Announcing my new book: The Ecstatic States of America, a manifesto for a country of the mind! Avail here: a.co/d/0etmnj3s

My co-founder @MrsToniToomey and I each recently swallowed a camera. Today we're launching Zaniah Health so you can see what's happening inside your gut too. The gut is the body's largest immune interface, and research keeps linking the gut to health far beyond digestion. We track sleep, HRV, bloodwork, and our microbiome, yet we've been overlooking the most powerful way to measure gut health: Directly looking at it. Zaniah provides at-home, physician-supervised capsule endoscopy. You swallow a small capsule that takes ~30,000 pictures of your GI tract. One of our gastroenterologists reviews the images and sends you a report with findings you can actually see, rather than a dashboard of numbers and scores that you have to decode. Here's what our capsules found: >Toni's capsule showed findings in her terminal ileum consistent with Crohn's disease. After more than 30 years of unexplained GI symptoms, she's now getting the workup to confirm it. >My capsule showed a small nodule in my stomach. Probably nothing, and I'm getting an upper endoscopy to make sure. Nearly 10 years ago I co-founded Virgo, where we've built the world's largest endoscopy video library, more than 4 million upper endoscopy and colonoscopy procedures. We also trained EndoDINO, a foundation model for endoscopy, using over 130,000 of those videos. Zaniah is where we put that AI to work with capsule endoscopy. Right now, Zaniah is for adults who want to see what's happening inside their gut. Longer term, we're researching how the gut can reveal early signs of disease beyond the GI tract. Zaniah doesn't require a referral or insurance coverage, and it's HSA/FSA eligible. Our physicians review eligibility before the kit ships. The waitlist is now open. Join by December 31st to lock in the $1,499 launch price. It goes up to $1,999 after then, and there's no payment required to join. Waitlist link below. Follow along @ZaniahHealth

There is no good reason for mosquitoes to exist in wealthy countries today. New technologies can get rid of the mosquito species that cause diseases like dengue, yellow fever, and malaria; and others can prevent them from carrying those diseases. worksinprogress.co/issue/mos… So why do mosquitoes still exist? In a new article for Works in Progress, Maya Rosen explains how state incapacity and risk aversion led to over a decade of delays and billions of unnecessary bites in the United States. Oxitec, for example, engineered an Aedes aegypti mosquito in such a way that its female offspring would die before adulthood. Through sustained releases, they showed they could reduce local mosquito populations by 80% or more, in field trials. They sought approval from the USDA in 2010, which then passed it to the FDA, which passed it to the EPA. In 2020, the EPA allowed them to conduct limited field trials in the Florida Keys. Two years ago, their experimental permit expired, and they still need another review before it can be used routinely. Their proposed field trial in California was withdrawn after public opposition. Another company, MosquitoMate, developed a technique involving Wolbachia, which also suppresses local mosquitoes. They then spent over fifteen years working through the system before finally receiving commercial registration nationwide in 2024. It seems that, sometimes, the barrier to getting rid of diseases isn’t technology at all. It’s policy and political will. New products shouldn’t get stuck in regulatory review for so long, especially if the delays are about basic questions like which agency has oversight over the product, rather than testing for safety. Though some of those uncertainties were being addressed, the broader changes haven’t materialized. After Biden’s 2022 executive order, the agencies planned to update how their coordinated framework was implemented. But Trump rescinded the order last year. Meanwhile, the EPA unit that reviews new mosquito control products is still a small office backlogged in reviewing a wide range of products. Mosquitoes are a policy choice. We can get rid of them. Will we choose to? worksinprogress.co/issue/mos…

🚨 WATCH: Andy Burnham fights away tears as he pays tribute to his late dad Roy "Whatever its flaws, this country gave my dad a good life... if only he had been able to appreciate that moment in Downing Street... the son of a man who failed his 11+ becoming Prime Minister"

🚨 WATCH: Andy Burnham issues a diagnosis of Britain "The British right talk about taking back control, NEVER let them forget that they are the ones that gave it away in the first place"

I will build the Britain my dad wanted to see.

