Assistant Professor at CCHMC. #obesity #metabolism #brownfat #adipocyte. Tweets and opinions are those of JSG and do not reflect my employer's.
Cincinnati, OH
Based in United States
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We are recruiting a motivated Postdoctoral Fellow @CincyChildrens to lead a project on mitochondrial metabolism in thermogenic adipocytes with strong intersections with cardiovascular biology and whole-body metabolism. Come join us! cincinnatichildrens.wd5.mywo…
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I am delighted to share that our paper about the widely used UCP1-CreEvdr transgene is out in Nature communications!🎉 I am thankful to @JSG_Lab for pushing through to make an impact to the field. This wouldn’t be possible without all the co-authors, I am very thankful to all!😄
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This work wouldn't have been possible without the work of @BrugmannLab, @heewlim and previous and present lab members @oto_inoue, Archana Singh, Rajib Mukherjee and Meghana Ginugu. @CincyResearch @CincyChildrens
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Happy to share the final version of our paper describing that the widely used Ucp1-CreEvdr transgene unfortunately elicits complex developmental and metabolic phenotypes. This work was mainly driven by @ManasiHalurkar (now a PhD student at Purdue). nature.com/articles/s41467-0…
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Great new work by @Z_GerhartHines lab
Our new paper, "NK2R control of energy expenditure and feeding to treat metabolic diseases," is out today in @Nature.
Here we identify a single receptor that can both peripherally increase energy expenditure and centrally suppress appetite.
nature.com/articles/s41586-0…
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Thanks to @CellRepMed for highlighting our work in the cover of the December 2023 issue! @oto_inoue @CincyChildrens
The cover: Inoue et al. explore angiogenic stem/progenitor cell populations. Cover depicts AT-CD271+ prog. (yellow) promoting neovascularization (lectin, green) with engraftment (PKH26, red), and blood flow recovery (cherry blossom). Credit: Oto Inoue & Juan Sanchez-Gurmaches.
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Check out this blog explaining our recent paper @CellRepMed explaining the capabilities of adipose tissue CD271+ cells to induce revascularization in limb ischemia. @CincyChildrens @OtoInoue @heewlim
A specific type of stem cell transplant shows early-stage promise at preventing limb amputations caused by #diabetes and other conditions, according to new findings from Cell Reports Medicine. Congrats to Drs. Inoue and Sanchez-Gurmaches. Learn more: scienceblog.cincinnatichildr…
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To investigate the therapeutic potential of CD271+ cells in humans, we evaluated data from an adipose tissue limb ischemia cell therapy trial. We observed a striking correlation between successful recovery and the number of CD271+ progenitors injected.
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Analyzing subcutaneous fat samples from donors, we found that the number and angiogenic capacity of CD271+ progenitors are strikingly reduced in insulin-resistant donors. Of note, people with insulin resistance are at higher risk of limb ischemia making it a bigger problem.
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Mechanistically, the angiogenic capacity of CD271+ progenitors is dependent on functional CD271 and mTOR signaling.
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Using in vivo transplantation into a surgical mouse model of limb ischemia, we show that CD271+ progenitors have high therapeutic capacities for limb ischemia including long-term engraftment, augmented tissue regeneration and back to normal recovery of blood flow.
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In this manuscript, we show that CD271+ progenitors in adipose tissue have a prominent angiogenic gene profile over other routinely used cell sources and encompass the majority of angiogenic gene expression within the mesenchymal cells in the adipose tissue.
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This work was lead by @OtoInoue and it is a collaboration between @CincyChildrens and @KanazawaUniv_O. Glad to work with Dr Usui and Dr Takamura on this exciting project. Many thanks to @heewlim.
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Happy to share our paper on the very exciting therapeutic potential of adipose tissue derived CD271+ progenitors on limb ischemia published @CellRepMed today. cell.com/cell-reports-medici…
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The video highlighting the key steps of our protocol to measure de novo lipogenesis with @martina5wallace is now available! Hope you find it useful. jove.com/video/64219
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Our findings indicate that the hemizygous Ucp1-CreEvdr mice exhibit substantial brown and white fat tissue dysregulation affecting cold response. Homozygous Ucp1-CreEvdr mice also display high mortality, growth defects, and craniofacial abnormalities.
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New preprint from the lab! Here we describe that the the widely used Ucp1-CreEvdr transgene unfortunately elicits complex developmental and metabolic phenotypes. @CincyChildrens biorxiv.org/content/10.1101/…
This work was driven by @ManasiHalurkar (now a PhD student at Purdue)
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