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Frontiers | From chromatin to proteostasis: multilevel gene regulation in Mendelian diseases

Pathogenic variation can alter gene output at multiple levels, from chromatin accessibility and enhancer-promoter communication to RNA processing, translatio...

Frontiers | Epigenetic, chromatin-associated, and epitranscriptomic regulation in chronic pain:...

Chronic pain is sustained by durable yet dynamic changes in gene regulation across sensory neurons, spinal circuits, glial and immune cells, and higher brain...

Frontiers | singIST: an R/bioconductor library and quarto dashboard for automated single-cell...

BackgroundPreclinical disease models frequently fail to recapitulate human pathophysiology at single-cell resolution, complicating model selection and limiti...

Frontiers | Case Report: Co-occurrence of Wilson disease and tuberous sclerosis complex in a...

BackgroundWilson disease (WD) and tuberous sclerosis complex (TSC) are rare genetic disorders with distinct pathophysiologies. Their co-occurrence has not be...

Frontiers | A novel frameshift RPL15 gene variant associated with hydrops fetalis and perinatal...

BackgroundThe heterozygous RPL15 gene (OMIM*604174) variants are associated with autosomal dominant Diamond-Blackfan anemia 12 (DBA12, OMIM#615550). Fewer th...

Frontiers | Bridging bone and muscle: ontology-driven prioritization of candidate genes at the...

IntroductionOsteosarcopenia reflects the co-occurrence of osteoporosis and sarcopenia, but the molecular processes shared between impaired bone and muscle ho...

Frontiers | Artificial intelligence for precision gene therapy: emerging technologies, clinical...

Artificial Intelligence (AI) is revolutionizing gene therapy from an empirical and iterative process to a predictive, data-driven and increasingly intelligen...

Frontiers | A novel homozygous DLGAP5 splice-site variant in a woman with oocyte maturation arrest...

Oocyte maturation arrest (OMA) is a rare cause of female infertility characterized by impaired oocyte maturation and recurrent failure of assisted reproducti...

Frontiers | AI Agents and Agentic AI in plant breeding: new frontiers, opportunities and challenges

Plant breeding increasingly integrates diverse data sources, including genomic, phenomic, and environmental information, yet current artificial intelligence ...

Frontiers | Cord blood-based neonatal genetic screening for thalassemia in Guiyang, China (2015): a...

BackgroundThis study aims to assess the carrier frequency and molecular spectrum of thalassemia in neonates from Guiyang, China, a multi-ethnic region with h...

Frontiers | Modified Bixuesan modulates inflammatory and apoptotic gene expression in post-radiot...

BackgroundPost-radiotherapy chronic pharyngitis affects 60%–80% of laryngeal cancer survivors and is characterized by sustained elevation of pro-inflammatory...

Frontiers | Correction: A workshop considering genetic research and data collection with American...

Correction on: Beans JA, Blanchard JW, Hiratsuka VY, Helton T, Carroll SR, Dillard DA, Orr R, Gachupin FC, Hull SC, Haring RC, Garrison NA, Saunkeah B, Tsosi...

Frontiers | Combined RNA- and DNA-targeting CRISPR ribonucleoproteins enhance suppression of HBV...

IntroductionChronic hepatitis B virus (HBV) infection remains a major global health problem and there is no curative treatment currently available. RNA-targe...

Frontiers | Benchmarking hyperparameter optimization strategies for crop genomic prediction

Genomic prediction has become an important approach for accelerating crop breeding by using genome-wide marker information to predict complex traits. However...

Frontiers | Integrated analysis of autophagy and ferroptosis mediating aristolochic acid A-induced...

IntroductionAristolochic acid A possesses anti-inflammatory, antispasmodic and diuretic pharmacological activities, while exerting strong toxic effects that ...

Frontiers | Metabolic programs associated with GDSC2-inferred oxaliplatin sensitivity are favorably...

BackgroundOxaliplatin is widely used in gastric cancer (GC), yet molecular features associated with sensitivity are heterogeneous and incompletely defined. P...

Frontiers | FANCD2 knockdown suppresses malignant phenotypes and is associated with caspase/PARP-...

BackgroundMalignant pleural mesothelioma (PM) is a highly aggressive thoracic malignancy with an extremely poor prognosis and limited effective therapeutic s...

Frontiers | Engineering TnpB as a compact RNA-guided genome editor from molecular constraints to...

Recent discoveries of non-CRISPR RNA-guided nucleases have expanded the landscape of programmable genome editing beyond canonical Cas systems. Among these, T...

Frontiers | Correction: Editorial: Cancer cell metabolism and tumor microenvironment remodel