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Frontiers | Challenges and dilemmas of exercise therapy in the management of osteoporosis: a...

Osteoporosis is a chronic, progressive bone condition that impacts over 200 million people globally, with fragility fractures significantly burdening healthc...

Frontiers | Efficacy and safety of ultrasound-guided microwave “Near-Total Ablation” for refractory...

ObjectiveThe current study aims to investigate the efficacy and safety of ultrasound-guided microwave “Near-Total Ablation” in the treatment of refractory hy...

Frontiers | Prediction of gross extrathyroidal extension in papillary thyroid carcinoma using a...

BackgroundGross extrathyroidal extension (ETE) affects surgical management and prognosis in papillary thyroid carcinoma (PTC), yet noninvasive assessment is ...

Frontiers | Corneal endothelial changes in type 2 diabetes mellitus: a systematic review and...

BackgroundType 2 diabetes mellitus (T2DM) affects multiple ocular structures, yet the extent of corneal endothelial alterations across different stages of di...

Frontiers | Commentary: Pembrolizumab-induced type-1 diabetes mellitus: clinical characteristics,...

Guo et al. provide an important characterization of pembrolizumab-induced T1DM based on 43 published cases.(1) Diabetic ketoacidosis occurred in 36 patients ...

Frontiers | The CKM–GDM multi-organ precision model: reframing gestational diabetes as an early...

BackgroundGestational diabetes mellitus (GDM) is amongst the commonest complications of pregnancy and an early marker of lifetime cardiovascular–kidney–metab...

Frontiers | CFTR variant-associated hereditary pancreatitis complicated by diabetes mellitus: a...

Hereditary pancreatitis (HP) is a rare autosomal dominant disorder characterized by recurrent episodes of pancreatic inflammation leading to chronic pancreat...

Frontiers | Investigating the effect of diet-induced prediabetes on the HPA-axis, sympathetic...

BackgroundPrediabetes is associated with metabolic dysfunction that may disrupt neuroendocrine regulation before the onset of overt type 2 diabetes mellitus....

Frontiers | CT-based age-related trabecular redistribution in the proximal femur and its associat...

Proximal femoral fractures are the most common fall-related fractures in the elderly. In our clinical work, we observed a phenomenon of trabecular redistribu...

Frontiers | Reproductive outcomes after expectant management and 5- versus 15-minute laparoscopic...

BackgroundLaparoscopic ethanol sclerotherapy is a fertility-preserving alternative for ovarian endometriomas, but the appropriate ethanol exposure duration r...

Frontiers | Simultaneous semen and urine biomonitoring of neonicotinoids and associations with...

BackgroundNeonicotinoid insecticides (NEOs) are among the most widely used insecticides worldwide, yet their presence in seminal plasma and potential implica...

Frontiers | Seminal dysbiosis in idiopathic male infertility: toward a seminal dysbiosis–inflamma...

Idiopathic male infertility (IMI) usually refers to abnormal semen parameters after known causes have been excluded. However, its clinical stratification and...

Frontiers | The role of LLPS of biomacromolecules in the gonads and related diseases

Liquid–liquid phase separation (LLPS), an emerging mechanism of intracellular organization and regulation, has attracted increasing attention in reproductive...

Frontiers | Management of pregnancy in patients with Graves’ disease secondary to alemtuzumab: a...

IntroductionAlemtuzumab treatment for multiple sclerosis frequently induces Graves’ disease (GD), characterized by common coexistence of stimulating and bloc...

Frontiers | Anatomical location matters: risk modelling and surgical outcomes in central lymph node...

BackgroundIsthmus papillary thyroid carcinoma (iPTC) represents a distinct clinical entity with a higher propensity for central lymph node metastasis (CLNM) ...

Frontiers | When diabetic ketoacidosis becomes a neurological emergency: cerebral edema in a child...

BackgroundDiabetic ketoacidosis (DKA) is a life-threatening complication of type 1 diabetes mellitus (T1D), potentially leading to severe outcomes, including...

Frontiers | CD98hc marks a precursor of human stem cell-derived alpha cells primed for functional...

IntroductionPluripotent stem cell-derived alpha cells (SC-α cells) represent a promising component of next-generation cell therapies designed to more fully r...

Frontiers | Efficacy of an Eastern Healthy Dietary Pattern-modified ketogenic diet in patients with...

ObjectiveTo evaluate the efficacy and safety of an Eastern Healthy Dietary Pattern (EHDP)-modified ketogenic diet in Chinese patients with obesity and polyen...

Frontiers | Pain as a predictor of incident frailty in middle-aged and older adults with metabolic...

BackgroundMetabolic dysfunction-associated steatotic liver disease (MASLD), defined here by the lipid accumulation product (LAP), is common in middle-aged an...

Frontiers | Continuous glucose monitoring after discontinuation of incretin-based obesity pharmac...

Discontinuation of incretin-based pharmacotherapy is frequent and is associated with weight regain and metabolic relapse, including deterioration in cardiome...