More fluorophore options, more ways to build your HCR™ Gold assay. HCR™ Gold Amplifiers are now available with 488, 546, 594, and 647 labels across every X system, giving you more flexibility when designing panels around your targets and imaging channels. Ready to explore the new options? Shop the expanded amplifier selection today. 🛒 store.molecularinstruments.c…

Yesterday, we hosted a webinar on “Multimodal alignments of in vivo imaging and spatial biology datasets at cellular resolution.” A special thank-you to our wonderful speakers, @jxqjim and @LunWangm from @Stanford, for sharing how TRU-FACT integrates #HCRtechnology with functional imaging and connectivity data to link cellular activity, molecular identity, and projection targets. We enjoyed this installment of HCR™ webinars and look forward to sharing more soon!

We’re heading to the @NS4Histotech Convention this weekend! Come say hello at Booth #620 to connect with our team and join us for our workshop, “Translating Spatial RNA Biomarkers into Point-of-Care Lateral Flow Assays,” where we’ll highlight how #HCRtechnology can be adapted for lateral flow detection. 🗓️ Sept. 29 🕤 9:15–10:15 AM

We're excited to introduce Slide Wash Chambers for manual slide-based workflows! Orders that include HCR™ Wash Buffers for tissue sections or cells on a slide will now receive two complimentary Slide Wash Chambers. Each chamber provides a lower-volume alternative to traditional Coplin jar setups, helping reduce wash buffer use during manual assays. Add HCR™ Wash Buffers to your next order to receive yours: molecularinstruments.com/sho…

What a fantastic time at the German Fish Meeting! It’s always exciting to see #HCRtechnology used in such a wide range of model systems. This week, it was especially fun to hear about so many fish models, including zebrafish, cavefish, and more. Thank you to everyone who stopped by to share how you’re using HCR™ workflows in your research. We loved hearing about the variety of applications across the fish model community. Next up for the MI team: @NS4Histotech Convention!

San Antonio, we’ll see you soon! The MI team will be at the National Society for Histotechnology Convention. Stop by Booth #620 to talk about HCR™ workflows, RNA and protein imaging, and how our team can support your research goals. Don’t miss our workshop, “Translating Spatial RNA Biomarkers into Point-of-Care Lateral Flow Assays,” for a practical look at adapting #HCRimaging for lateral flow detection. 🗓️ Tuesday, September 29 🕤 9:15–10:15 AM See you there!

More fluorophore flexibility for HCR™ Gold is here! HCR™ Gold Amplifiers with 488, 546, 594, and 647 labels are now available for every X system, giving you more flexibility to configure assays around your specific target panel and imaging setup. All new catalog amplifiers are available to order on our webstore. Order here: store.molecularinstruments.c…

What can you learn when cellular activity, molecular identity, and projection targets are connected in the same cells? Join @LunWangm and @jxqjim from @Stanford on Wednesday (Sept 23) at 10:00 am PT for a closer look at TRU-FACT, an experimental and computational pipeline for registering individual cells across in vivo imaging and molecular profiling datasets. Register here: my.demio.com/ref/qB2R1mep0on…

More automation options for HCR™ Gold IF! We’re thrilled to share that HCR™ Gold IF is now available on the Biocare Medical ONCORE Pro X staining platform. Powered by the HCR™ HiFi Encoder, HCR™ Gold IF helps researchers build multiplex immunofluorescence assays with off-the-shelf primary antibodies, including same-species combinations, without custom conjugation, stripping, or fixed antibody panels. The workflow also supports species-on-species staining, including mouse-on-mouse and human-on-human assays. Read the full announcement: businesswire.com/news/home/2… Interested in getting started? Contact us at info@molecularinstruments.com.

Don’t miss our upcoming webinar featuring @LunWangm and @jxqjim from @Stanford! Discover how TRU-FACT registers individual cells across in vivo imaging and molecular profiling datasets, connecting cellular activity, molecular identity, and projection targets at cellular resolution. 🗓️ Wednesday, September 23 🕤 10:00 AM PT Learn how #HCRtechnology helps enable the molecular profiling behind these multimodal alignments. Register here: my.demio.com/ref/qB2R1mep0on…

Next stop: the 1st German Fish Meeting! From zebrafish to cavefish, #HCRtechnology enables sensitive, multiplexed RNA and protein imaging across diverse fish models, helping researchers visualize gene expression with high-resolution across samples and developmental stages. Join us on Wednesday (Sept. 16) for our workshop featuring an overview of the platform, deeper dives into HCR™ Gold RNA-FISH and HCR™ Gold IF, and office hours for live experiment planning. Session 1: 9:00 AM Session 2: 10:45 AM 📍Center for Organismal Studies, University of Heidelberg 🗓️ September 16 - 18, 2026

