As my stay in Roma comes to a close, I can highly recommend the Massimi City Garden Hotel. A bit north of the Vatican, and you have to use taxi, ride share, bus, metro, or limited space on hotel shuttle. They make up for that by being economical and a breakfast to die for. Grazie to my hosts!
Of course, the most economical way is by bus and Metro. Taking those as to the immersion experience. I recommend the 7-Day ticket if you're going to be here for more than 4 days. 990 bus not that reliable, the 913 is. 913, though, you have to climb some stairs at the bus stop. I hated those stairs, but it was worth it to stay at this wonderful location.
@BeatriceAnihiri , notice the pin on the gentleman.