This is big. Ray Kurzweil tracked exponential tech curves for decades and nailed the internet boom plus chess AI early. His 2032 longevity escape velocity prediction matches the AI-biotech surge today. Here is what he actually said: “By around 2032, people who are diligent with their health are going to reach what we call longevity escape velocity. This is when scientific breakthroughs will add more time to our remaining life expectancy than is going by. So we’ll be going backwards in time as far as our health is concerned.” He goes on: “We’ll soon have the ability to rapidly test billions of possible molecular sequences to find cures, ultimately for all diseases.” Kurzweil earned the National Medal of Technology and built AI at Google for over a decade. His track record is public and documented. The original full interview is here: piped.video/watch?v=Ln9-8Xef… If you already follow basics like sleep, zone 2 cardio, resistance training, continuous glucose monitoring, and evidence-based supplements, you are positioned for this window. Next six years of therapies will compound your healthy years faster than aging.

Strength training = nutrition = recovery. You need all these components in balance. If you don't know how to recover in the best way possible, read my article below.

Scientific research on nattokinase shows it is a potent fibrinolytic enzyme derived from fermented soy. Controlled studies report reductions in blood pressure and modulation of coagulation factors in humans. At higher intake levels around 10,800 FU daily, extended use has been associated with reduced carotid plaque thickness and improved lipid profiles in large clinical cohorts, with a favorable safety profile. Lower doses show smaller or inconsistent effects on lipids. Mechanistic data suggest effects on endothelial function and vascular inflammation. Traditional intake from natto in Japan typically provides ~1,000–2,000 FU per serving, alongside vitamin K2 (MK-7), soy isoflavones, probiotics, and fermentation-derived peptides. Supplemental nattokinase isolates the enzyme, usually 2,000 FU daily for general support, with higher doses used in interventional settings under supervision. This raises an important question: are observed cardiovascular benefits in natto-consuming populations attributable to nattokinase alone, or to the broader fermented soy matrix including K2 and isoflavones? Conversely, does isolated supplementation replicate the vascular effects without the additional bioactive compounds? Another layer worth discussing is soy’s isoflavone content. While fermented soy contains phytoestrogens with generally weak and context-dependent activity, concerns about estrogenic signaling persist. Does fermentation meaningfully alter isoflavone bioactivity? And does isolated nattokinase avoid that concern entirely, or remove potentially synergistic compounds? The distinction between whole-food exposure and enzymatic isolation deserves more rigorous comparative trials.

People treat a tin of sardines as a bit suspect. Cheap, canned, oily fish, it sounds like the exact thing to avoid. Almost every reason for that is wrong. Fear one: mercury and heavy metals. Sardines are the answer to this, not the cause of it. Mercury builds up as it climbs the food chain, so the danger sits in the big, old predators. The sardine is tiny, eats plankton, and dies young. It never lives long enough to collect the stuff. A swordfish carries around seventy times more. The sardine is about as clean as fish gets. Fear two: the can leaches metal into the fish. Decades out of date. That fear comes from old lead-soldered tins, phased out long ago. Modern cans are welded and lined, and the fish inside is untouched. Fear three: canned means processed, and processed means bad. Canning is a fish cooked once and sealed away from the air. Nothing is stripped out of it, and the sealing is exactly what keeps the omega-3 intact. It is the opposite of the factory food that word usually describes. Now hold that tin next to the thing people trust instead. The fish oil capsule. That oil is squeezed out, concentrated, heated, bottled, and left on a shelf for a year. A New Zealand study found 92% of capsules oxidised past the limit. A George Washington study found nearly half were rancid, the taste covered by flavouring. The fear was pointed at the wrong shelf. The rancid oil is in the pill. The sardine just sits there, whole and clean, for a pound.

Aspirin remains one of medicine's most fascinating paradoxes. It is lifesaving in secondary prevention after myocardial infarction and ischemic stroke, and remains a cornerstone of acute coronary syndrome management. In primary prevention, however, routine use has largely fallen out of favor because modest cardiovascular benefit is often offset by GI and intracranial bleeding. Patient selection is everything. The oncology story is becoming more compelling. Large cohort studies and recent meta analyses suggest lower colorectal cancer incidence, reduced metastatic spread, and lower cancer mortality, likely through platelet inhibition, COX-1/COX-2 modulation, and improved immune surveillance. The signal is strongest for colorectal cancer, but causality for routine prevention remains unproven. (ScienceDirect) For athletes, the evidence is surprisingly reassuring. There is no convincing human evidence that low dose aspirin (75 to 100 mg/day) reduces muscle hypertrophy, strength, or recovery. Concerns about impaired adaptation originate mainly from higher dose NSAIDs, not cardioprotective aspirin doses. Bleeding risk, however, may become more relevant in contact sports and endurance events. (JAMA Network) The real question is no longer "Is aspirin good or bad?" but can biomarkers identify those who gain meaningful anticancer and cardiovascular benefit while avoiding unnecessary bleeding? Sources: NEJM, JAMA, JAMA Oncology, Journal of the American College of Cardiology (JACC), Public Health (2025 meta-analysis), USPSTF Evidence Review.

Most people think you need long runs to build endurance. The data say otherwise. Repeated sprint training can increase VO₂max by 5 to 15% in just 2 to 8 weeks, with 80 to 90% less training time than traditional endurance programs. Mechanisms: • ↑ PGC-1α → more mitochondria • ↑ AMPK → greater oxidative capacity • Growth hormone peaks up to ~10× baseline after maximal sprint sessions • Greater fast-twitch fiber recruitment Long Zone 2 runs still win for: • Fat oxidation • Stroke volume • Capillary density • Running economy The evidence isn't "sprints vs long runs." It's when to use each. 📚 Gibala et al. (2012) pubmed.ncbi.nlm.nih.gov/2220… 📚 Milanović et al. (2015) pubmed.ncbi.nlm.nih.gov/2542… 📚 MacInnis & Gibala (2017) pubmed.ncbi.nlm.nih.gov/2770… Which session do you actually look forward to more? A quiet 10 km in Zone 2, or 8 all-out sprints that leave your legs shaking?