Designing Reactions for Applications in Biology
Newark, DE
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Congratulations to @Taylorlab_Chem and @kuehl_nicholas on another spectatular paper.
Our radical photocage work is out in @JACS! The photocage directly releases free CF3 radicals and enables MS-mapping of proteins w/ 1s rxns and prep-scale peptide trifluoromethylation in minutes. Impressive solo student author effort by @kuehl_nicholas! pubs.acs.org/doi/10.1021/jac…
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Fox Lab at UD retweeted
Our radical photocage work is out in @JACS! The photocage directly releases free CF3 radicals and enables MS-mapping of proteins w/ 1s rxns and prep-scale peptide trifluoromethylation in minutes. Impressive solo student author effort by @kuehl_nicholas! pubs.acs.org/doi/10.1021/jac…
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Fox Lab at UD retweeted
Check out our preprint in @ChemRxiv where we develop a photocage for biomolecular trifluoromethylation. Protein-interaction mapping w/ 1 second rxn times and prep scale labelling in 5-7 minutes. Impressive solo researcher effort by @kuehl_nicholas! chemrxiv.org/engage/chemrxiv…
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Fox Lab at UD retweeted
Awesome day yesterday with @aroralabnyu visiting! Great talk by and discussions with Bobby, as always. We made sure to give Bobby some local history at the Deer Park at the end of the day. In the Poe raven shadow. Quoth the @FoxGroupUD @CLGrimesLab nevermore!
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Thiomethyltetrazines are reversible covalent cysteine warheads whose reversibility can be "switched off” via live cell bioorthogonal chem, providing stability to lysis/proteomics. Led by @TallonAmanda w/ @Pfizer Mary Xu, Graham West & @ChrisamEnde1 10.26434/chemrxiv-2023-w0p5m
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Congratulations to Dr. Andrew "AJ" Jemas, most recent Ph.D. from the Fox group! You can check out one of his papers here: a collaboration with Pfizer to photocatalytically turn-on tetrazine ligation with subcellular precision. doi.org/10.1021/jacs.1c10390. So proud of you AJ.
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Fox Lab at UD retweeted
Congratulations to #UDel's Laure Kayser, who has won an @NSF CAREER award, supporting her research on a new class of #polymers using innovative chemistry and materials science approaches. ow.ly/QyX750Na9Up @UDengineering @udcas #bioelectronics
ALT A portrait of Assistant Professor Laure Keyser of the University of Delaware, who has won a National Science Foundation CAREER Award for her innovative research on a new class of polymers, which may be useful in bioelectronics.
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Out in @J_A_C_S! Ligand-directed catalysts for live-cell, photocatalytic activation of dihydrotetrazines coupled to new uncaging chemistry. Congratulations to Jules @RosenbergerJE, Yixin, Fang, Xinyi, Will and Olga! Thanks for support from NIGMS and
@Pfizer #PfizerChemistry
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Great to see this out in press. Congratulations Sam and Tyler!
Affinity Bioorthogonal Chemistry (ABC) Tags for Site-Selective Conjugation, On-Resin Protein-Protein Coupling, and Purification of Protein Conjugates (Fox) @FoxGroupUD onlinelibrary.wiley.com/doi/…
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Still excited about bioorthogonal chemistry? Check out this preprint describing ligand-directed catalysts for live-cell, photocatalytic activation of dihydrotetrazine oxidation and uncaging chemistry. Kudos @RosenbergerJE, Yixin, Fang, Xinyi and Will! chemrxiv.org/engage/chemrxiv…
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Joining the chorus of congratulations to this amazing trio and their research groups. Special shout out to @CarolynBertozzi and her alums who are blazing so many new trails that connect chemistry with biology and medicine.
BREAKING NEWS:
The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”
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Congratulations to Julia Rosenberger @RosenbergerJE as one of the poster winners at the International Society of Heterocyclic Chemistry meeting. Thank you to @ishc1967, @thevanderwallab, and Javier and Yang at UCSB for leading a terrific meeting! Our group had a terrific time!
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Fox Lab at UD retweeted
Thanks @Biochem_Chem for the warm welcome! Very excited to be here @uarizona!
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Congratulations to an amazing colleague and scientist!
As the @ACS_CARB Immediate Past Chair, I am happy to announce that Catherine Grimes @CLGrimesLab is a recipient of The 2023 Horace S. Isbell Award given for Excellence in and promise of continued quality of contribution to research in carbohydrate chemistry.
ALT Congratulations to all #ACSCARB Award recipients! I look forward to celebrating their #glycotime success at the Spring 2023 ACS National Meeting in Indianapolis.
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Fox Lab at UD retweeted
We're moving! Very excited to announce that we will be joining @Biochem_Chem at the University of Arizona later this month! Grateful for our time at Wyoming but looking forward to all the new directions and discoveries to be made @uarizona!
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Congrats to Dr. Sam Scinto (blue shirt) on his Ph.D. defense. Sam's been a scientific trailblazer in our group, and an amazing grad mentor to students in our group and across our department. Congratulations and best of luck in your postdoc work in the scholar program at Pfizer!
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Fox Lab at UD retweeted
The first generations of biochemist in @FoxGroupUD ! Congrats on your defense Sam!!
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Affinity Bioorthogonal Chemistry tags (ABC-tags) enable both protein purification and fast bioorthogonal chemistry. Succeeds at C- or N-terminus, internal positions, and can be carried out on-resin to generate multidomain proteins. Congrats Sam & Tyler! doi.org/10.26434/chemrxiv-20…
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Check out this deep-dive into understanding the factors that influence tetrazine stability and D-A reactivity-- and how to increase the latter without compromising the former. Congrats to @MikulaLab, @Click_Chemist, and the Houk group.
Uncovering the Key Role of Distortion in Bioorthogonal Tetrazine Tools That Defy the Reactivity/Stability Trade-Off @tu_wien @Click_Chemist @houk1000 @uclachem @tuvienna @MikulaLab #Click #Bioorthogonal #Tetrazine pubs.acs.org/doi/10.1021/jac…
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