Research Lab of Dr. Raghu Kalluri. Unraveling the biology of cancer and other diseases to develop novel diagnostics and therapeutics.
Texas Medical Center, Houston
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2026 Hill Prize in Medicine Recipient Raghu Kalluri, M.D., Ph.D., has been appointed Senior Vice President and Chief Scientific Officer at @UTMBHealth and will serve as the founding Executive Director of the UTMB Cancer Center. Read More: buff.ly/4b0b1df
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Now online ➡️ we identify CDK8 as a resistance mechanism across several Kras inhibitors including daraxonrasib. Targeting CDK8 alone can overcome resistance and sensitize tumors to checkpoint immunotherapy with curative outcomes ‼️
link.springer.com/article/10…
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Grateful to @break_cancer @lustgartenfdn and @UTMDAnderson for funding this work. Check it out now in @embojournal
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Kalluri Lab retweeted
In @embojournal from @KalluriLab & @mcandrews_kate @UTMDAnderson dissecting a novel mechanism of resistance to KRAS inhibitors:
CDK8 remodels the tumor microenvironment and promotes resistance to KRASG12D inhibitors and daraxonrasib in #PancreaticCancer
link.springer.com/article/10…
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We had a blast 💥 catching up on paper celebrations. Three recent lab publications, by @krishnaniyer199 in @Cancer_Cell, @Bingruilii in EV, and @rkalluriMDPhD in @ImmunityCP, were added to the wall. 🍾
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Proud lab moment! We’re happy to announce Raghu’s election to the @aimbe College of Fellows 🤩
Congrats, Boss!
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Houston, we have a solution! @SaurLab and @Bingruilii are on the scene at NASA 🚀
Glad to have Dieter with us in Houston for a terrific week of science!
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We’re honored to be part of the @break_cancer Conquering KRAS TeamLab, highlighted in @TheCancerLetter this week. Amazing work by our colleagues and friends, with more results on the way!💡
cancerletter.com/conversatio…
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Raghu delivered the plenary keynote lecture on biology and function of exosomes in cancer at the SPARC cancer research conclave on Exosomes in Cancer in Vishakhpatnam, India. Discussion after lasted 45 minutes!
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We asked AI to summarize the 2024 Meeting of @AAEV_org, but it fell short of expectations.
We wrote about our experience with multiple LLMs, and their performance identifying speakers, citations and terminology. We humans are still in business, for now.
sciencedirect.com/science/ar…
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Kalluri Lab retweeted
These researchers and institutions are bringing home 2026 Hill Prizes. houston.innovationmap.com/hi…
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Today the lab celebrated the well-earned retirement from @MDAndersonNews of our IT and Tech Support HERO 💪, Gil.
Every discovery, publication, and therapy emerging from the lab is credited in part to Gil, our silent author, without whom none of it would be possible 💙
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💡Curious about the origins of iExosomes?
➡️ Read about the decade-long journey from concept to clinical trial, over on the Ras Dialogue Blog by Frederick National Laboratory
New RAS Dialogue:
Exosomes in personalized medicine for #PancreaticCancer
frederick.cancer.gov/news/ex…
Great job @Val_LeBleu!
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📣Our secret is OUT!
Cancer keeps us busy, but one experiment led to another…and we invented an EYE DROP therapy for AMD!
Thrilled to share that this work has been awarded the @TAMESTX 2026 Hill Prize in Medicine
Our iEV eye drops are poised to disrupt the industry standard!
TAMEST and Lyda Hill Philanthropies are pleased to announce the recipients of the 2026 Hill Prizes. The prizes propel high-risk, high-reward research ideas with significant potential for real-world impact. Learn more about the recipients here: buff.ly/3cSReFs
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Kalluri Lab retweeted
These Houston inventors are leading their fields, from AI to chemistry to cancer research. houston.innovationmap.com/na…
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🎉 Congrats to Kalluri Lab Alum @jackie_parchem for receiving a Young Physician-Scientist Award from @the_asci. Dr. Parchem is an Associate Prof @UTHealthHouston, Maternal Fetal Medicine and preeclampsia specialist…a field with few clinician scientists. Proud day for the lab!
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✅ Clinical validation of our 2014 discovery
Hedgehog inhibitor primes PDAC TME to leverage immunotherapy as 1st line treatment in metastatic pancreatic cancer.
Trial led by @DrMhidalgo & @Perlmutter_CC 🙌
medrxiv.org/content/10.64898…
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Kalluri Lab retweeted
Are Hedgehog inhibitors making a comeback in #PancreaticCancer, this time with nuanced sequencing and combination regimen?
Preprint of 1st line clinical trial in advanced PDAC, @DrMhidalgo @Perlmutter_CC (in collaboration with @Val_LeBleu @rkalluriMDPhD):
medrxiv.org/content/10.64898…
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