Visiting postdoctoral fellow - Glancy lab of Muscle Energetics, NHLBI, NIH. Interested in all things skeletal muscle.
Bethesda, MD
- Tweets 121
- Following 449
- Followers 455
- Likes 16,210
Jonathon Smith retweeted
Upcoming Postdoc Position! With Chris Nelson’s lab at U of A, we are looking for a fully supported 2-year postdoc to work on muscle gene editing and detection of gene doping in vivo. If interested, email myself and Chris: kmurach@uark.edu and nelsonc@uark.edu #myotwitter
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Jonathon Smith retweeted
Our latest study connects reduced NR4A3 expression with physical inactivity and indicates that NR4A3 downregulation in human muscle has adverse effects on glucose metabolism and protein synthesis.
Congrats to @JonoSmith01 @DrBMGabriel @NicoPillon & team!
sciencedirect.com/science/ar…
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Nice to have our latest up on @biorxivpreprint 🤓 Here we build upon previous work from us (and others) to investigate NR4A3 in the context of skeletal muscle inactivity 🧬 Feedback welcome!
Latest preprint from our team!
Downregulation of NR4A3 During Inactivity Alters Glucose Metabolism and Impairs Translation in Human Skeletal Muscle
Plus, a new meta-analysis of transcriptomic datasets from human bed rest & limb immobilisation studies!
biorxiv.org/content/10.1101/…
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After what feels like the shortest 6 years, I had the pleasure of defending my thesis last week! 🤓 Thanks to @MarcasBamman @EmmaRAndersson @teixeiralabki and @Michael68288255 for great questions and a really fun discussion 🧬 #PhDone
Dissertation day for Jon Smith! @JonoSmith01 Jon defends his PhD work on “Skeletal Muscle Responses to Physical Activity in Health and Metabolic Disease” his opponent is Professor Marcas Bamman @MarcasBamman
Defense is now underway @karolinskainst
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Nice this work is finally out: “Myotube growth is associated with cancer-like metabolic reprogramming and is limited by phosphoglycerate dehydrogenase”. See 🧵 from @HeWaHippo 👇
So happy that this is finally out now (do not ask why it took this long, it was not the reviewers!). Cancer cells reprogram their energy metabolism to generate substrates for anabolism and we think hypertrophying muscles do the same. More to come! pubmed.ncbi.nlm.nih.gov/3787…
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Jonathon Smith retweeted
I really like this comparison of mouse and human muscle by @DyarKen and @JonoSmith01. This is in the supplements of the @NatRevMCB article with @JuleenRZierath. Don’t overlook the bonus coverage! #myotwitter nature.com/articles/s41580-0…
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Jonathon Smith retweeted
We've just published a tour-de-force Review on the metabolic regulation of skeletal muscle in response to exercise 💪🏼🏃🏾
Fantastic effort by the authors: @JonoSmith01
@KevinMurachPhD @DyarKen @JuleenRZierath
This Review is free to access for 30 days!
go.nature.com/3IGMr4E
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Our ‘Exercise metabolism and adaptation in skeletal muscle’ Review is out in @NatRevMCB! Learnt a lot writing this with @KevinMurachPhD @DyarKen and @JuleenRZierath. Be sure to check out the supp too - good amount of info there that we weren’t able to fit in the main text 🏃♀️🏋️ 🧬
Our latest
Exercise metabolism and adaptation in skeletal muscle | Nature Reviews Molecular Cell Biology
A great collaboration with @JonoSmith01 @KevinMurachPhD @DyarKen
👍 nature.com/articles/s41580-0…
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Jonathon Smith retweeted
No, skeletal #muscle cells do not respond to extracellular #succinate. Makes sense: they don't have the receptor SUCNR1/GPR91! New #research from us @karolinskainst published in @AJPEndoMetab journals.physiology.org/doi/…
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Jonathon Smith retweeted
Our MetaMEx.eu database now includes mouse transcriptomics. We hope this will help reduce animal use in research by providing useful data on #exercise responses. Thanks @UtanDjurforsok for the support! #myotwitter
ALT Mice in a small house in a cage. Credit https://www.pexels.com/@tanner-johnson-10216/
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Jonathon Smith retweeted
Distinctive exercise-induced inflammatory response and exerkine induction in skeletal muscle of people with type 2 diabetes. @NicoPillon @srp_diabetes
science.org/doi/10.1126/scia…
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Childhood hero. Bumped into him randomly once, on holiday. Took the time to chat to a young fan and aspiring keeper. Meant the world to me. Absolute legend.
RIP #TheGoalie
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Jonathon Smith retweeted
Last week's most mentioned article is from @AJPEndoMetab:
Three weeks of interrupting #sitting lowers fasting #glucose and glycemic variability, but not glucose tolerance, in free-living women and men with #obesity
ow.ly/f0jY50G9KWU
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Jonathon Smith retweeted
Our latest: Three wks of interrupting sitting lowers fasting glucose & glycemic variability, but not glucose tolerance, in free-living women & men with obesity @JonoSmith01 @MSavikj @AJPEndoMetab
pubmed.ncbi.nlm.nih.gov/3415… via @NYTimes nytimes.com/2021/09/08/well/…
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Jonathon Smith retweeted
What mitochondrial ATP synthesis actually looks like 😨
#medtwitter
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Jonathon Smith retweeted
Frequent activity breaks from sitting may improve fasting blood sugar (glucose) levels and stabilize daily fluctuations. Our new study is highlighted this month @AJPEndoMetab
Congrats @JonoSmith01 @MSavikj and team!
.@AJPEndoMetab study about daily activity breaks and glucose levels (ow.ly/Ud5f50FS43u) featured in @usnews story: ow.ly/eAky50FS43s. Also read our press release and watch author interview: ow.ly/WVC850FS43t #ISpyPhysiology
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Our latest, in press @AJPEndoMetab 🤓
Three weeks of interrupting sitting lowers fasting glucose and glycemic variability, but not glucose tolerance, in free-living women and men with obesity | 👍@JonoSmith01 @MSavikj @DrBMGabriel @JohnAHawley @DavidWDunstan @AnnaKrook_KI Erik Näslund & team!
journals.physiology.org/doi/…
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Jonathon Smith retweeted
Breaking sitting marginally lowers glycemic variability; new research in press:
journals.physiology.org/doi/…
#obesity #insulinresistance #glycemia #lipids @karolinskainst @BakerResearchAu @ACUmedia @JuleenRZierath @AnnaKrook_KI @JohnAHawley @DrBMGabriel @JonoSmith01 @MSavikj
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Excited for this to come out! Real collaborative effort and the 1st first author paper of my PhD, co-first with @MSavikj 🥳
Great news to wake up to!
“I am pleased to inform you that your manuscript "Three Weeks of Interrupting Sitting Lowers Fasting Glucose and Glycemic Variability, but not Glucose Tolerance, in Free-Living Women and Men with Obesity," has been accepted!”@AJPEndoMetab 👍@JonoSmith01
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Jonathon Smith retweeted
Here, we discuss the many actions of insulin in skeletal muscle, including GLUT4 translocation, glycogen deposition, lipid accretion, and protein deposition. doi.org/10.1016/j.cmet.2021.…
Such a joy to write this with my science heroes @proferikrichter and Amira Klip🙏
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