Insco Lab@InscoLab

Account managed by the lab of Dr. Megan Insco

 Dana-Farber Cancer Institute
inscolab.dana-farber.org/
Joined April 2022
23 Photos and videos
🎉 Huge congratulations to Kaiwen for receiving a National Cancer Center Postdoctoral Award! 🏆Your hard work and dedication are truly inspiring. Excited to see all the amazing research ahead! 👏 #ScienceExcellence #CancerResearch #Postdoc
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Thrilled to share the first publication from @InscoLab in @NatureComms! nature.com/articles/s41467-0…
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Motivated by caring for patients with mucosal melanoma (MM), we built the first animal model of this lethal disease and revealed that the cell of origin explains MM’s metastatic and immune-evasive nature.
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Thanks to all for making this possible! @Swathy_BNK #JChen #CBaron #KSun @EmRobitschek #AMcConnell @wustance @dedeilia @sadefeld @RodsyM97 #MManos #KYChen #AMCox @calvin__ludwig @manoliskellis @bbuchbinderMD #NHacohen @yangjiekun @gmboland @TheAbraLab @dliu_ccb @leonard_zon
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Thrilled to share our first independent manuscript! We reveal that recurrent mutations in ZC3H18 stabilize endogenous retroviral RNA, which contributes directly to oncogenesis. Thanks to @BoutzLab, @burns_lab, @NCIChanock, @kbrowngenetics and the rest of our co-authors!
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biorxiv.org/content/10.1101/…

Recurrent oncogenic ZC3H18 mutations stabilize endogenous retroviral RNA

Endogenous retroviral (ERV) RNA is highly expressed in cancer, although the molecular causes and consequences remain unknown. We found that ZC3H18 (Z18), a component of multiple nuclear RNA surveil...

biorxiv.org
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Welcome to Allison Williams!! Allison is a new post doc in the lab who LOVES all things RNA (especially structure), so we greeted her with a zebrafish comprised of RNA structures😁
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The 2024 Insco Lab Retreat was super fun and scientifically illuminating!
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Congratulations to @danafarber researchers Erin Parry, MD, PhD (@ErinMParry), Lachelle Weeks, MD, PhD (@Lachelle_Dawn), and Megan Insco, MD, PhD, who were awarded the Damon Runyon Clinical Investigator Award. Read more ms.spr.ly/6013ll1QP
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Ice cream outing to celebrate Scout's first and Anna's last week😀
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Hobby/craft party to celebrate Anna's success with her PhD applications!
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So excited to welcome Kaiwen Sun as a postdoc in the Insco Lab!
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2nd Annual Insco Lab Retreat in NH!
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Insco Lab summer picnic!
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I am running the B.A.A. Half Marathon this year as part of Team @DanaFarber! My goal is to raise $500-$1000 for the Jimmy Fund, a charity that provides funds towards cancer patient care and research. Please donate if able, or share the link, thank you! danafarber.jimmyfund.org/sit…
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A huge welcome to our new Insco Lab members! Christina helping in the fish room, Gautier here for the summer, and Priyanka a new computational post doc!
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Congratulations to Tanzina for receiving a NCC 2023 fellowship!
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A new cancer mechanism — inability to degrade defective RNAs — appears to cut across many different malignancies and could present a whole new set of cancer targets. Kudos @InscoLab & @leonard_zon. Learn more 👇 #CDK13 #ZC3H14 ms.spr.ly/6011gpiWH

A new cancer mechanism: Buildup of defective RNAs - Boston Children's Answers

Groundbreaking work finds that mutations in CDK13 and other genes that help cells dispose of defective RNAs can lead to cancer.

answers.childrenshospital.org
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Insco Lab retweeted
Cancer Discovery@CD_AACR
5 May 2023
Read this week's #ResearchWatch: Mutant CDK13 Triggers Oncogenic RNA Processing Defects in #Melanoma, a summary of the paper by @InscoLab, @leonard_zon et al. bit.ly/42tlitv @BostonChildrens @DanaFarber
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Check out our Harvard Gazette article! news.harvard.edu/gazette/sto…

Researchers discover how mutant protein leads to melanoma

Discovery of new mechanism could have wide implications for other cancers.

news.harvard.edu
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