"Hunter trained himself to be wasted and proficient. That was important to him." Chloe Sells was Hunter S. Thompson's assistant at Owl Farm and photographed it. She talks acid, communal weed, AI and peanut butter Bloody Marys with @meninvera in @HIGH_TIMES_Mag: hightimes.com/culture/chloe-…

Impressive. This set of talks, along with the new America dot gov website, has the unmistakable feel of an Apple launch event. They're rebooting the federal government as a tech startup. Several observations. (1) First, with this new AI interface to the entire federal government, if it works as promised, there won't be a single American who can't say their life wasn't helped at least in part by AI, or that the benefits accrued solely to zillionaires. This in itself cannily mitigates anti-datacenter sentiment. (2) Second, Joe Gebbia and Marco Rubio's talks on simplifying name changes and passport filings introduce a completely new era where the US government is actually launching tangible features that benefit users. (3) Third, this launch event in and of itself may visibly drive reform. It could become much more important than the State of the Union. Unlike laws, code is user-visible, and can be instantly audited by the public, as Obama found out with the failed obamacare website launch. So: the annual America dot gov event may be substance, whereas SOTU is traditionally optics. I wouldn't be surprised to see the President present at the next one. (4) Fourth, this kind of event is a perfect example of where tech and red cooperate best. They both hate bureaucracy. Automating paperwork with code reduces the power of statists over both capitalists and nationalists. It's also hard to undo by other admins: once you digitize a process, hard to turn it back to paper. (5) Fifth, it's an obvious point perhaps, but think about how much influence YCombinator has had in 20 years. From Gebbia's Airbnb joining their 2009 batch to a complete overhaul of the user interface of the US bureaucracy, and thus the US government. (6) Sixth, this is another take on the network state. The functional part of the US (the network, meaning tech) is merging with and partially reforming the dysfunctional part (the state, meaning bureaucracy) by automating 20th century paper forms. As a tech startup, there will no doubt be bugs and user issues and so on, but unlike with paper laws those issues will be visible and the code fixes will be verifiable. A new era of AI America. Rooting for them.

🎞️ The next wave of cinema won’t follow the old rules. Submissions are now open for Flick AI Film Festival, celebrating a new generation of filmmakers using AI to create their own cinematic language. No traditional production setup required. No permission needed. Just make something only you could make. Submit by Dec 15, 2026. Festival: Jan 20, 2027. Link in replies ↓

.@TonyRobbins at the America.gov launch: "Today, we're going to see a bold vision that's been turned into reality — one that forever can change how government recognizes you, how it respects your time, and how it actually serves you."

Introducing dots, powered by GPT-6 Astra. Remarkably capable, always-on agents built to handle everything.

SECRETARY RUBIO on AMERICA.GOV PASSPORTS: No printing forms, no drugstore hostage photo, no appointment, no line, no middleman that you're paying to do something that should be available to you.

SECRETARY RUBIO on AMERICA.GOV: This is really going to be a revolution in the way that government works for the average American.

Chief Design Officer @jgebbia officially unveils America.gov, the new online home for the United States of America

If a journalist and a poet witnessed the same event, the journalist might describe it more accurately. But the poet will uncover a deeper truth. We sent a poet into the latent space…now we’re beginning to understand it at a deeper level.

In the Mood for Love (2000) is one of those rare films that even if you watch it muted with no subtitles, you will still be able to appreciate how brilliant it is. The visuals alone are perfect.

straight out of scifi that a minister of defense is posting this vid on x

Welcome to Latent Space, the inner universe of AI models

The solution to the AI safety crisis is more AI axios.com/2026/09/29/the-fut…

Introducing "Artificial Creativity". One-shot 34-minute film! Generated via Claude Sonnet 5.5 (high). Watch till the end for its surprising conclusion. I can't even imagine what the Opus 5.5 version will look like! claude.ai/artifact/69ZqAE4Sz…

every cigarette you smoke acutely fucks with endothelial function, reduces NO availability, constricts blood vessels and impairs microcirculation. you're speedrunning vascular aging and when you fuck with endothelial function, you're fucking with circulation EVERYWHERE. brain. heart. kidneys. skin. dick. YES I SAID DICK. literally every tissue that depends on blood getting where it's supposed to go. unfortunately, in adult vasculature, endothelial cells can take years before being replaced. this is why Vesugen is every smoker's DREAM. and potentially every old person's too. - targets the exact tissue smoking keeps fucking with - restores blood vessel growth and repair signaling - reduces excessive vasoconstriction - supports endothelial repair and regeneration - supports microcirculation - improves your skin via stimulation of skin fibroblasts - gives you disgustingly prominent veins popping up everywhere REJUVENATING your vasculature. 30d on 60d off. 1-2mg taken in the morning. the only oral brand that is actually dosed properly: US Vesugen: yourprotocol.co/products/ves…