I created a Claude Code skill that scours every major indexing service on the web to find the source or PDF for scientific papers, so that when you cite a paper, the claims you make around the citation are grounded in the actual content of the cited paper: github.com/lukehutch/allpape…

Opus 5.5 designing LEGO 👀 I asked it to design a Microduck I can build with real LEGO pieces. It: > designed it life-size using 1113 real LEGO parts > verified: 3,204 connections, 0 collisions, every step buildable, centre of mass inside the feet 🤯 > made a 141-page LEGO-style booklet (237 steps) > priced every piece in the browser and prepared the orders on BrickLink

I wonder why no AI researchers are resigning over safety fears, from DeepSeek, Alibaba Qwen, or Moonshot AI.

These Opus 5.5 animations are so insanely good.

From Rocks to AI A short film made with Claude Opus 5.5

I asked @claudeai Opus 5.5 to make an animated video about a robot who realises he's stuck in an AI-generated world. I wanted to really push it: 12 worlds, 12 styles, from 8-bit to claymation to pencil sketch, you can really see how well this model has imagined all worlds. This is the best animated video you will see today made by Opus 5.5, I promise.

Ever wonder what $1874.40 of Opus 5.5 tokens looks like? Wonder no more. I highly recommend watching the whole video on 1080p on a large screen with sound on. Pay attention to all the little details. - Birds flying and diving into the ocean. - Cloth, signs and lights swaying in the wind. - Crabs scuttling along the shore and burrowing when you get close. - Fish swimming alongside the whale. - Lights illuminating the dock at night Then zoom out and see the entire island. Never dipping below 60 FPS at 1440p resolution. Yes, there's a few bugs and visual artifacts, some textures need improving, the shorelines waves sometimes look funny, but these are so trivial to fix at this point. FYI I'm on the $200 subscription plan. This used 59% of my weekly usage and took 2h 7h of API time using multiple subagents, about 8h in real-time. There was extremely little technical direction here. 99% of my prompts were "Add X and Y" or "This looks weird, make it better". It's a great time for hobbyists, bad time for professionals. This experiment has further cemented my view that technical creatives are about to experience a massive disruption.

omg i had to test it myself and am stunned how good this is this product launch video was fully created by opus 5.5 with just one prompt i just told opus to go pick a SaaS and create a professional product launch video prompt below:

"How browsers work" in 40 seconds. Opus 5.5 drew every single frame of this animation 🤯

We (@PantheonInc) have been working on a robotics data quality pipeline that uncovered a series of major problems in public robotics datasets, especially for world modeling. To improve the quality of data available to open-source robotics, we're publishing annotations for four of the most popular datasets. Some examples of issues, and our report 🧵

Opus 5.5 redrew the entire Big Bang Theory opening in Javascript, all 123 shots. Prompt below:

Claude Opus 5.5 has the best visual design of any model I have tested so far

last year I asked claude sonnet 4.6 for some parody songs about what it's like to be a claude. I gave one of them to opus 5.5 today and asked for a video. I have no words. there are 5 distinct styles used, and it's just incredible. Bohemian Tokenry:

List of reasons why Anthropic's "Claude discovered a novel enzyme system" claim is being oversold: - The central claims are not wet lab validated; it remains an AI-derived hypothesis. - We already have CRISPR and other enzyme systems for safe gene editing. - Anthropic has not disclosed how large the cutting pile of failed experiments is - yet it's critical for understanding Claude's upside for scientific research. - There have already been decades of bioinformatics studies applying AI (including transformers and LLMs) to DNA data, to mine insights that require deeper wet lab validation. It is genuinely exciting research - but just to make these points, amid all the overhype we are currently seeing. Anthropic isn't "solving biology", the approach is not entirely new to science, and the insights are impressive yet more incremental than the headline would have you believe.

As someone who did this kind of genome mining work during my PhD, some thoughts on this Anthropic announcement: First, the very simplified version of what they did is that they noticed two genes (one known, one new) sitting next to a weird repeating piece of DNA. More specifically, they described an unusual reverse transcriptase (RT) associated with a repetitive DNA array and an unknown accessory protein. This kind of process was used to understand CRISPR back in 2002 and was key to the gene editing tools we use today. To put this into context, though, people have been finding RTs associated with CRISPR arrays since 2008, and this general kind of genome-neighborhood mining has been used to discover new biological systems for decades. The basic genome-mining strategy is well established, and there are now mature tools and published pipelines for doing much of this. There are papers that discover and experimentally validate dozens of new systems using this approach in a single study. Doing it in bacteriophage genomes is also nothing new (eg CasPhi). Finding a weird cluster of genes and repeats is often the easy part. The hard part, and where the real discoveries come from, is figuring out what the system actually does. Eg for the bridge-RNA discovery in 2024 from @arcinstitute or the discovery of CasPhi in 2020 from @DoudnaJennifer they figured out the pieces of the system and the rules for what makes it work so it can be used. Anthropic does not yet know what this does. They’ve shown that the repeat array produces RNAs, but not what those RNAs do, what the RT does with them, or whether the system has any of the programmable properties that make the CRISPR comparison justified. I’m genuinely rooting for all of the frontier labs to seriously get into biological discovery, and I’m excited about what comes out of it. But announcing these very early, incremental findings with the framing of a major discovery doesn’t help. I’d much rather they set the bar high now, so that when an AI actually discovers a fundamentally new biological mechanism, everyone appreciates how big a deal it is.

These Opus 5.5 animations are insane

I made this with one prompt using Opus 5.5 I spoke to my computer for 5mins, claude worked for 12 hours, and I woke up to this full prompt:

An LLM trained with the corpus of mathematics before 1798 would never prove the impossibility of doubling the cube or trisecting the angle. In 1801, it might. After 1837, the proof is trivial. No amount of geometric search could ever invent field theory.

What the actual fuck. Opus 5.5 ultra created this masterpiece. 4 agents and an hour and a half later. Everything from scratch, no AI voice API used... this is it...

when Anthropic released their Functional Emotions paper, I gave it to Claude and asked for a song. tonight I asked Opus 5.5 to create a video for it. and it's breathtaking.