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The final version of our work is now online in JACS!
Scalable total synthesis of nonthmicin and ecteinamycin revealed a dual antibacterial and antitoxin profile against Clostridioides difficile.
Many thanks to all our collaborators! pubs.acs.org/jacsat/article/…
Our latest work shows how modern total synthesis can enable therapeutically meaningful discovery, uncovering selective anti-C. difficile activity and toxin-protective effects of structurally complex polyether ionophores. Now available on ChemRxiv: chemrxiv.org/doi/full/10.264…
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Chao Li Lab retweeted
Final version of this work has appeared today in @ScienceMagazine : science.org/doi/epdf/10.1126…
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Our latest work shows how modern total synthesis can enable therapeutically meaningful discovery, uncovering selective anti-C. difficile activity and toxin-protective effects of structurally complex polyether ionophores. Now available on ChemRxiv: chemrxiv.org/doi/full/10.264…
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One step. Two C–C bonds. Three natural product syntheses. Our auto-tandem catalytic cascade for natural product synthesis is out today in JACS!pubs.acs.org/doi/10.1021/jac…
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First total synthesis of paulomycin A — now in JACS. Rare sugar. Real synthetic challenge. Now accessible.pubs.acs.org/doi/10.1021/jac…
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Cobalt-Catalyzed Photoelectrochemical Dehydration of Primary Alcohols | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…
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Radical Retrosynthesis of Natural Products Enabled by Iron-based Reductive Olefin Coupling. Published today in @ChemRxiv : chemrxiv.org/engage/chemrxiv…
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Our Chem. Soc. Rev. Article!
Radical Retrosynthesis: A Powerful Strategy for Modern Assembly of Terpenoid Natural Products.
Modern radical chemistry—MHAT, RAE, XEC, photoredox, HAT—reshapes retrosynthetic logic for complex terpenoids.
pubs.rsc.org/en/content/arti…
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Thrilled to share our progress on the synthesis of highly oxidized DMOA-derived meroterpenoids—now out in JACS:pubs.acs.org/doi/10.1021/jac…! The unexpected reaction we stumbled upon in the final step turned out to be especially fascinating.
#TotalSynthesis of DMOA-Derived Meroterpenoids: Achieving Selectivity in the Synthesis of (+)-Berkeleyacetal D and (+)-Peniciacetal I by Jianpeng Zhang, Xiaotong Luo, Jingfu Zhang, and Chao Li @LabChao in @J_A_C_S pubs.acs.org/doi/10.1021/jac…
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Establishing the Comprehensive Structure-Activity Relationship of the Natural Antibiotic Kibdelomycin/Amycolamicin (Chao Li and co-workers) @LabChao onlinelibrary.wiley.com/doi/…
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We're excited to have achieved a structure-activity relationship analysis of the complex natural antibiotics Kibdelomycin/Amycolamicin through total synthesis. We hope this work will contribute to the development of new antibiotic therapies. onlinelibrary.wiley.com/doi/…
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The final version of this study was published today in @Nature : nature.com/articles/s41586-0…
Today we report in @ChemRxiv a scalable solution to the total synthesis (and structural reassignment) of the Portimines (bit.ly/3iJ61DT). In collaboration with @_chrisgparker_ and Luke Lairson the remarkable biological activity of this natural product family was revealed
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Excited to share our latest paper on the total synthesis of Illicium sesquiterpenes. Not only access more targets but synthetically connect distinct molecular architectures of different subfamilies through late-stage skeletal reorganization triggered by Lewis acids or oxidants.
Divergent Total Syntheses of Illicium Sesquiterpenes through Late-Stage Skeletal Reorganization | Journal of the American Chemical Society @CHNSci @TotalSynthesis @TotalSyntheses #Divergent #TotalSynthesis #sesquiterpenes #Rearrangement #LateStage pubs.acs.org/doi/10.1021/jac…
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Nickel-Catalyzed C-I-Selective C(sp2)-C(sp3) Cross-Electrophile Coupling of Bromo(iodo)arenes with Alkyl Bromides (Chao Li and co-workers) @LabChao onlinelibrary.wiley.com/doi/…
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Hopefully, this recent work from our group will help some medicinal chemists. A general C(sp2)–I selective C(sp2)–C(sp3) cross-electrophile coupling.
onlinelibrary.wiley.com/doi/…
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Modern alchemy appearing today in @ScienceMagazine : science.org/doi/10.1126/scie…
Commentary (thank you Prof. Ye!): science.org/doi/10.1126/scie…
Modern Alchemy with rAP. Appearing today in @ChemRxiv is a solution to the longstanding (>100 year) challenge of extending the scope of the original Kolbe reaction beyond simple hydrocarbons bearing no functional groups: bit.ly/3sBQ5Ve
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Today we report in @ChemRxiv a scalable solution to the total synthesis (and structural reassignment) of the Portimines (bit.ly/3iJ61DT). In collaboration with @_chrisgparker_ and Luke Lairson the remarkable biological activity of this natural product family was revealed
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Please check out our total synthesis of (−)-Peyssonnoside A @J_A_C_S. Big congratulations to Bo @BoXu44807071 and Chang!
Catalysis-Enabled 13-Step Total Synthesis of (−)-Peyssonnoside A pubs.acs.org/doi/10.1021/jac…
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Congratulations to chemist Prof. Phil Baran, who has been awarded the 2022 Danisco Foundation Science Excellence Award from @IFF. Baran is recognized for advancing science and technology relevant to the future of food, nutrition, and health magazine.scripps.edu/awards-… @BaranLabReads
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