Curiosity. Human Model Systems. EvoDevo. CompBio. Translation. Institute of Human Biology. Basel. graycamplab@bsky.social

What makes our cells human? The evolution of human development is undeniably fascinating. It is an exciting time to explore the details! We, @brainevodevo, @craiglowe, @KlkUmut, @NatureRevGenet review and suggest new inroads: rdcu.be/c4Pno #sapiens #evodevo #organoids
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Your new batch of cortical organoids resulted in mixed regional identities closer to hindbrain. Why is patterning so hard?😩 ✨Our latest paper might help you✨ tinyurl.com/neorgpat #morphogen #neuralorganoids #patterning #scRNAseq @TreutleinLab @GrayCampLab @ETH_en
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A great opportunity for candidates that want to build and lead a unit for scientific software engineering for #AI in an academic context: Head of the #AI Core Unit of Munich's new cluster of excellence #BiosysteM for #BiosystemsDesign - for details, visit: portal.mytum.de/jobs/wissens…
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Systematic scRNA-seq screens profile neural organoid response to morphogens. @TreutleinLab @ETH_BSSE @naturemethods nature.com/articles/s41592-0…
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PDAC is a terrible malady and needs new inroads. We integrate a cell atlas, develop 3D tumoroid models, and map phenotypic spaces at scale. Very cool data inside! @IHB biorxiv.org/content/10.1101/…, biorxiv.org/content/10.1101/…
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I was at the @FCBasel1893 vs. Lugano game tonight and managed a great video of the follow-up from the superb penalty save...looks like a goal to me?! I didn't see a better perspective on highlights (@SRF?), so sharing it here! Hope it gets to the fans! 😀⚽️
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Here is a still from the video, what do you think? 🔍
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3 consecutive frames...
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We are searching for computational PhDs and Postdocs to join our group in collaboration with @TreutleinLab . We have exciting single-cell technology projects that incorporate bioengineering, computation, biology, translation. Send CV to deco_ihb@roche.com
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Human-mouse cross-species comparison identifies common and unique aspects of intestinal mesenchyme development biorxiv.org/content/10.1101/… A companion piece to our recent work from my colleague Kate Walton, led by Kelli Johnson and Xiangning Dong!
Excited to share our latest preprint led by Kelli Johnson- Mapping mesenchymal diversity in the developing human intestine and organoids! We defined 5 mesenchymal populations occupying discrete anatomical locations within the human intestine. biorxiv.org/content/10.1101/…
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We made the cover! 🎉 Our vascular organoid paper is featured on the August issue of @CellStemCell Stem Cell. Huge shoutout to Liyan Gong for dreaming up the cover concept. Always exciting to see our science come to life visually. cell.com/cell-stem-cell/full…
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Director at Max Planck - a unique position! The Open Call for Expressions of Interest in Max Planck Directorships is open now and can be submitted by the 31st of October 2025. ➡️mpg.de/directors - Please share the Open Call among potential candidates.
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Excited to share our latest preprint led by Kelli Johnson- Mapping mesenchymal diversity in the developing human intestine and organoids! We defined 5 mesenchymal populations occupying discrete anatomical locations within the human intestine. biorxiv.org/content/10.1101/…
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We are happy to announce an opening for a Tenure Track Assistant Professor Faculty Position in Neuroscience at EPFL. Join our groups working on cellular & circuit neuroscience & neurocomputation - go.epfl.ch/brain. Deadline Oct 1 2025, Apply now - go.epfl.ch/neurofaculty
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Diet/microbes place the gut epithelium as a nexus for evolutionary change. With @TheSpenceLab @genomeCraig, we use #organoids to explore how evolution prepared the developing human intestine for exposure to the environment. @ScienceMagazine #evodevo 🧵1/11 science.org/doi/10.1126/scie…
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We identify and functionally evaluate 2 human accelerated regions (HARs) at the IGFBP2 locus. Provocatively, these data indicate that the IGF pathway contributed to evolutionary change in the developing human intestine, potentially augmenting small intestine length. 10/11
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Altogether, we identify the developing human intestinal epithelium as a rapidly evolving system, and show that great ape #organoids provide insight into human biology. 🙏Thanks to all authors/reviewers! Especially co-first authors: @CY_Qianhui_YU @KlkUmut @stefanosecchia 11/11
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