ALT The Historic Original Inner Beauty Hot Sauce Recipe (courtesy Chris Schlesinger, East Coast Grill) 5 lb scotch bonnet or habanero peppers 1 gallon yellow mustard 1/2 lb brown sugar 1 quart orange juice 1/2 gallon white vinegar 1 cup honey 1 cup molasses 46 oz. papaya juice 46 oz. pineapple juice 1/2 gallon peanut oil 6 oz. each of cumin, chili, curry, tumeric 2 oz. all spice salt and pepper

ALT Arc of history

ALT America is an idea Harris ahirt

ALT Abolishing the NIH would not create a funding vacuum. The private sector funds 78 percent of U.S. biomedical research and development. Venture capital has exploded. Investment focused on artificial intelligence in drug discovery alone surged nearly 36-fold between 2010 and 2024 - funding the overwhelming majority of innovative medical devices and building the AI revolution in biomedicine. The Howard Hughes Medical Institute, the Wellcome Trust, the Gates Foundation and the Chan Zuckerhero Initiative renresent

ALT (Evan Vucci/AP) By Scott Atlas Scott Atlas is the Robert Wesson senior fellow in scientific philosophy and public policy at the Hoover Institution and was special adviser to President Donald Trump in fall 2020.

ALT Histed and Aviles SSRN working paper

ALT Clown shoes pro-oligarchy pablum, supported by far-right billionaires — a Hoover fellow, brought in by Trump 1 to blame others for COVID, arranged doubt via billionaire-funded AIER, and now writes in the Bezos Post.

ALT green pool. credit Jamie Dupree

ALT ACKNOWLEDGEMENT OF CONDITIONS OF CONTINUED EMPLOYMENT FO EMPLOYEE MOVED TO SCHEDULE POLICY/CAREER This letter serves as notice that I received information concerning the requirements for continued employment as follows: Agency Name: Position Title: Pay Plan-Series-Grade: . I understand I will serve in an excepted service, Schedule Policy/Career position beginning June 3, 2026. I understand that movement into Schedule Policy/Career will result in me occupying an excepted service position. I understand that my service in this position will be at-will. I understand that my position does not confer appeal rights to the Merit System Protections Board (MSPB) concerning performance, discipline, or any other matter arising under chapters 23, 43, and 75 of title 5, United States Code. I understand that prohibitions on prohibited personnel practices will be enforced by the Office of General Counsel [or agency equivalent position] and not the Office of Special Counsel. I understand that the above

ALT ARTICLE | EDITOR'S COMMENTARY Pharma CEO silence is complicity in the destruction of U.S. science Why leaders of the U.S.’s biggest drug companies should use their influence to stop a ruinous proposal

ALT signal detection theory lecture notes

ALT Jay Van Bavel, PhD @jayvanbavel.bsky.social Large teams develop and small teams disrupt science and technology An analysis of +65 million papers, patents & software products finds that small teams tend to disrupt science & technology with new ideas, whereas larger teams have tended to develop existing ones www.nature.com/articles/s41... Articles b Patents Software 100 132 Disruption percentile 80 29 60 26 Citations 40 23 Disruption percentile 120 80 г 76 16 72- 112 Citations 68 8 14 Disruption percentile 50 35 -5 Citations 가 20L 64 2 J20 20l 4 6 Team size 8 2 4 Team size 8 2 4 6 Team size 8 d f 2.01 - Top 5% disruption - Top 5% citations 2.01 3 - Disruption = 1 - Top 5% citations Relative ratio 1.5 1.0 0.5 - Top 5% disruption - Top 5% citations 을하 20.5 Relative ratio 2 1 0 2 4 6 Team size 0 8 2 4 6 Team size 8 2 4 6 Team size 8 12:18 PM • Apr 21, 2026 Everybody can reply

ALT roon @tszzl the private sector has been remaking its own versions of NIH, ARPA etc as these public science institutions have seen structural decline and defunding and it will be supercharged by the funding NPV of machine intelligence and its firepower at allocation decisions

ALT Letter to Brendan Carr at the FCC

ALT I-ready is bad for learning and worse for enthusiasm for learning

ALT How to vet a tool

ALT Summary The org-mode mailing list has discussed this repeatedly over the past decade+. The pattern is always the same: Someone asks "how do I get Apple Notes-style sync for org-mode?" Responses offer file-level sync workarounds (Dropbox, Syncthing, git) Someone mentions CRDTs or OT as the "real" solution An ambitious project gets started (Rudel, colorg, collab-mode) The project stalls because the problem is genuinely hard Thread dies, question gets asked again 1-2 years later The 2024 thread is the most recent instance of this cycle. No solution has emerged.

