HND_Lab@HND_Lab

Henderson Neurodegenerative Disease Lab. Misfolded proteins, disease processes, therapeutic development. PD and AD pathogenesis 🔬🧠

 Grand Rapids, MI
hendersonlab.vai.org/
Joined October 2019
57 Photos and videos
We are kicking off a new initiative this month: Lab Member Spotlight. We will be highlighting a different member each month to showcase our talented team in the Henderson Lab! Our first featured lab member is Kevin Kurgat! Thank you for all of your hard work, Kevin!
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We had an exciting week welcoming our new graduate student, Laura, to the lab!
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Come help us unravel the mysteries of neurodegenerative diseases!
Michael Henderson@MXHend
May 12
We’re hiring a Postdoc in the Henderson Lab @ Van Andel Institute! Join our team studying neurodegenerative disease across scales (molecular → circuits). Flexible, high-impact projects and strong mentorship. Apply: vai.wd1.myworkdayjobs.com/en… Please share!
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Congratulations to @_AnikaWeekes on passing her comprehensive exam! Looking forward to all the exciting research to come!
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Another fantastic year of hard work and discoveries in the lab! Happy holidays and new year from the Henderson Lab!
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Congratulations to MD/PhD student Noah Lubben on passing his comprehensive exam!
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Congratulations to Dr. Goralski on a fantastic dissertation defense! The whole lab showed up in Tommy's usual attire to celebrate with him! #PhD
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Excited to celebrate the graduation of our first PhD student--Dr. Alysa Kasen! @AlysaKasen
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Had another great summer party! Celebrating 5 years!
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Congratulations to graduate student, Alysa Kasen, for successfully defending her dissertation!
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It’s been a busy year so far in the Henderson lab! We have several new lab members to welcome—Anika and Noah as new graduate students, Aastha as a new postdoc, Sydney as a new technician, and Giang, Kelsey, and @Abbeyzuzelski who are joining us as summer fellows! Lab is bustling!
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Henderson Lab winter party 2024! Happy holidays everyone!
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We then used these data to gain cellular insight by inhibiting 12 kinases associated with vulnerability. Among these, inhibition of group II PAKs was highly neuroprotective in a neuron model of α-synucleinopathy. Bridge from pathology patterns to molecular targets complete!
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Bridging network and cellular biology took a large team including co-first authors @namanvatsa, Kate Brynildsen, Tommy Goralski, and Kevin Kurgat and long-time collaborator @DaniSBassett!
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Can new targets for Parkinson’s disease be identified by examining pathology patterns in the brain? We are very excited to share our latest preprint where we explore exactly that question. biorxiv.org/content/10.1101/…

Network analysis of α-synuclein pathology progression reveals p21-activated kinases as regulators...

α-Synuclein misfolding and progressive accumulation drives a pathogenic process in Parkinson’s disease. To understand cellular and network vulnerability to α-synuclein pathology, we developed a...

biorxiv.org
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We developed a brain-wide neuron gene expression atlas (PANGEA). The atlas can be browsed here: lume.tv/PANGEA/. Surprisingly, resilience is associated with mitochondrial pathways!
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We then compared these pathology patterns to the brain’s connectome, predicting where pathology would go. Some regions should have developed pathology but did not. What underlies this resilience?
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We first needed data on the longitudinal progression of α-synuclein pathology. We captured this in over 1000 brain regions and 8 timepoints in a murine model.
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Happy to welcome @_AnikaWeekes to the lab for a rotation!
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Great Grand Challenges in Parkinson’s Disease conference @VAInstitute! @Alysa_Kasen_ and Tommy Goralski took home poster prizes. #proudpi
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