The CDC raised its benchmark for levels of the Covid virus in wastewater, adjusting a key metric for assessing the disease’s transmission. As a result, officials may now classify a level that once counted as high transmission as moderate instead. nbcnews.com/data-graphics/cd…

Wow! multiple sclerosis is caused by viral reactivation in monocytes and B cells months before clinical onset. nature.com/articles/s41591-0…

"the SARS-CoV-2 accessory protein ORF3a binds to the endoplasmic reticulum (ER) chloride channel CLCC1, thereby impairing ER ion homeostasis, activating the unfolded protein response, and inducing endomembrane remodeling.. during early infection, ORF3a accumulates in the ER, co-assembles with CLCC1 into puncta, and disrupts ER homeostasis; at the later stage, ORF3a overload enables its escape from CLCC1-mediated ER retention and subsequent translocation to lysosomes, facilitating viral egress. This ER-centric function is conserved across diverse beta-coronaviruses, including SARS-CoV-1 and bat- or pangolin-derived strains, revealing a unified pathogenic strategy. Furthermore, in mouse brains, the ORF3a-CLCC1 axis recapitulates key neuropathological features, including ER stress, autophagic dysfunction, neuronal death, and neuroinflammation, providing a mechanistic link to COVID-19-associated neurological symptoms." So, what's our strategy? 'The accessory protein ORF3a hijacks the CLCC1 chloride channel to disrupt ER homeostasis in betacoronavirus pathogenesis' nature.com/articles/s41421-0…

Why Do My Tweets Get Less Impressions as My Followers Grow? circleboom.com/blog/why-do-m…

A possible biological fingerprint for #LongCOVID brain fog ➡️ A fascinating new PET-imaging study found significantly reduced VMAT2—a marker of dopamine nerve terminals—in the brains of people with LongCOVID. ➡️ The reduction was 16–20% in key regions involved in motivation, movement and memory, and the degree of abnormality closely tracked specific symptoms. 1/

13 new PJ.2.1 sequence were just uploaded from the US, 10 from California and three from Colorado, so that makes a total of 21 new PJ.2.1 sequences on the day.

Studie: Viele Viren, mit denen man sich als Kind bereits infiziert hatte, schlummern danach lebenslang verborgen und inaktiv im Körper. Dann kam COVID. Covid infiziert nicht nur, sondern weckt auch genau diese Viren wieder auf, die jahrzehntelang auf diesen "Weckruf" gewartet haben. Eine neue, in Nature veröffentlichte Studie hat nun genau identifiziert, um welche Viren es sich dabei handelt.

Wird ein wohl stürmischer Herbst mit Überflutungen bei uns werden.

Das war in meiner Jugendzeit noch ein Sommer-Schigebiet in den italienischen Bergen, wo man ganzjährig Wintersport betreiben konnte.

In den letzten 100 Jahren gab es bisher nur drei Mal Temperaturen von mehr als 32 Grad im September in Ostösterreich: 1942, 2015 und heute. Das ist 2026 definitiv kein "normaler Sommer". Ich fürchte, das Schlimmste steht uns in den nächsten Wochen noch bevor, und das wird nicht die Hitze sein.

The neurologist in the room is telling you that the scientific literature is extremely clear on the neurological impacts of SARS-CoV-2 COVID is neurotropic and continues to infect. Loss of grey matter & damage to the cerebral cortex are well documented. This IS the COVID effect

🔴A few weeks ago I shared a thread about a question that keeps coming back across more than a century of medicine: Why do some people never fully recover after an infection? I’ve now turned that thread into a much more detailed Substack article, with more examples, more historical context and more references. From the Russian flu and the 1918 influenza pandemic to H1N1, post-polio syndrome, EBV, Q fever, Giardia, SARS, MERS, Ebola and Long COVID, the same pattern appears again and again: very different infections can leave a subset of people with persistent, multisystem illness. The article also goes deeper into what could connect these conditions, including tissue damage, pathogen or antigen persistence, immune dysregulation, autoimmunity, HLA and host susceptibility. Long COVID may be new in scale, but post-infectious illness is not. I’ve expanded the original thread here: manruipa.substack.com/p/long…

Breaking: New PolyBio-Supported Study Finds Overlapping Persistent Virus-Specific T cell Responses in Long COVID The research provides new evidence that Long COVID is characterized by ongoing immune responses to persistent viral proteins, further supporting the role of viral persistence and herpesvirus reactivation in the disease process. 1/

A deep analysis of what may have lead to the Nepal glacial collapse and a breakdown of how the flood overtook communities in a matter if minutes. #Nepal #flood #weather

Cremona 😳😳😳

⛈️Foto di Fausto Capelli, per Emilia Romagna Meteo, della grandine di grosse dimensioni caduta oggi pomeriggio a Sperongia di Morfasso (PC).

❗️Numerosi danni segnalati nel Mantovano, in particolare a Goito, Porto mantovano e San Giorgio Bigarello, a causa del passaggio della supercella temporalesca. Video di Stazione meteo Suzzara da Porto Mantovano e di Laura Benedetto da San Giorgio Bigarello.

Ein ganz normaler Sommer heute wieder in Frankreich ...

Paris heute. Ein ganz normaler Sommertag ....

I cambiamenti climatici non esistono… Nei secoli dei secoli amen. #climateChange