#2025pacesetter Only in pediatrics! Cecilia Gonzalez Corcia and Georgia Sarquella Brugada refuse to debate at their debate. Instead they constructed a collaborative high-impact presentation on sodium channel blocker challenge for Brugada syndrome
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Are they suggesting that an asymptomatic relative with normal EKG of a gene-negative proband with BrS ELK should undergo drug infusion testing?
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If I understand your question correctly, they lean in favor after shared decision making. This is from the new EHRA/HRS guideline academic.oup.com/europace/ar…
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1/ The key and fundamental issue is the overly permissive definition of "spontaneous type 1 pattern" as BrS. In the 2013 consensus statement (Priori), asymptomatic patients with spontaneous type 1 pattern required additional supportive features:
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Replying to @jeffrey_vinocur
2/ As we ((nature.com/articles/s41598-0…) and others have shown, the prevalence of type 1 Brugada pattern is highly underestimated, and accordingly the risk associated with isolated type 1 is likely overestimated.

Apr 27, 2025 · 6:15 AM UTC

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Replying to @jeffrey_vinocur
3/ therefore the unequivocal recommendation for performing drug challenge test (SCB), a highly nonspecific test, in asymptomatic RELATIVES of asymptomatic isolated type 1 probands - is not clear to me. @MJAckermanMDPhD
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Ohhh I have not dug through the guideline in detail yet honestly. But I think your objection is not so much about the relatives but rather about whether BrS should be diagnosed in the proband in these situations (with type 1 ECG but nothing else)
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