🧬 Research group at @EMBLHeidelberg exploring genomes in motion | from SVs to disease mechanisms Run by lab members | posting about science & lab life

Heidelberg, Germany
Our social media presence is expanding ➡️ we’re now on Bluesky too 🌤️ Come follow us: bsky.app/profile/korbel-grou…
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Another PhD defence to celebrate! 🎉 Congratulations to Dima Olisov on defending his PhD on genome-wide profiling of loss of heterozygosity events! 🧬 And true to his love of board games, Dima’s PhD hat even came with a little game on top 🎲 All the best for your next adventure!
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🎉 #Preprint alert! Excited to share this new study from our postdoc Carsten Hain on centromeres! biorxiv.org/content/10.64898… This work presents HORoSCOPE, a computational framework that infers centromere architecture and size directly from short-read sequencing data. (1/3)
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(2/3) HORoSCOPE opens the door to studying centromere variation across thousands of genomes without requiring specialised long-read sequencing. Applying this tool to population-scale and cancer datasets revealed new insights into human centromere diversity -
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(3/3) - and uncovered a general dependency of chromosomal rearrangement locations on the position of the centromere dip region. Looking forward to hearing your thoughts! #Centromere #Genomics #CentromereBiology #Bioinformatics #CancerGenomics
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🎉Welcome to the lab, Chiara! Chiara started her internship last month and is helping us explore new dimensions. Her project focusses on applying our MAGIC platform to PDAC organoids, expanding from 2D cell cultures to 3D models.🔬 We're excited to have you!👏 #PDAC #Organoids
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🧬 It's #WorldDNADay ! From the discovery of DNA structure in 1953 - shaped by the work from Rosalind Franklin, Watson, Crick, Wilkins - to today‘s genomics. We’re still uncovering hidden genome layers with methods like Strand-seq at our lab. Same molecule, more to discover!
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🌍 Today is #WorldEarthDay! “Do we really need that many tip boxes?” Back in 2023, that question helped our lab cut plastic use by 50% for our Strand-seq protocol, without sacrificing performance. Small change. Real impact!🌱 🔗Read more here : lnkd.in/eQ4r_pKz
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Last Friday, Alice successfully defended their PhD! 🎉 Knowing Alice’s love for green and purple, we made sure everything reflected their signature colours: from the PhD hat, to our outfits, and even our nails 💜💚 Huge congratulations! Stay as colourful as you always are! 🌟
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Great insights into current research in human molecular genetics from our PI @JanKorbel5 who joined the @GHGA_DE podcast to talk about genetic mosaicism and why our cells are more diverse than we might think! Worth a listen! 🎧 (episode in German) codedeslebens.podigee.io/52-…
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🎉 Congratulations to Ilaria Cherchi for securing an @EMBO Scientific Exchange Grant! Ilaria is a visiting PhD student from the @FrancescaBZNY Demichelis Lab at the University of Trento, and she is currently exploring the contribution of telomeric dysregulation (1/2)
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(2/2) to the generation of telomeric insertions and complex cancer genomic landscapes. We're excited to see this collaboration supported by EMBO! Looking forward to the work ahead! 🔬
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Every scientist was once a curious child. 🔬 For a slightly belated celebration of International Women’s Day, we wanted to give a small reminder that curiosity and a love for questions can take you far! Happy #InternationalWomensDay ! ⭐🤍 #IWD #WomenInScience
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A (slightly overdue) welcome to our newest lab members! ☺️🎉 Our lab has grown over the past months with 🔬 Nina - PhD student 🧫 Oskar - MSc intern 🧬 Ilaria - visiting PhD student from @FrancescaBZNY’s lab 💻 Preet - MSc intern Great to have you all on board! 👋
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And we even keep growing! 🪴 Luca started his postdoc this week - welcome to the team! 🧬
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Celebrating the women and the gender-diversity in our lab today, and every day! 🎉 Happy International Day of Women and Girls in Science! #WomenInScience #WomenInSTEM #IDWGS
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Thrilled to see our MAGIC work featured as a Research Highlight in @sigtrans_sttt ! Huge thanks to @DrCeSarcoma and colleagues for their interest and for spotlighting our study on chromosomal instability. 🙏
🧬Origins of chromosomal instability unveiled by a revolutionary approach combining imaging and single-cell genomics 👀Just out in @sigtrans_sttt, you can find below our take on this wonderful work from @JanKorbel5 @KorbelGroup Nature. 2025;648:383-393 rdcu.be/e2ocm
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Korbel Group @ EMBL retweeted
Do you work in DNA replication, genome maintenance, chromosome organisation, chromatin maintenance, or a related field? 🧬🔍 Join us for the EMBO | EMBL Symposium 'DNA replication and genome maintenance: from basic biology to human health', bringing together experts and early-career researchers to drive new ideas and collaborations. Abstract submissions are welcome from researchers at all career stages! #EESReplication Session topics • Replisome structure and function • Replication in time and space • Chromatin replication and cell fate • Replication stress and genome stability • Replication-coupled DNA repair • Replication in development, aging, and cancer 📍 EMBL Heidelberg and Virtual 📅 20 – 23 October 2026 👉 Submit your abstract by 28 July: s.embl.org/ees26-13-x
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We’re back on social media! Wishing you all a Happy New Year!🎉 We hope you enjoyed the magic of the holiday season, but did you know about the MAGIC of uncovering hidden secrets in the genome? Check out our recent paper nature.com/articles/s41586-0… 🧬+stay tuned for more insights!😊
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Korbel Group @ EMBL retweeted
We are hiring postdocs! Reach out if you are keen to work in single cell and long-read genomics, computational biology, or image analysis, to study patterns of mosaicism! Our interdisciplinary are, depending on interests, geared more towards experimental or data science research.
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