The Gilbert Lab@GilbertLabRNA

We love RNA

Joined September 2018
55 Photos and videos
We are so excited to share our latest work profiling dihydrouridines across the yeast transcriptome! 🎉🎉 Led by grad student extraordinaire @a_draycott, this was a wonderful collaboration with fellow C-wing RNA enthusiasts @LeoSchaerf and @NeugebauerKarla journals.plos.org/plosbiolog…

Transcriptome-wide mapping reveals a diverse dihydrouridine landscape including mRNA

This study presents dihydrouridine sequencing (D-seq) for transcriptome-wide mapping of this RNA modification with single-nucleotide resolution, revealing dihydrouridine at new locations across the...

journals.plos.org
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Congratulations to our rock star grad students Cassandra and @Cole_JT_Lewis who both won poster awards at #RNA22! 🎉🎉🎉

ALT Congrats gif with Michael Scott and Erin spraying champagne in celebration

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Gilbert labbies past and present! So wonderful to see everyone again. Now we’re just waiting on the dancing 💃🏻 🕺🏻 #RNA2022 #RNA22
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The Gilbert Lab retweeted
PLOS Biology@PLOSBiology
25 May 2022
Novel method (D-seq) for transcriptome-wide high-res mapping of dihydrouridine reveals this #RNAmodification at new locations across the yeast transcriptome, suggesting broad role in folding functional RNA structures @a_draycott @GilbertLabRNA #PLOSBiology plos.io/3wR5Mta
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Congratulations @roniederer!! We can’t wait to see what cool new discoveries you make about translational control! 🎉
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In a span of < 1 wk, @GilbertLabRNA publishes 2 incredible @ACS_Research stories-1st w insights into how mRNAs are born, tumors & mets; & then @AmericanCancer PF @roniederer publishes cell.com/cell-systems/fullte… showing how these mRNA instructions are used, & how to manipulate them🤯

Direct analysis of ribosome targeting illuminates thousand-fold regulation of translation initiation

Niederer et al. develop a method to quantify translation initiation on thousands of 5′ UTRs in parallel. They uncover sequence-specific motifs that control translation by varied mechanisms and...

cell.com
The Gilbert Lab@GilbertLabRNA
21 Jan 2022
More good news! 🎉 Here we uncover roles for pseudouridylation and pseudouridine syntheses in alternative mRNA processing. Spearheaded by the fantastic @nicolemmart, this was a collaborative effort with @yeo_lab Congratulations to all authors! sciencedirect.com/science/ar…
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More good news! 🎉 Here we uncover roles for pseudouridylation and pseudouridine syntheses in alternative mRNA processing. Spearheaded by the fantastic @nicolemmart, this was a collaborative effort with @yeo_lab Congratulations to all authors! sciencedirect.com/science/ar…
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Check out the latest work from our lab! Congratulations to @roniederer @bzinsh and @mfrd18! 🎉🎉🎉 authors.elsevier.com/c/1eR4-…
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The Gilbert Lab retweeted
Nicole M Martinez@nicolemmart
19 Nov 2021
Excited that the Martinez Lab @StanfordMed @ChemSysBio @Stanford_ChEMH @DevBioStanford is hiring! We are looking for a Research Assistant to work on projects related to how RNA modifications and mRNA processing control gene expression. Apply - job ad here: careersearch.stanford.edu/jo…
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Huge congratulations to @Cole_JT_Lewis for getting the NOA on his F31 this week!!! #sweet16 🎊🍾🎉🎊🍾🎉
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Oh hey we know that paper 😄
Ribosome Papers@ribosome_papers
17 Jul 2021
bioRxiv: Cellular translational enhancer elements that recruit eukaryotic initiation factor 3 dlvr.it/S3x43V
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We are delighted to share our latest work on translational control elements that bind eIF3! biorxiv.org/content/10.1101/…

Cellular translational enhancer elements that recruit eukaryotic initiation factor 3

Translation initiation is a highly regulated process which broadly affects eukaryotic gene expression. Eukaryotic initiation factor 3 (eIF3) is a central player in canonical and alternative pathways...

biorxiv.org
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We had a great time welcoming Shivani Bhandarkar to @GilbertLabRNA with a feast!
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Huge congratulations to @nicolemmart who is starting her own lab @Stanford! Keep an eye out for exciting work on #RNA processing and modifications!
Nicole M Martinez@nicolemmart
1 Jul 2021
I am delighted to announce that the Martinez Lab is starting in January 2022 @ChemSysBio @DevBioStanford @Stanford_ChEMH! I am so grateful to my amazing mentors @WendyGScientist and Kristen W Lynch and to @GilbertLabRNA for their unconditional support.
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Starting very soon!
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The Gilbert Lab retweeted
Junjie Guo 郭俊傑@guo_lab
14 Jun 2021
It's out! Dr. Yu Sun in the lab identified merafloxacin as a pan-betacoronavirus programmed -1 ribosomal frameshift inhibitor. Great collaboration with @BrettLindenbach @WendyGScientist @roniederer @WilenLab @HoLabHIV and YCMD colleagues @YaleWestCampus pnas.org/content/118/26/e202…

Restriction of SARS-CoV-2 replication by targeting programmed −1 ribosomal frameshifting | PNAS

Translation of open reading frame 1b (ORF1b) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires a programmed −1 ribosomal fra...

pnas.org
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Great science with great people!
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Don’t miss @roniederer sharing her work identifying novel translational control elements during the mechanisms and regulation of translation session this morning at #RNA2021!
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