What does an AI-native workflow for protein binder design look like in practice? In our latest post, we walk through a pilot design run using NovaDDE: Given a target, the AI agent analyzes the design problem, helps select an epitope and design approach, submits the job, and guides the computational evaluation of the resulting candidates. We also share some of the directions we’re exploring as we continue to develop the workflow. A closer look at NovaDDE and where we’re taking it next: geodesiclab.com/news/novadde…

Today, we’re launching the Geodesic API Platform. geodesiclab.com/api For the first time, Geodesic is making our AI models and drug discovery capabilities available through APIs. At its core is NovaAtom, our in-house model for predicting the structures of proteins, small molecules, nucleic acids, and their interactions. Now available in Lite Preview, this is the first time NovaAtom has been made available beyond Geodesic’s own discovery platform. Alongside NovaAtom, we’ve integrated the field’s core models — carefully curated and continuously updated. To use the API: curl -X POST platform.geodesiclab.com/api… \ -H "Authorization: Bearer $GEODESIC_API_KEY" \ -F "model=novaatom" \ -F 'params={"jobName":"rbd-nanobody","sequences":">rbd\nTNLCPFGEVFNATRFASV...\n>nb\nQVQLVESGGGLVQAGGSLR..."}' Poll the job, pull the results, and feed them directly into the next model. Your AI assistant can use the platform directly, too. Connect Claude Code, Codex, or your own agent with one URL and an API key. We manage the integrations and handoffs. You focus on the science. Understand biology. Predict structures. Design proteins. Discover molecules. One key. One interface. Start building today!

NovaDDE Plus is now live! Built for scientists who use AI for drug discovery every day — more compute, priority access, concurrent runs, API access, and end-to-end campaign execution. $30/month and sign up by September 25 to get your first month free. Our goal is simple: put the most powerful AI for drug discovery into the hands of every scientist. geodesiclab.com/pricing

We’re launching the Geodesic Grand Challenges. What are the hardest questions in drug discovery that, if solved, could change what’s possible over the next 5–10 years? We’re asking you to help define them. Selected questions will become official Geodesic Grand Challenges. Each selected contributor receives 10,000 Geodesic credits. Once the challenges are selected, we’ll open a call for solutions, with a $1 million prize for a verified solution to each challenge. The next breakthrough starts with the right question. Submit yours！ geodesiclab.com/grand-challe…