Growth hormone peptides are often marketed for muscle building, energy, fat loss, and staying youthful. But what are they actually doing inside the body? @jonkmd says most people should think carefully before taking something that could shift the body’s hormone system off balance. He warns that peptides working at the hormone level come with unanswered questions around cancer risk, kidney injury, and other potential downstream effects. Are the promises of growth hormone peptides worth the serious long-term risks? | @drjaredament and @JonKMD Watch here: l.prageru.com/3Tkl9d2

The University of Arkansas just launched the 1st U.S. based injectable BPC-157 Randomized Controlled Trial for tissue healing. They’re studying post-rotator cuff surgery healing through objective measures like strength testing, MRI, and range of motion. Also patient reported questionnaires on recovery (PROMs). This is what the science community and physicians needed. Enrollment starts Early 2027. First data likely to be seen Early 2028. I will keep you updated. clinicaltrials.gov/study/NCT… #bpc #bpc157 #peptide #peptides #science #research

Here we go.

Peptides are everywhere, but do consumers actually know where they come from? Dr. Jared Ament says the problem is not that all peptides are bad; the real concern is sourcing. Much of today’s peptide market runs through the gray market, even when a clinic or provider is involved. Is third-party testing enough before injecting something marketed for healing, energy, or longevity? | @drjaredament and @JonKMD

Peptides, supplements, GLP-1 weight-loss drugs, NAD, IV drips, and “longevity stacks” are everywhere. But how much do people really know about what they are putting into their bodies? Dr. Jared Ament and Dr. Jon Kanevsky join this new episode of Real Talk to explain the potential benefits of peptides, why so many Americans are experimenting with them, and why the gray-market peptide industry can be risky. They break down FDA approval, third-party testing, China-based sourcing, growth hormone peptides, Ozempic, retatrutide, creatine, NAD, and the role of AI in helping patients research their own health. We also discuss why good medicine requires both curiosity and humility. | @jonkmd and @drjaredament

you have no idea how far this goes. This is just the tip of the iceberg

1/8 I'm a cardiologist. We chase LDL like it's destiny. A UK Biobank study of 95,559 people just whispered something louder: REM sleep may be the new LDL.

So the opening acts cancelled and his own band quit. Ed Sheeran says hold my beer. 😉

A beautiful surprise

in the first chapter of healthcare AI, the battleground was access to longitudinal clinical data. in this next phase, it will be access to biological specimens: tissue, blood, synovial fluid, and other samples containing 1,000× more information, linked to clinical context and longitudinal outcomes. the winners will be those who can access, assay, and interpret these specimens at the lowest cost and highest resolution.

The data is slightly more doom and gloom when seeing the overall chart (left). Yes, influencer is no longer top dream job and sees a huge drop from last year, but so does everything else. Interest in getting any career has declined across the board while the "figuring out" section is higher. I think this sentiment resonates globally. Younger generations are indecisive because the entire job sector is indecisive. Probably will stay this way a few years until things are more clear. I still think anything that requires complicated physical skills will be the way forward (at least for the next 2 decades).

We Must Pace the Frontier: I’ve written a new essay on why the AI industry should slow down, with a three-part plan for doing so. Anthropic is unilaterally committing to the first of these steps. We’ll provide third-party evaluators with permanent, employee-level access to our systems, so that they can verify adherence to our safety measures, report on incidents, and assess models’ alignment during training. You can read the full post here: darioamodei.com/post/we-must…

Kasparov was the best chess player in the world. He was sure that even a machine calculating a billion positions a second couldn’t overcome human anticipation, intuition, and imagination. He beat Deep Blue in 1996. The machine beat him in 1997. Chess isn’t AGI. But the confidence in human specialness aged badly. A lot of people sound the same way now when they talk about controlling machines smarter than us.

AlphaFold: predicting the protein structure from amino acid sequence for >200 million proteins (awarded @NobelPrize) Today Alpha Genome Atlas: predicting the molecular impact of all 9 billion variants of the human genome nature.com/articles/d41586-0…

Autonomous medical AI just crossed a line: Vara’s CE-marked system can clear mammograms it calls “clearly normal” without a radiologist…while routing the rest to human review and reverting if performance drifts. The future is not “AI replaces doctors,” but monitored delegation. Via @MedTechDive medtechdive.com/news/vara-re…

This is a fascinating hypothesis on sleep. If you sleep for 8 hours and still wake up exhausted, the reason may be "micro-arousals." These are brief sympathetic spikes that can change your HR, HRV, breathing, and move your body toward fight-or-flight. You may never actually notice this as they last for seconds. But if they keep happening throughout night, your sleep may look fine on your wearables, but your nervous system was being pulled out of a stable recovery state. There's this sleep company called DUSQ that's building a device around this idea. Basically, it tracks all HR, HRV, breathing, movement, sympathetic activity to detect these "micro-arousals." Then they use closed-loop neuromodulation behind ear to calm this response in real time. This still needs a clinical validation, but the underlying idea is truly fascinating.

No company will unlock the *truths* of the brain like Neuralink will:

Doctors X-rayed pregnant women routinely in the 1950s to check which way round the baby was lying. Nobody thought it was dangerous. Alice Stewart noticed childhood leukaemia rising sharply in Britain and set out to find why. She and her team interviewed the mothers of 1,400 children who had died of cancer, and 1,400 mothers whose children were alive, and asked them the same questions. The pattern showed up in the first 35 pairs. Children who had died were about twice as likely to have been X-rayed in the womb, and a single scan at the dose used then appeared to be enough. She published in 1956, and the response was outrage. Radiation was the technology of the future in the 1950s, and the claim that a low dose could cause cancer years later contradicted what the entire medical and nuclear establishment believed. Her methods were attacked. Her funding suffered. Doctors carried on X-raying pregnant women. It took roughly 25 years for the medical world to come round. Pregnant women were still routinely X-rayed into the late 1970s. Two decades after she told them to stop. She retired in 1974 and did her most contested work afterwards, in her seventies, examining the health records of American nuclear weapons workers. Her findings there were unwelcome enough that the Department of Energy cut off her access to the data. She spent 14 years fighting them and testified before Congress, and in 1990 the records were opened to independent researchers. She died in 2002, aged 95. The children who were never X-rayed have no idea who she was. history.rcp.ac.uk/blog/alice…

Tempus trained a foundation model on 1.67M real cancer patients, fusing clinical trajectories with DNA, RNA, and H&E pathology into one patient-state embedding. Overall-survival AUC jumped 0.563 to 0.774, and treatment-benefit ranking improved in 9 of 11 cohorts. We have argued for years that multimodal models beat curated features in oncology. This is strong evidence at real scale. arxiv.org/abs/2608.24688

Introducing Index Today we're coming out of stealth with the largest and most diverse robot dataset to scale general purpose robots To date we've crossed 264,000 app downloads and uploaded 16 million videos