Spotlighted by the @InfoIzfs: Dr. Elliot Perens (@UCSanDiego, @radychildrens) used HCR™ imaging to capture the posterior lateral mesoderm in zebrafish. 🟠 gata1a 🟢 etv2 🔵 hand2 🟣 hnf1ba Check out the IZFS feature here: izfs.org/news/new-izfs-websi…

Build HCR™ Gold IF Around More Primary Antibodies More antibody panels can now be configured for HCR™ Gold IF! With Rabbit IgG and Mouse IgG1 Encoders now available across X1-X10, plus new Mouse IgG2a and Human IgG options, you now have more flexibility to design sensitive, multiplexed protein imaging experiments around the antibodies and channels that best fit your research workflow. Whether you’re building a same-species panel or expanding into higher-plex protein imaging, these additions make it easier to design around the antibodies and channels your experiment requires. Configure your manual HCR™ Gold IF assay here: lnkd.in/gyxQvTPA Interested in automated HCR™ Gold IF workflows? Contact your MI representative or email info@molecularinstruments.com, and our team can help you get started.

Up next: Santa Cruz Developmental Biology Meeting We're excited to head to Santa Cruz to connect with researchers working across developmental systems, stages, and sample types. If HCR™ workflows are already part of your research or if you’re thinking about RNA and protein imaging for a new project, come say hello. We’d love to hear what you’re working on. 📅 August 24–28 We hope to see you there!

Meet the MI team at the 2026 Summer Conference on Neural Circuits in Health and Disease! Megan Le and Kelly Lee are looking forward to connecting with the neuroscience community and learning more about the research questions driving the field. Find them at the event to talk about #HCRtechnology for sensitive, multiplexed RNA and protein imaging in neuroscience research.

Image RNA, protein, or both with HCR™ Gold. HCR™ Gold supports sensitive, multiplexed fluorescent imaging with enhanced signal-to-background across RNA and protein targets. With HCR™ Gold, researchers can: • Image RNA targets with HCR™ Gold RNA-FISH • Image protein targets with HCR™ Gold IF • Co-detect RNA and protein in the same sample • Image up to 10 RNA and/or protein targets without repeated staining cycles Explore HCR™ Gold: HCR™ Gold RNA-FISH: molecularinstruments.com/hcr… HCR™ Gold IF: molecularinstruments.com/hcr…

Deciding between HCR™ Gold and HCR™ Pro? Choose the amplification system that fits your target, readout, and experimental context. HCR™ Gold supports quantitative, multiplexed fluorescent imaging of up to 10 RNA and/or protein targets with simultaneous, enzyme-free amplification and built-in background suppression across a broad range of samples. HCR™ Pro enables ultra-sensitive, protease-free RNA and protein detection with fluorescent or chromogenic readouts, making it well suited for low-abundance targets, autofluorescent samples, and experiments where signal-to-background is at a premium. Both are built on the same HCR™ HiFi foundation, giving researchers flexibility to choose the workflow that best fits their application. Explore HCR™ Gold and HCR™ Pro: molecularinstruments.com/sho…

Looking for a protein imaging workflow that fits your research needs? HCR™ Gold IF supports sensitive, multiplexed protein detection across manual and automated workflows, so researchers can choose the setup that best fits their sample, platform, and throughput needs. Configure your manual HCR™ Gold IF kit: store.molecularinstruments.c… Interested in automated workflows? Contact us at info@molecularinstruments.com

Thank you to everyone who spent time with us at the 85th SDB Annual Meeting! It was a pleasure hearing about the developmental systems, sample types, and stages you’re working with, and talking through how #HCRtechnology can support your research. A special thank-you to our colleagues from @LeicaBio for joining us and helping answer questions about bringing HCR™ assays onto the automated BOND RX research stainer. If we missed you at SDB, reach out to us at info@molecularinstruments.com. We’d be happy to connect!

Are you heading to the SDB Annual Meeting? This year, we’ll be joined by our colleagues from @LeicaBio to talk about bringing familiar HCR™ assays onto the automated BOND RX research stainer for less hands-on staining and a faster path from signal to interpretation. Come stop by Booth #5 to connect with the MI and LBS teams! 📅 July 23–26 📍 Booth #5