ALT Blue Flame Award The blue flame is a symbol used on our website to designate plasmids that have been requested more than 100 times. The Blue Flame Award, first distributed in 2016, serves to congratulate researchers who have at least one plasmid deposited at Addgene that has been distributed more than 100 times. The list below denotes the depositing labs who have the most highly requested plasmids. Currently, there are more than 950 depositors worldwide who have one or more blue flame plasmids. Interested in depositing with Addgene? Learn more about our Plasmid Deposit Process.

ALT Hyperventilation, which points in the direction of increasing power for AI people (the authors may well actually believe it.)

ALT Activity - Mom commented: Please repost this with better audio. 11 hrs ago

ALT amendments thereto—a power which, more than any othe ought to produce universal alarm, because it is levell against the right of freely examining public characters and measures, and of tree communication among the people? thereon, which has ever been justly deemed the only effec tual guardian of every other right. John Adams had expressed virtually the same idea thi three years earlier in his treatise "A Dissertation on the Canon and Feudal Law." He wrote: "Liberty cannot be pro served without a general knowledge among the people, who have a right... and a desire to know; but besides this, ther have a right, an indisputable, unalienable, indefeasible, divine right to that most dreaded and envied kind of knowledge, I mean of the characters and conduct of their rulers.") Madison's phrase "the right of freely examining pubic characters and measures" really expresses the premise of the American political system: the Madisonian premise, we may call it.

ALT Computational Neuroscience Meeting 2025, Florence, Italy Tutorial on training recurrent spiking neural networks to generate experimentally recorded neural activities Tutorial schedule Date: July 5th, 2025 Speakers: Christopher Kim (Howard University) and Remy Yovanno (NIMH/NIH) 13:00 - 14:30. Session 1: Part 1 on rate-based networks and Part 2 on generic spiking neural networks 14:30 - 15:00. Coffee break 15:00 - 16:00. Session 2: Part 3 on balanced spiking neural networks Overview Recent advances in machine learning methods make it possible to train recurrent neural networks (RNNs) to perform highly complex and sophisticated tasks. One of the tasks, particularly interesting to neuroscientists, is to generate experimentally recorded neural activities in recurrent neural networks and study the dynamics of trained networks to investigate the underlying neural mechanism.

ALT Steve Rosenberg

ALT Natalie Phelps, stage IV cancer ostient

ALT this note in the Claude's Character essay: Finally, because language models acquire biases and opinions throughout training — both intentionally and inadvertently—if we train them to say they have no opinions on political matters or values questions only when asked about them explicitly, we're training them to imply they are more objective and unbiased than they are. We want people to know that they're interacting with a language model and not a person. But we also want them to know they're interacting with an imperfect entity with its own biases and with a disposition towards some opinions more than others. Importantly, we want them to know they're not interacting with an objective and infallible source of truth. Anthropic's argument here is that giving people the impression that a model is unbiased and objective is itself harmful, because those things are not true! Next we get into areas relevant to the increasingly common use of LLMs as a personal therapist: Claude provides emotiona

ALT Capitol Grocer Aisles of Abundance

ALT A large building with blooming cherry blossom trees in front

ALT A squinting person in front of blooming cherry trees

ALT XI. Whither the engram? Active filtering is one form of engram, a kind of memory Active filtering is a predictive process. In active filtering, the way patterns of input are modified depends on learning. This learning may arise from nature or nurture or both: learning from past experience, or learning encoded in genetically-specified circuit structure acquired over evolution. Because active filtering amplifies patterns of input associated with natural sensory input, which patterns are amplified, and which are not, says something about the natural world. This means that active filtering can also be seen as a form of memory. The recurrent network of the cortex learns about the statistics of the natural world (Berkes et al. 2011, Deveau et al. 2024). It uses that information to amplify a subset of input patterns. The amplification process encodes information about the past — that is, the identity of the amplified patterns is stored in the network as a memory. The memory aspect of active f

ALT Active filtering: a predictive function of recurrent circuits of sensory cortex Mark H. Histed1, ∗ 1NIMH Intramural Program, National Institutes of Health, Bethesda MD 20892† (Dated: January 22, 2025: Preprint) Our brains encode many features of the sensory world into memories: we can sing along with songs we have heard before, interpret spoken and written language composed of words we have learned, and recognize faces and objects. Where are these memories stored? Each area of the cerebral cortex has a huge number of local, recurrent, excitatory–excitatory synapses, as many as 500 million per cubic millimeter. Here I review evidence that cortical recurrent connectivity in sensory cortex is a substrate for sensory memories. Evidence suggests that the local recurrent network encodes the structure of natural sensory input, and that it does so via active filtering, transforming network inputs to boost or select those associated with natural sensation. This is a form of predictive processin