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Can 3-dimensional total-body photography improve #melanoma detection? In a randomized clinical trial, this approach led to more #skinlesions being biopsied but did not result in more melanomas detected.
馃搶 Read the article to learn more: ja.ma/4xJCSJ1
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This consensus statement describes the development of multidisciplinary consensus recommendations on the use of staging and surveillance imaging of localized cutaneous squamous cell carcinoma. ja.ma/4ym9d9h
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Elephantiasic #PretibialMyxedema can present with marked lower-extremity swelling, nodular hyperplasia, and toe clubbing in patients with Graves disease.
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For approved #HidradenitisSuppurativa #Biologics, adalimumab showed the most favorable cost-efficiency profile across the US, Canada, France, Germany, and Australia in this economic evaluation. ja.ma/3Vn8kza
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For #PseudofolliculitisBarbae, expert consensus supports behavioral modification of hair removal practices as first-line therapy, with topical, systemic, and laser-based treatment options also recommended.
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馃挰 Editorial: Permanent hair removal may be medically necessary gender-affirming care for transgender women and nonbinary individuals assigned male at birth when #Hirsutism contributes to gender dysphoria, misgendering, and reduced quality of life.
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In advanced #UrothelialCarcinoma, enfortumab vedotin鈥搃nduced cutaneous adverse events were independently associated with improved progression-free and overall survival, especially when skin reactions occurred within 15 days of treatment. ja.ma/4hA9rEl
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Among adults with cutaneous #LichenPlanus, ruxolitinib cream reduced lesions and itch vs vehicle cream and no serious treatment-emergent adverse events were observed.
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ALT JAMA Dermatology RCT summary: Ruxolitinib cream demonstrates 50% IGA-TS at week 16 compared to 21.9% for vehicle cream in 64 patients with cutaneous lichen planus. A bar chart shows Ruxolitinib consistently outperforming vehicle over 16 weeks.
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In a qualitative study of transgender women and nonbinary adults assigned male at birth, #Hirsutism was associated with stigma, social and romantic isolation, and gender dysphoria, and many participants described extensive efforts to conceal visible hair.
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ALT Table 3 lists main themes & representative quotes on hirsutism experiences, covering transphobia, urgency to remove hair, romantic rejection fears, extensive hair removal work, internalized stigma, & sources of support.
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Worldwide, 23% of Stevens-Johnson syndrome and toxic epidermal necrolysis cases are linked to antiepileptic drug use, with nearly all involving aromatic AEDs鈥攃arbamazepine, phenytoin, and lamotrigine as leading contributors. ja.ma/4rn54zP
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In 2024, 35.6% of US women and 26.6% of men engaged in intentional outdoor tanning, with highest rates among young adults, non-Hispanic White individuals, and those reporting heavy drinking or high physical activity. #SkinCancer ja.ma/4yMp3u2
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JAMA Dermatology retweeted
馃摙 Share your opinion: New JAMA+ Trials Poll!
How many clinical trials that claim to be "pragmatic" actually provide useful evidence for real-world decision-making?
馃搳 Vote now and join the discussion: ja.ma/4h5U1rm
#ClinicalTrials #Research #Evidence
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#Tuberculosis risk in dermatologic patients on systemic therapy varied by drug class and region, with higher rates for TNF inhibitors and conventional immunosuppressants, especially in high-burden settings. ja.ma/3T6rHM3
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In a multicenter retrospective cohort, high-dose oral vitamin D was associated with rapid improvement in chemotherapy- and radiation-related skin toxicities without treatment-related adverse events. ja.ma/3UKrP4D
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Circulating tumor DNA testing outperformed erkel cell polyomavirus antibody testing for detecting Merkel Cell Carcinoma recurrence, offering higher predictive accuracy and broader applicability across patient groups. ja.ma/3SIRLwU
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This case report describes 2 patients with discoid lupus erythematosus鈥揳ssociated cicatricial alopecia who underwent follicular unit extraction hair transplant. ja.ma/4xXYMJy
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A RCT found that daily moisturizer use beginning before age 9 weeks may prevent the development of atopic dermatitis in children. JAMA Dermatology EIC Kanade Shinkai, MD, PhD, chose this trial the Editor鈥檚 Choice for Clinical Trial of 2025. ja.ma/4qYKbLh
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In eruptive disseminated #SpitzNevi, multiple mutually exclusive HRAS hot-spot somatic variations were identified across lesions from a single patient, indicating origin from multiple progenitor populations. ja.ma/4AlKAvx
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A woman in her 50s with type 2 diabetes presented with hyperpigmented plaques on her abdomen. Physical examination revealed symmetric, hyperkeratotic, verrucous plaques with thick, brownish, firmly adhered crusts. What is your diagnosis? ja.ma/4xVovC6
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Among pediatric patients with moderate to severe #AtopicDermatitis, #Dupilumab showed long-term effectiveness and safety in a clinical setting, with most patients maintaining controlled disease during 3 years of follow-up. ja.ma/4cG5U4I
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