Assistant professor @ UMN. My lab studies how myelin regulates the function and health of neurons. Father and husband who loves the outdoors.
Minneapolis, MN
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nature.com/articles/s41467-0…
I am excited to announce our work on how myelin loss culminates in neurodegeneration has been published at Nature Communications. While I have previously covered our findings as a preprint in more detail below, our key findings are:
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Greg Duncan retweeted
New work from Yasmine Kamen shows that differentiating oligodendrocytes are filled with the zymogen procaspase-3. This provides a specific marker for new oligodendrocytes and suggests a role for this pathway in oligodendrocyte fate decisions.
biorxiv.org/content/10.1101/…
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nature.com/articles/s41467-0…
I am excited to announce our work on how myelin loss culminates in neurodegeneration has been published at Nature Communications. While I have previously covered our findings as a preprint in more detail below, our key findings are:
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Our work was recently covered by the National MS Society if you are looking for a more lay summary of the results and its implications.
nationalmssociety.org/news-a…
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Greg Duncan retweeted
And the completion of this story was only possible because of all the help from the most amazing @Anya_A_Kim and Björn Neumann in the Franklin lab!🥰
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3. Remyelination suppresses activation of DLK in neurons and safeguards them from degeneration.
In conclusion, demyelinated neurons can be protected either by promoting remyelination or blocking neuronal DLK signaling.
Thanks to all the coauthors who made this work possible!
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1. Loss of demyelinated neurons in the retina requires activation of neuronal injury signaling mediated by the axonally-expressed protein Dual Leucine zipper Kinase (DLK).
2. DLK knockout or inhibitors protect neurons from degeneration.
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Very excited to share our preprint on how chronic myelin loss (demyelination) injures neurons and how we may be able to mitigate neurodegeneration in demyelinating diseases like MS
biorxiv.org/content/10.1101/…
Check out the thread 👇 for more details.
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What does all this mean? We can protect demyelinated neurons from loss in two ways – by promoting remyelination or by inhibiting DLK. Notably, even a relatively small degree of remyelination reduces apoptosis.
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Greg Duncan retweeted
Why is age the main risk for Alzheimer’s disease? Mouse models reveal that the loss of myelin integrity is causally linked to enhanced plaque deposition. Great work by @ConstanzeDepp, @TingSun_MPINAT et al. in Nature nature.com/articles/s41586-0…
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Excited to see our preview of the great work from Su et al. published in Neuron on how astrocyte endfeet regulate myelination. Their work gives an excellent insight into how astroycte-oligo interactions shape myelination.
cell.com/neuron/fulltext/S08…
cell.com/neuron/fulltext/S08…
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