B cells | Macrophages | Osteomorphs | #PrecisionImmunology | Cancer cell dormancy

Sydney, Australia
Thrilled to see mum & dad featured in Two of Us @GoodWeekendMag in @smh. Amazing interview & article by Fenella Souter. 🙏 58 years later... "I wouldn’t say we argue all the time...It’s just that my husband can take a long time to agree with me." 😅 smh.com.au/national/she-was-…
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How do, how do you do I've loved you since I first saw you Tell me will you be mine? Thru the winter and into summertime I can see the sun is poking through Shining on the likes of me and you I am going why dont you come too? Lets go where the sky is blue bsky.app/profile/labphan.bsk…
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My top 10 #ASH24 abstracts for plasma cell disorders/multiple myeloma #mmsm @ASH_hematology #mmsm 🧵
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An incredible #plasmacell undergoing #apoptosis seen at high resolution!🤩 #microscopymonday #EMmonday
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Only TWO DAYS LEFT to apply for this year's #ACDS Prize for Outstanding ECRs! 🏆 Awardees will receive a medal, $500 cash prize, and are invited to present an ACDS Seminar in 2025 🤩 Learn more and apply now at australasiancelldeathsociety…
📢 ICYMI: Applications for our 2024 ACDS Prize for Outstanding ECRs are NOW OPEN! 🏆 Awarded annually, this Prize recognises the stellar contributions of our ECRs to cell death research both locally & internationally 🤩 Must close 5pm AEST Friday 18 October - Apply now! ⏳
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Now out @ImmunityCP! Congrats @LMackayLab @maxevrard @ObersAndreas et al! First paper to use JaCa 'dirty mice' to diversify the microbiome, mature the immune system & promote Trm development in SPF mice. We made JaCa mice made @GarvanInstitute... cell.com/immunity/abstract/S…
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...to provide a stable source of diverse microbiome for horizontal transfer. JaCa has unmasked autoimmune phenotypes in mouse avatars of human disease eg TNFAIP3 haploinsufficiency. JaCa are community resource so pls reach out if you want to use them! biorxiv.org/content/10.1101/…
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Popper used to begin his lecture course on the philosophy of science by asking the students simply to ‘observe’. Then he would wait in silence for one of them to ask what they were supposed to observe. This was his way of demonstrating one of many flaws in the empiricism that is still part of common sense today. So he would explain to them that scientific observation is impossible without pre-existing knowledge about what to look at, what to look for, how to look, and how to interpret what one sees. And he would explain that, therefore, theory has to come first. It has to be conjectured, not derived. @DavidDeutschOxf
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I am happy to share a large part of my postdoctoral work published in @SciImmunology! Using LIPSTIC, we identify and characterize antigen-presenting dendritic cells (DCs) in the tumor-draining lymph node and tumor microenvironment science.org/doi/10.1126/scii…
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Multiple Sclerosis is entering its 2024 ERA – that means new treatments on the horizon and a new changes to the McDonald DIAGNOSTIC CRITERIA! Some of these changes are quite significant – to get everyone up to speed I made this thread!
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>15,000 km and >20h later made it to Toronto for my first in-person #ASBMR2024. Got my badge and ribbons 😊. All set to share all things #Intravital imaging #Bone. Please reach out if interested in chat the more peeps doing intravital the better!
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An amazing few days talking immunology and clinical translation. Thanks to everyone who was involved! Watch this space in the years ahead for the clinical impacts from the passionate student and ECR researchers who were there.
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Congrats Nicole, Thomas & Belinda this is a great reference to keep by your side!
This important review from the @parkerlabPMCC has been published in @NatRevImmunol highlighting multiple mechanisms cancers use to evade immune detection during metastatic spread & considerations to target aggressive cancers @Nicole160368 @thomasbchadwick go.nature.com/4gq0URQ
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Love it! Congrats Peter and Rob! Very happy to make a small contribution to this timely review on an emerging area of drug development. Splice up your life!
Splice up your life! Excited to share our new Review on the potential of thinking protein isoforms when it comes to therapeutics! Link: rdcu.be/dSXxy Written with @Neuro_RNA @LabPhan A short overview🧵

ALT Wannabe Spice Girls GIF

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Protein isoform-centric therapeutics: expanding targets and increasing specificity tinyurl.com/2v5c3us8 Many genes encode multiple protein isoforms. This new review discusses targeting isoforms as a route to drugs with greater specificity and fewer adverse effects
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Please check out this opportunity to work with amazing scientist @seyhanyazar unraveling GxE interactions in complex autoimmune diseases. Come work in exciting supportive cross-disciplinary environment in #PrecisionImmunology program @GarvanInstitute! Please share & retweet!
Pls RT! I am advertising for a postdoc to join my new team at @GarvanInstitute, where we are working to decipher autoimmune & allergic diseases using cutting-edge single-cell sequencing technologies. More information is available here: seek.com.au/Garvan-Institute…
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Phan Lab retweeted
Using concepts from multi-modal #Omics data integration, Extensible Immunofluorescence (ExIF; shorturl.at/d3N75) allows highly multiplexed single cell analyses of complex biology (here of #EMT) by integrating standard 4-plex #fluorescenceimaging data via virtual labelling.
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Cecelia: Quantitative multi-dimensional image analysis made easier! No jumping between several software packages. github.com/schienstockd/cece… doi.org/10.1101/2024.08.13.6…
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Exciting opportunity! @seyhanyazar is brilliant leader in disentangling GxE interactions in #PrecisionImmunology Program @GarvanInstitute & @UNSWMedicine using biomedical knowledge graphs to predict risk of Multiple Sclerosis (MS) via Electronic Health Record (EHR) retrieval.
PhD in AI & Health? Join us & our industry partner to use AI for an innovative Multiple Sclerosis (MS) project! Analyse health data, predict MS & improve treatment. Apply now! ➡️ unsw.edu.au/research/hdr/our… #phd #AI #health #MS #biomedical #datascience
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