PetersLab@LabPeters

The Peters lab investigates T:B cell interactions in CNS autoimmunity, always digging deep for the next discovery!

Joined November 2020
Very happy to finally share this. Cortical hyperexcitability in ALS patients & tg mice can be assessed by means of phase-amplitude coupling & is driven by a noradrenergic deficit. Major team effort! Big thanks to Véronique Marchand-Pauvert and the fantastic Caroline Rouaux.
FunSy@FunSyCNRS
14 Mar 2024
Thrilled to see this one out! Incredible teamwork with Véronique Marchand-Pauvert, @liebscher_lab, and the amazing Caroline Rouaux. Grateful for this wonderful opportunity! science.org/doi/10.1126/scit…
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Very happy to share one of the first works from my lab: A B cell–driven EAE mouse model reveals the impact of B cell–derived cytokines on CNS autoimmunity | PNAS pnas.org/doi/10.1073/pnas.23…

A B cell–driven EAE mouse model reveals the impact of B cell–derived cytokines on CNS autoimmunity...

In multiple sclerosis (MS), pathogenic T cell responses are known to be important drivers of autoimmune inflammation. However, increasing evidence ...

pnas.org
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We developed a B cell-driven EAE model, where B cells provide the critical stimulus for disease development. Our system allows for genetic manipulation of B cells prior to transfer and thus is a tool to investigate B cell pathogenicity.
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I am very thankful to all who contributed and especially proud of my students Katarina, Courtney and most of all Anna, who developed this project, lifted it off the ground and saw it through to the end!
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Very happy to share this preprint from my lab and so proud of my team and collaborators! Want to see (live!) what T and B cells are doing in meningeal follicles? Check it out: T:B cell cooperation in ectopic lymphoid follicles propagates CNS autoimmunity biorxiv.org/content/10.1101/…

T:B cell cooperation in ectopic lymphoid follicles propagates CNS autoimmunity

Meningeal ectopic lymphoid follicle-like structures (eLFs) have been described in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE), but their role in CNS...

biorxiv.org
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We analyzed the phenotype of B cells in eLFs and found that they are not only engaged in GC reactions but also show enhanced APC-function.
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Via live imaging with @KawakamiLab we show that B cells reactivate T cells in eLFs to maintain proinflammatory T cell effector function!
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👯🪩 For Tomorrow's 2nd ppt #JournalClub Ramojus Balevicius @karolinskainst will discuss a #preprint by the Peters lab @LMU_Muenchen describing a pro-inflammatory role of T:B cell interactions happening in lymphoid follicles-like structures in EAE🧠🧨 biorxiv.org/content/10.1101/…

T:B cell communication in ectopic lymphoid follicles in CNS autoimmunity

Meningeal ectopic lymphoid follicle-like structures (eLFs) have been described in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE), but the cellular...

biorxiv.org
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Very proud that we could contribute to this beautiful story about innate-like functions of CD4 memory T cells from the Joller Lab!
JollerLab@JollerLab
30 Mar 2023
1/Want to know why people differ in their response to new immune challenges? Check out our new preprint lead by brilliant PhD students Niko Rakebrandt and Nima Yassini who investigated innate functions of memory Th1 cells and their impact on infections as well as autoimmunity!
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PetersLab retweeted
GerdesLab@MS_TWIN_STUDY
4 Feb 2022
Great thanks to ⁦@mssociety⁩ for funding our research of the gut microbiome as a potential trigger of MS in the ⁦@MS_TWIN_STUDY⁩ 🥳🥳 nationalmssociety.org/About-…
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neuroimmunology-munich.de/ne…
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Germany’s second largest University Clinic sends S.O.S.- get vaccinated!!!
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Bcl6 controls meningeal Th17-B cell interaction in murine neuroinflammation pubmed.ncbi.nlm.nih.gov/3447…

Bcl6 controls meningeal Th17-B cell interaction in murine neuroinflammation - PubMed

Ectopic lymphoid tissue containing B cells forms in the meninges at late stages of human multiple sclerosis (MS) and when neuroinflammation is induced by interleukin (IL)-17 producing T helper (Th17)...

pubmed.ncbi.nlm.nih.gov
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Check out our new review: Microbiota and multiple sclerosis pubmed.ncbi.nlm.nih.gov/3304…

[Microbiota and multiple sclerosis] - PubMed

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system driven by autoreactive lymphocytes. Due to its close contact with the gut-associated lymphoid tissue, the intestinal...

pubmed.ncbi.nlm.nih.gov
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