The most promising longevity drug isn't a peptide or metformin. It's the Shingles vaccine. New data shows it slows biological aging and lowers systemic inflammation for 4+ years post-shot. We are seeing a 20% reduction in new dementia diagnoses and a 25% lower risk of stroke. Stop waiting for a magic pill. One is already on the shelf.

The vial says “not for human consumption”. People are injecting it anyway. “Research use only” does not prove what is inside or that it is sterile. With Dr. Mayoni Gooneratne and CareCore.

Peptide FOMO is ahead of what I’m seeing in practice. Beyond GLP-1s, I see more hype than substance around many popular peptides. I’ll discuss the cautions with patients. That isn’t proof of the promise. With Dr. Mayoni Gooneratne. Hillary Lin, MD · CareCore

Your genetic heart-risk score may fit its training data better than it fits you. Many scores rely heavily on European-ancestry data. Ask how well yours was validated in people like you. piped.video/watch?v=SG1aq_6v…

A DEXA visceral-fat estimate doesn’t measure fat inside your liver. MRI-PDFF measures liver fat. Scarring is a separate question. Before buying a scan, ask what the result would change. Save the test guide. pmc.ncbi.nlm.nih.gov/article…

ApoB, Lp(a), fasting insulin: different clues, not a single longevity score. The question is what you'd change because of the result. From my conversation with Zach Morris on Wealth Beyond Work.

1% for longevity. Kyle Gonzalez's way of making exercise feel less daunting: think about the small share of your week it takes, then get specific about strength, cardio and recovery. From The Longevity Show.

Longevity has become big business. But is it becoming real medicine? Join us for the next NYC Health Innovaition Night on Wed. Oct. 14 featuring Guest of Honor @HillaryLinMD, host of the Longevity Show. Co-Hosted with @MedStartr's @alexbfair. Register now: eventbrite.com/e/new-york-he…

Should you test your biological age? Before you pay: how repeatable is the result, and what does a “younger” score actually prove? I'll discuss this at MVMNT, Sept 22–23 in Coronado. JOINME10: 10% off registration. theemvmnt.com/

A 2% health risk means 2 in 100 people. If you’re one of them, you don’t experience 2% of the consequences. The percentage describes a population. You live with the outcome. My conversation with Wei-Wu He: piped.video/watch?v=SG1aq_6v…

No lab. No wearable. Just a hill. Find the steepest one near you and walk it briskly. "As fast as you can" might be very slow — fine. The question isn't today's effort. It's whether the same hill gets easier. Not right for everyone; ask your clinician first. piped.video/watch?v=KahsHPVz… @BrooksLeitner @VO_Health

A health tracker inside your bra sounds ridiculous. But it sits right above the heart, which makes sense. The heart data from @PetalToday interests me. Its visceral-fat estimate? Show me the MRI/CT validation. Women’s health needs more weird hardware. petal.today/products/petal

Let's talk FIBERMAXXING. I am glad fiber is having its moment. There are much worse nutrition trends. But fiber may be the most misunderstood line on a nutrition label, because we treat it as one thing. This denies fiber's true powers. Psyllium forms a gel, holds water, and can lower LDL. Oat beta-glucan changes post-meal glucose and insulin only when it retains enough viscosity. Different resistant starches push gut microbes toward different metabolites. Bran adds bulk, which can help some people and make others feel worse. Even the familiar 25 g/day target is a public-health guide, not a deficiency cutoff or proof that 45 g is better for you. The long-term evidence is strongest for fiber-rich food patterns. The randomized evidence is strongest for specific fibers doing specific jobs. So no, fibermaxxing is not bad. But chasing the gram score is not the same as using fiber well. Before adding another scoop, ask: 1. What result do I want? 2. Which fiber can help? 3. What dose can I tolerate? 4. Am I eating more plants, or only gaming a label? Do not just maxx. Match the fiber to the job. I turned the deeper clinical read into a full guide, with the constipation decision rules, oatmeal breakdown, two-week experiment, safety notes, and source list: hillarylinmd.com/guides/fibe… The next Longevity Letter goes deeper on why I stopped chasing the fiber score. Subscribe from the guide before this weekend's note goes out.

VO₂ max is powerful. It is not the whole game. It measures cardiorespiratory fitness — not strength, not grip. Both matter for staying capable as you age. One excellent number isn't a complete plan. Train your engine. Keep your muscle. piped.video/watch?v=KahsHPVz… @BrooksLeitner @VO_Health

"CrossFit gave me a pretty good VO₂ max, but I have no aerobic base." That's my guest — on his own training. Peak capacity and sustained easy output are related, not identical. He didn't quit CrossFit. He added longer rows and bike work. "Fit" isn't one thing. piped.video/watch?v=KahsHPVz… @VO_Health @BrooksLeitner

"Zone 2" is not one universal number. Multiple zone systems exist, anchored to different thresholds and measured in different ways. Zone 2 isn't useless. It just isn't standardized. Before you chase it: which system? based on what test? piped.video/watch?v=KahsHPVz… @VO_Health @BrooksLeitner

Have you seen the stairs in those Italian cities? A documentary was baffled that Italian nuns live so long — all that bread, all that wine. Maybe the Blue Zones "secret" is movement nobody has to call exercise. Debated, not proven. piped.video/watch?v=KahsHPVz… @BrooksLeitner @VO_Health

I used to think posting online would cost me my integrity as a doctor. What I feared was becoming salesy. Sunita Mohanty and I are talking about how clinicians can show up without turning medicine into marketing. Wed, noon ET: streamyard.com/watch/F7aZh83…