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Excited to share our latest work published in @Nature, by grad student @mirazul302, currently on the job market. We uncovered clonal dynamics relating normal to tumor cells using natural and synthetic genetic changes. #SingleCell #DevBio #CRISPR #CRC #HTAN nature.com/articles/s41586-0…
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Ken Lau Lab retweeted
Location, location, location—in Inflammatory bowel disease (#IBD)
doi.org/10.1172/JCI201729
Paige N. Spencer @Paige_N_Spencer, Monica E. Brown @moni_e_brown, Ken S. Lau @KenLauLab & team @VUMChealth determine how chronic inflammatory disease can manifest in a region-specific fashion, providing a unique model of #Crohn’s disease that reveals #Chlamydia and genetic risk as a trigging combination for Crohn’s disease-like inflammation in the proximal colon.
The image shows the host-pathobiont interface in the inflamed murine proximal colon, where intracellular Chlamydia muridarum (MOMP; green) in epithelial cells induces goblet cell-specific expression of indoleamine 2,3-dioxygenase 1 (IDO1; magenta); nuclei (blue). Image credit: Monica Brown, Paige Spencer, and William Kim.
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Why does Crohn’s disease affect different regions of the GI tract? @Paige_N_Spencer tackled this in our latest study (in press @jclinicalinvest), uncovering region-specific responses that drive inflammation in the PROXIMAL colon to a pathobiont. 🔬🧬 jci.org/articles/view/201729
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Shoutouts to the collaborators and groups that made this project possible: @valdi001 @Wenhan_Zhu1 @jeremygoettel @Dr_LoriCoburn @moni_e_brown @VUBasicSciences @VanderbiltCDB
#inflammation #microbiome #Crohnsdisease #IBD
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Happy Holidays to all! Hope we can overcome the challenges of the past year in the coming New Year! (courtesy of @w_janney)
ALT Happy Holidays to all! Hope we can overcome the challenges of the past year in the coming New Year!
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Vanderbilt Symposium on AI, Spatial & Systems Biology 2025. Thank you all for coming out on the weekend! @VUBasicSciences. Key note: Dr. Jonathan Liu from Stanford on hybrid open top light sheet microscopy!
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Ken Lau Lab retweeted
Excited to speak this weekend at the Vanderbilt Symposium on #AI, #Spatial & Systems Biology 2025—hosted by @KenLauLab and @tae_hwang at @VanderbiltU’s Center for Computational Systems Biology. 🌟A stellar speaker lineup!
Agenda: vanderbilt.edu/computational… Onsite full—join virtually
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So glad to be spending a few days with @SKDevStemCell @SK_GGB @SickKidsNews to share great science and friendship! Beautiful Blue Mountain Venue.
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Ken Lau Lab retweeted
Congratulations to @K_Harsim from @KenLauLab for winning the Poster Prize at the Beatson International Cancer Conference 2025!
Thanks to @MolOncology for sponsoring this prize
#BICC2025
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Congratulations to @skotomorph for winning this year's Mentorship Excellence Award! Honored to have such an inspiring individual in our midst! @VUBasicSciences
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Proud of @Paige_N_Spencer and @mirazul302 for completing their PhD journeys with me last week. The best is yet to come!
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Thank you to Vlaams Instituut voor Biotechnologie (VIB) for inviting me to the conference on Immune Niches in Cancer & Inflammation in beautiful Bruges. Feels like walking into a Disney story. Incredible science!@cell #INCI25
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Thank you Yonsei-Severance for hosting a wonderful conference : YONSEI HTAN SCL G1's Lab K-BioX global summit 6. Have great respect for Korean science and tech. @tae_hwang @IamLinghua @DrMingyaoLi
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