNT signaling life-science-alliance.org/co…

Excited to share the first paper from our new lab @UTSWMedCenter @UTSWScience ! 🎉 Now out in @NatureComms Mechanisms of human mitochondrial leaderless mRNA translation initiation nature.com/articles/s41467-0…

4 years after terrible loss (two -80C freezers and back-ups) of almost all of our collection of regular and mutant human, Drosophila, E. Coli and Plasmodium cells, and a big hustle with insurance we are going to publish first manuscript that was hindered by this loss. Additional 2 manuscripts are on the way as well. Lot of repeated experiments, use of additional resources and lot of lost nerves over the last 4 years that could have been avoided. This was a valuable collection of mutant cell lines as well as CRISPR/Cas9 engineered lines with endogenously tagged-RBPs, translation factors, ribosomal proteins and other proteins. More than 50% of engineered Plasmodium cells are still not recovered. My suggestion to everyone is to keep some of your most valuable cell lines and back-ups in your collaborators freezers or at least in different buildings or towns.

Our RAPPL international patent application has just been published. @slavicaPD

Visit from a friend and great colleague from Newcastle University. Sergey Melnikov will after snowy February in Providence talk tomorrow about hibernating ribosomes. Another talk at Brown RNA Center. #ribosomes #RNA